P07237 | PDIA1_HUMAN | Protein disulfide-isomerase (P4HB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00085 | Thioredoxin - Thioredoxin | 26~131 | |
| PF00085 | Thioredoxin - Thioredoxin | 369~471 | |
| PF13848 | Thioredoxin_6 - Thioredoxin-like domain | 161~344 |
3D structures mapped by conservation among orthologs
[ Domain: "Thioredoxin-like" // Thioredoxin ]
[ Domain: "Thioredoxin-like" // Thioredoxin_6_N ]
[ Domain: "Thioredoxin-like" // Thioredoxin_6_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4748449 |  |
IC50 | = | 23.0 | nM | 341.36 | Oc1cc2c(cc1C(c1ccc3c(c1)OCO3)N1CCCC1)OCO2 | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL4786482 |  |
IC50 | = | 72.0 | nM | 364.36 | Oc1cc2c(cc1C(Nc1ccccn1)c1ccc3c(c1)OCO3)OCO2 | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL1369923 |  |
IC50 | = | 92.0 | nM | 347.8 | Oc1cc2c(cc1C(c1ccc(Cl)cc1)N1CCOCC1)OCO2 | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL3741464 |  |
IC50 | = | 110.0 | nM | 326.4 | Oc1c(C(Nc2ccccc2)c2ccccc2)ccc2cccnc12 | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL4483086 |  |
IC50 | = | 120.0 | nM | 282.3 | COC(=O)c1cccc(/C=C/C(=O)c2cccc(O)c2)c1 | Homo sapiens | CHEMBL4390738 | assay format |
| CHEMBL1319324 |  |
IC50 | = | 130.0 | nM | 343.38 | COc1ccc(C(c2cc3c(cc2O)OCO3)N2CCOCC2)cc1 | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL4472710 |  |
IC50 | = | 130.0 | nM | 375.22 | COC(=O)c1cccc(/C=C/C(=O)c2ccc(CO)c(Br)c2)c1 | Homo sapiens | CHEMBL4390738 | assay format |
| CHEMBL4740031 |  |
IC50 | = | 140.0 | nM | 359.4 | Cc1ccnc(NC(c2ccc(F)cc2)c2ccc3cccnc3c2O)c1 | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL3703646 |  |
IC50 | = | 150.0 | nM | 387.44 | COc1ccc(C(Nc2cc(C)ccn2)c2ccc3cccnc3c2O)cc1O | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL1688556 |  |
IC50 | = | 150.0 | nM | 371.4 | O=[N+]([O-])c1ccc(NC(c2ccccc2)c2ccc3cccnc3c2O)cc1 | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL4459949 |  |
IC50 | = | 160.0 | nM | 452.62 | CCCCCN(CCCCC)S(=O)(=O)c1ccc(C(=O)/C=C/c2cccc(C#N)c2)cc1 | Homo sapiens | CHEMBL4390738 | assay format |
| CHEMBL590899 |  |
IC50 | = | 170.0 | nM | 361.83 | Oc1c(C(Nc2ccccn2)c2ccc(Cl)cc2)ccc2cccnc12 | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL4780610 |  |
IC50 | = | 170.0 | nM | 396.4 | COc1cc(C(Nc2ccccn2)c2cc3c(cc2O)OCO3)cc(OC)c1O | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL591855 |  |
IC50 | = | 170.0 | nM | 355.44 | CCc1ccc(C(Nc2ccccn2)c2ccc3cccnc3c2O)cc1 | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL4790355 |  |
IC50 | = | 180.0 | nM | 417.47 | COc1cc(C(Nc2ccc(C)cn2)c2ccc3cccnc3c2O)cc(OC)c1O | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL1557864 |  |
IC50 | = | 180.0 | nM | 387.43 | COc1cc(C(c2cc3c(cc2O)OCO3)N2CCCC2)cc(OC)c1OC | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL600752 |  |
IC50 | = | 190.0 | nM | 369.47 | Cc1cc(C)c(C(Nc2ccccn2)c2ccc3cccnc3c2O)c(C)c1 | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL1536119 |  |
IC50 | = | 190.0 | nM | 417.93 | CCOC(=O)C1(CCOc2ccccc2)CCN(Cc2ccc(O)c(Cl)c2)CC1 | Homo sapiens | CHEMBL4257297 | assay format |
| CHEMBL4753606 |  |
IC50 | < | 200.0 | nM | 308.38 | Oc1c(C(c2ccncc2)N2CCCCC2)ccc2ccoc12 | Homo sapiens | CHEMBL4729810 | assay format |
| CHEMBL4776896 |  |
IC50 | < | 200.0 | nM | 387.38 | Oc1c(C(c2ccc3c(c2)OC(F)(F)O3)N2CCCCC2)ccc2ccoc12 | Homo sapiens | CHEMBL4729810 | assay format |