ProtHub

P07814 | SYEP_HUMAN | Bifunctional glutamate/proline--tRNA ligase (EPRS1)

Pfam Domain Table

Accession	Domain	Range	Color
PF00458	WHEP-TRS - WHEP-TRS domain	753~805
PF00458	WHEP-TRS - WHEP-TRS domain	826~878
PF00458	WHEP-TRS - WHEP-TRS domain	904~955
PF00587	tRNA-synt_2b - tRNA synthetase class II core domain (G, H, P, S and T)	1113~1284
PF00749	tRNA-synt_1c - tRNA synthetases class I (E and Q), catalytic domain	197~501
PF03129	HGTP_anticodon - Anticodon binding domain	1303~1403
PF03950	tRNA-synt_1c_C - tRNA synthetases class I (E and Q), anti-codon binding domain	504~594
PF09180	ProRS-C_1 - Prolyl-tRNA synthetase, C-terminal	1430~1512
PF20974	tRNA-synt_1c_C2 - tRNA synthetases class I (E and Q), anti-codon binding domain	606~681
PF21972	Arc1p_N_like - Nuclear-export cofactor Arc1p	92~155

3D structures mapped by conservation among orthologs

[ Domain: "S15/NS1 RNA-binding domain" // WHEP-TRS ]

1FYJ

[ Domain: "Glutathione S-transferase (GST)-C" // GST_C_3 ]

[ Domain: "C-terminal domain of ProRS" // ProRS-C_1 ]

[ Domain: "Class II aaRS and biotin synthetases" // tRNA-synt_2b ]

[ Domain: "Anticodon-binding domain of Class II aaRS" // HGTP_anticodon ]

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

Only the first 20 rows are shown.

molecule_chembl_id	structure	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL1163086		Ki	=	0.6	nM	443.44	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COS(=O)(=O)NC(=O)[C@@H]2CCCN2)[C@@H](O)[C@H]1O	Homo sapiens	CHEMBL5257976	single protein format
CHEMBL357355		Ki	=	15.0	nM	376.64	Cc1cc(Cl)cc2c(C(=O)O)cc(-c3ccc(Br)cc3)nc12	Homo sapiens	CHEMBL844882	single protein format
CHEMBL5279127		Ki	=	85.0	nM	443.44	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COS(=O)(=O)NC(=O)[C@H]2CCCN2)[C@@H](O)[C@H]1O	Homo sapiens	CHEMBL5257976	single protein format