P07333 | CSF1R_HUMAN | Macrophage colony-stimulating factor 1 receptor (CSF1R)

Pfam Domain Table

AccessionDomainRangeColor
PF00047ig - Immunoglobulin domain212~291
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase582~910
PF25305Ig_PDGFR_d4 - Platelet-derived growth factor receptor Ig-like domain 4414~531

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_4 ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_5 ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // IG_like ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_13 ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_2 ]

 PyMOL session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5415149 IC50 = 0.2 nM 367.45 CN(CC1CCOCC1)c1ncnc2[nH]c(-c3ccc(CCO)cc3)nc12 Homo sapiens CHEMBL5323092 single protein format
CHEMBL5418087 IC50 < 0.3 nM 400.48 Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(CCC(=O)O)cc4)cc23)c1 Homo sapiens CHEMBL5342462 single protein format
CHEMBL5404686 IC50 = 0.3 nM 353.43 CN(CC1CCOCC1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 Homo sapiens CHEMBL5323092 single protein format
CHEMBL1171604 IC50 = 0.3 nM 446.56 CN1CC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCC(C)(C)CC3)c2)CN(C)C1=O Homo sapiens CHEMBL1174608 single protein format
CHEMBL5434318 IC50 = 0.3 nM 362.41 CN(Cc1ccccc1F)c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12 Homo sapiens CHEMBL5342458 single protein format
CHEMBL5432649 IC50 = 0.3 nM 360.42 CN(Cc1ccccc1O)c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12 Homo sapiens CHEMBL5342458 single protein format
CHEMBL2023485 IC50 < 0.3 nM 462.51 CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)n[nH]1 Homo sapiens CHEMBL2027407 single protein format
CHEMBL5439126 IC50 = 0.3 nM 372.43 Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(C(=O)O)cc4)cc23)c1 Homo sapiens CHEMBL5342462 single protein format
CHEMBL5398686 IC50 < 0.3 nM 347.44 [2H]C([2H])([2H])N(Cc1ccccc1)c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12 Homo sapiens CHEMBL5342458 single protein format
CHEMBL438533 IC50 = 0.3 nM 392.5 CC1CCN(c2cc(C3CCNCC3)ccc2NC(=O)c2ccc(C#N)o2)CC1 Homo sapiens CHEMBL933669 single protein format
CHEMBL489684 IC50 = 0.3 nM 512.61 CCc1ccc(-n2cc(C(=O)NOC)c(=O)c3cnc(Nc4ccc(C5CCN(C)CC5)cc4)nc32)cc1 Homo sapiens CHEMBL961253 single protein format
CHEMBL521580 IC50 = 0.4 nM 518.66 CONC(=O)c1cn(C2CCC(C)(C)CC2)c2nc(Nc3ccc(C4CCN(C)CC4)cc3)ncc2c1=O Homo sapiens CHEMBL961253 single protein format
CHEMBL402337 IC50 = 0.4 nM 389.5 CC1CC=C(c2cc(C3CCNCC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 Homo sapiens CHEMBL933669 single protein format
CHEMBL3349454 IC50 = 0.4 nM 470.58 CN1CC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCC(C)(C)CC3)c2)CN(C)C1=NC#N Homo sapiens CHEMBL1174608 single protein format
CHEMBL5417607 IC50 = 0.4 nM 432.55 CN(C)CCNCc1ccc(-c2cc3c(N(C)Cc4ccccc4)ncnc3[nH]2)cc1F Homo sapiens CHEMBL5342458 single protein format
CHEMBL489881 IC50 = 0.4 nM 512.61 CCc1cccc(-n2cc(C(=O)NOC)c(=O)c3cnc(Nc4ccc(C5CCN(C)CC5)cc4)nc32)c1 Homo sapiens CHEMBL961253 single protein format
CHEMBL5425883 IC50 = 0.4 nM 490.6 COCCOCCOCCOc1ccc(-c2cc3c(N(C)Cc4cccc(C)c4)ncnc3[nH]2)cc1 Homo sapiens CHEMBL5342462 single protein format
CHEMBL492809 IC50 = 0.4 nM 524.63 CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(C4CCN(C)CC4)cc3)ncc2c1=O Homo sapiens CHEMBL961253 single protein format
CHEMBL5405206 IC50 = 0.4 nM 390.42 Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(C(=O)O)c(F)c4)cc23)c1 Homo sapiens CHEMBL5342462 single protein format
CHEMBL5430348 IC50 = 0.4 nM 428.54 Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(CCCCC(=O)O)cc4)cc23)c1 Homo sapiens CHEMBL5342462 single protein format