P07202 | PERT_HUMAN | Thyroid peroxidase (TPO)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00084 | Sushi - Sushi repeat (SCR repeat) | 742~794 | |
| PF03098 | An_peroxidase - Animal haem peroxidase | 151~709 | |
| PF07645 | EGF_CA - Calcium-binding EGF domain | 796~838 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5200638 |  |
IC50 | = | 590.0 | nM | 276.3 | O=c1[nH]c(=S)n(Cc2ccc(F)cc2)c2nc[nH]c12 | Homo sapiens | CHEMBL5130502 | cell-based format |
| CHEMBL4859908 |  |
IC50 | = | 640.0 | nM | 291.32 | Nc1cc(Cc2ccn(-c3ccccc3)n2)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4812317 | cell-based format |
| CHEMBL4869433 |  |
IC50 | = | 700.0 | nM | 309.31 | Nc1cc(Cc2ccn(-c3ccc(F)cc3)n2)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4812317 | cell-based format |
| CHEMBL4855931 |  |
IC50 | = | 710.0 | nM | 367.42 | Nc1cc(Cc2ccn(-c3cccc(-c4ccccc4)c3)n2)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4812317 | cell-based format |
| CHEMBL5181350 |  |
IC50 | = | 770.0 | nM | 335.82 | C[C@@H](N)c1cc(Cl)ccc1Cn1c(=S)[nH]c(=O)c2[nH]cnc21 | Homo sapiens | CHEMBL5130502 | cell-based format |
| CHEMBL5095218 |  |
IC50 | = | 890.0 | nM | 334.83 | C[C@@H](N)c1cc(Cl)ccc1Cn1c(=S)[nH]c(=O)c2[nH]ccc21 | Homo sapiens | CHEMBL5130502 | cell-based format |
| CHEMBL3633460 |  |
IC50 | = | 990.0 | nM | 325.78 | COc1ccc(Cl)cc1-c1cc(=O)[nH]c(=S)n1CC(N)=O | Homo sapiens | CHEMBL5130502 | cell-based format |