P07332 | FES_HUMAN | Tyrosine-protein kinase Fes/Fps (FES)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 460~529 | |
| PF00611 | FCH - Fes/CIP4, and EFC/F-BAR homology domain | 12~85 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 562~814 |
3D structures mapped by conservation among orthologs
[ Domain: "BAR/IMD domain-like" // FCH ]
[ Domain: "SH2" // SH2 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL459850 |  |
IC50 | = | 1.0 | nM | 456.43 | Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(N)nc2N(C)C1=O | Homo sapiens | CHEMBL974016 | single protein format |
| CHEMBL4846921 |  |
IC50 | = | 4.9 | nM | 508.67 | CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(NS(C)(=O)=O)c5)c4n3)cc2)CC1 | Homo sapiens | CHEMBL4839030 | single protein format |
| CHEMBL3128069 |  |
IC50 | = | 5.0 | nM | 470.53 | Cc1nc([C@](C)(O)CO)sc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 | Homo sapiens | CHEMBL3129258 | single protein format |
| CHEMBL3286830 |  |
IC50 | = | 6.0 | nM | 406.42 | C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 | Homo sapiens | CHEMBL3293404 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 8.1 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3820487 | single protein format |
| CHEMBL2064666 |  |
IC50 | = | 99.0 | nM | 539.08 | COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CC[C@@H](N1CCOCC1)CC2 | Homo sapiens | CHEMBL2067591 | single protein format |
| CHEMBL5088153 |  |
IC50 | = | 269.0 | nM | 575.07 | Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(Cl)cc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 | Homo sapiens | CHEMBL5045159 | single protein format |
| CHEMBL288441 |  |
IC50 | = | 358.0 | nM | 530.46 | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl | Homo sapiens | CHEMBL1244585 | single protein format |
| CHEMBL4474361 |  |
IC50 | = | 494.0 | nM | 537.65 | COc1cc(N2CCC(O)CC2)ccc1Nc1nc(Nc2ccccc2S(=O)(=O)C(C)C)c2cn[nH]c2n1 | Homo sapiens | CHEMBL4360630 | single protein format |
| CHEMBL4125960 |  |
IC50 | = | 527.0 | nM | 537.59 | CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(Oc4ccnc5[nH]ccc45)c3)cc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL4360630 | single protein format |
| CHEMBL460472 |  |
IC50 | = | 706.0 | nM | 539.59 | COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 | Homo sapiens | CHEMBL985572 | single protein format |
| CHEMBL386637 |  |
IC50 | = | 910.0 | nM | 526.54 | CN(C)[C@H]1CCCN(c2ccc(C(F)(F)F)cc2NC(=O)c2cc(C#Cc3cnc(N)nc3)ccc2F)C1 | Homo sapiens | CHEMBL910180 | single protein format |
| CHEMBL3286830 | |
Ki | = | 6.0 | nM | 406.42 | C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 | Homo sapiens | CHEMBL5213171 | single protein format |