P07384 | CAN1_HUMAN | Calpain-1 catalytic subunit (CAPN1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00648 | Peptidase_C2 - Calpain family cysteine protease | 56~352 | |
| PF01067 | Calpain_III - Calpain large subunit, domain III | 371~514 | |
| PF13833 | EF-hand_8 - EF-hand domain pair | 557~616 |
3D structures mapped by conservation among orthologs
[ Domain: "Cysteine proteinases" // Peptidase_C2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL151521 |  |
IC50 | = | 4.0 | nM | 362.47 | CC(C)C[C@@H](C=O)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)(C)C | Homo sapiens | CHEMBL656195 | single protein format |
| CHEMBL150600 |  |
IC50 | = | 4.0 | nM | 348.44 | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)C(C)C | Homo sapiens | CHEMBL656195 | single protein format |
| CHEMBL357595 |  |
IC50 | = | 5.0 | nM | 433.55 | CC(C)C[C@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1 | Homo sapiens | CHEMBL656195 | single protein format |
| CHEMBL8378 |  |
IC50 | = | 5.0 | nM | 420.92 | CCN1C(C(=O)N[C@H](C=O)Cc2ccccc2)Cc2cc(Cl)ccc2S1(=O)=O | Homo sapiens | CHEMBL654078 | single protein format |
| CHEMBL299750 |  |
IC50 | = | 6.0 | nM | 545.64 | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NOCc1ccccc1 | Homo sapiens | CHEMBL657770 | single protein format |
| CHEMBL326161 |  |
IC50 | = | 6.0 | nM | 428.47 | CN1C(C(=O)N[C@H](C=O)Cc2ccccc2)=Cc2cc3c(cc2S1(=O)=O)OCCO3 | Homo sapiens | CHEMBL877099 | single protein format |
| CHEMBL345338 |  |
IC50 | = | 6.0 | nM | 546.71 | CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1 | Homo sapiens | CHEMBL656195 | single protein format |
| CHEMBL423222 |  |
IC50 | = | 7.0 | nM | 502.61 | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccc(OCc2ccccc2)cc1 | Homo sapiens | CHEMBL656195 | single protein format |
| CHEMBL118688 |  |
IC50 | = | 7.0 | nM | 441.34 | CN1C(C(=O)N[C@H](C=O)Cc2ccccc2)Cc2cc(Cl)c(Cl)cc2S1(=O)=O | Homo sapiens | CHEMBL877099 | single protein format |
| CHEMBL8605 |  |
IC50 | = | 7.0 | nM | 358.42 | O=C[C@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2S(=O)(=O)N1 | Homo sapiens | CHEMBL654079 | single protein format |
| CHEMBL127231 |  |
IC50 | = | 7.0 | nM | 378.47 | CC(C)CC(NC(=O)OCc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)O | Homo sapiens | CHEMBL658527 | single protein format |
| CHEMBL168471 |  |
IC50 | = | 7.5 | nM | 372.46 | CC(C)C[C@H](C=O)NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C | Homo sapiens | CHEMBL744609 | single protein format |
| CHEMBL347742 |  |
IC50 | = | 8.0 | nM | 407.47 | CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccc([N+](=O)[O-])cc1 | Homo sapiens | CHEMBL656195 | single protein format |
| CHEMBL356841 |  |
IC50 | = | 8.0 | nM | 362.47 | CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 | Homo sapiens | CHEMBL656195 | single protein format |
| CHEMBL269333 |  |
IC50 | = | 8.0 | nM | 442.49 | CCN1C(C(=O)N[C@H](C=O)Cc2ccccc2)=Cc2cc3c(cc2S1(=O)=O)OCCO3 | Homo sapiens | CHEMBL877099 | single protein format |
| CHEMBL345337 |  |
IC50 | = | 8.0 | nM | 525.65 | CC(C)C[C@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1 | Homo sapiens | CHEMBL656195 | single protein format |
| CHEMBL2371036 |  |
IC50 | = | 10.0 | nM | 334.42 | CC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 | Homo sapiens | CHEMBL656195 | single protein format |
| CHEMBL168909 |  |
IC50 | = | 10.0 | nM | 404.53 | CC(C)C[C@H](C=O)NC(=O)[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)C(C)C | Homo sapiens | CHEMBL744609 | single protein format |
| CHEMBL341014 |  |
IC50 | = | 10.0 | nM | 396.49 | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 | Homo sapiens | CHEMBL656195 | single protein format |
| CHEMBL89668 |  |
IC50 | = | 10.0 | nM | 469.54 | CONC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 | Homo sapiens | CHEMBL657770 | single protein format |