P07947 | YES_HUMAN | Tyrosine-protein kinase Yes (YES1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 158~240 | |
| PF00018 | SH3_1 - SH3 domain | 97~144 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 278~526 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // SH3_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL400402 |  |
IC50 | = | 0.3 | nM | 475.98 | Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 | Homo sapiens | CHEMBL932927 | single protein format |
| CHEMBL5280844 |  |
IC50 | = | 0.39 | nM | 478.94 | O=C(c1ccc(Oc2ccccc2)cc1Cl)c1c[nH]c2ncnc(NC3CC[C@@H](CO)OC3)c12 | Homo sapiens | CHEMBL5242632 | single protein format |
| CHEMBL288441 |  |
IC50 | = | 0.4 | nM | 530.46 | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl | Homo sapiens | CHEMBL1244321 | single protein format |
| CHEMBL3824089 |  |
IC50 | < | 0.5 | nM | 510.64 | COc1cc(-c2nn(CCN3CCC(N(C)C)CC3)c3ncnc(N)c23)ccc1NC(=O)OC(C)(C)C | Homo sapiens | CHEMBL3824532 | single protein format |
| CHEMBL5416410 |  |
IC50 | = | 0.5 | nM | 506.03 | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O | Homo sapiens | CHEMBL912341 | single protein format |
| CHEMBL3651257 |  |
IC50 | = | 0.7 | nM | 475.98 | Cc1cc2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2cc1-c1cc(O)ccc1Cl | Homo sapiens | CHEMBL3707872 | single protein format |
| CHEMBL3647967 |  |
IC50 | = | 0.8 | nM | 454.53 | C=CC(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 | Homo sapiens | CHEMBL3887543 | single protein format |
| CHEMBL3426225 |  |
IC50 | = | 0.8 | nM | 576.63 | CCn1nc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)c2c(N)ncnc21 | Homo sapiens | CHEMBL3429869 | single protein format |
| CHEMBL1171837 |  |
IC50 | = | 0.89 | nM | 532.57 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | Homo sapiens | CHEMBL4721779 | single protein format |
| CHEMBL4798527 |  |
IC50 | = | 1.0 | nM | 548.57 | Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 | Homo sapiens | CHEMBL4766143 | single protein format |
| CHEMBL495727 |  |
IC50 | = | 1.0 | nM | 381.44 | O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 | Homo sapiens | CHEMBL1009922 | single protein format |
| CHEMBL436137 |  |
IC50 | = | 1.0 | nM | 453.59 | Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1 | Homo sapiens | CHEMBL908983 | single protein format |
| CHEMBL3651296 |  |
IC50 | = | 1.2 | nM | 452.6 | Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCC4CCCC4)cc3)nnc2c1 | Homo sapiens | CHEMBL3707872 | single protein format |
| CHEMBL3651228 |  |
IC50 | = | 1.24 | nM | 476.97 | Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3cccc(C(=O)NCCN(C)C)c3)nc12 | Homo sapiens | CHEMBL3707872 | single protein format |
| CHEMBL5268244 |  |
IC50 | = | 1.3 | nM | 579.61 | C#CCO[C@@H]1[C@H](C)[C@@H](COC(=O)c2ccc(S(=O)(=O)F)cc2)O[C@H]1n1nc(-c2ccc(C)cc2)c2c(N)ncnc21 | Homo sapiens | CHEMBL5243514 | single protein format |
| CHEMBL249821 |  |
IC50 | = | 1.3 | nM | 539.06 | Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc12 | Homo sapiens | CHEMBL932927 | single protein format |
| CHEMBL522892 |  |
IC50 | = | 1.4 | nM | 392.44 | CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 | Homo sapiens | CHEMBL2411892 | single protein format |
| CHEMBL1738757 |  |
IC50 | = | 1.5 | nM | 553.6 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1 | Homo sapiens | CHEMBL2411892 | single protein format |
| CHEMBL364623 |  |
IC50 | = | 2.0 | nM | 373.87 | Cc1cc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)nc(C)n1 | Homo sapiens | CHEMBL912341 | single protein format |
| CHEMBL2336005 |  |
IC50 | = | 2.1 | nM | 417.53 | Oc1cccc(Nc2ccnc3cc(-c4cccc(CN5CCOCC5)c4)sc23)c1 | Homo sapiens | CHEMBL3707680 | cell membrane format |