P07195 | LDHB_HUMAN | L-lactate dehydrogenase B chain (LDHB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00056 | Ldh_1_N - lactate/malate dehydrogenase, NAD binding domain | 23~161 | |
| PF02866 | Ldh_1_C - lactate/malate dehydrogenase, alpha/beta C-terminal domain | 165~330 |
3D structures mapped by conservation among orthologs
[ Domain: "LDH C-terminal domain-like" // Ldh_1_C_13 ]
[ Domain: "NAD(P)-binding Rossmann-fold domains" // Ldh_1_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4059985 |  |
IC50 | = | 8.0 | nM | 494.6 | NS(=O)(=O)c1ccc(Cc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2CC2CC2)cc1 | Homo sapiens | CHEMBL4032332 | assay format |
| CHEMBL5172378 |  |
IC50 | = | 8.9 | nM | 429.95 | Nc1cccc(C2(c3ccsc3)CC(O)=C(Sc3ccccc3Cl)C(=O)O2)c1 | Homo sapiens | CHEMBL5138279 | single protein format |
| CHEMBL5181996 |  |
IC50 | = | 15.0 | nM | 430.93 | O=C1OC(c2ccsc2)(c2ccccc2O)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL5138279 | single protein format |
| CHEMBL5182266 |  |
IC50 | = | 17.0 | nM | 525.03 | O=C1OC(c2ccsc2)(c2cccc(Nc3ccc(F)cc3)n2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL5138279 | single protein format |
| CHEMBL4100845 |  |
IC50 | = | 20.0 | nM | 556.67 | NS(=O)(=O)c1ccc(Cc2c(-c3cccc(-c4ccccc4)c3)nn(-c3nc(C(=O)O)cs3)c2C2CC2)cc1 | Homo sapiens | CHEMBL4032332 | assay format |
| CHEMBL4090677 |  |
IC50 | = | 20.0 | nM | 480.57 | NS(=O)(=O)c1ccc(Cc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2C2CC2)cc1 | Homo sapiens | CHEMBL4032332 | assay format |
| CHEMBL4081890 |  |
IC50 | = | 27.0 | nM | 570.7 | NS(=O)(=O)c1ccc(Cc2c(-c3cccc(-c4ccccc4)c3)nn(-c3nc(C(=O)O)cs3)c2CC2CC2)cc1 | Homo sapiens | CHEMBL4032332 | assay format |
| CHEMBL4436150 |  |
IC50 | = | 30.0 | nM | 499.06 | O=C1NC(c2ccc(N3CCOCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL4431229 | single protein format |
| CHEMBL5202219 |  |
IC50 | = | 34.0 | nM | 542.03 | O=C1NC(c2ccsc2)(c2cccc(Nc3ccc(F)c(F)c3)n2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL5138279 | single protein format |
| CHEMBL4467769 |  |
IC50 | = | 35.0 | nM | 540.11 | CC(=O)N1CCN(c2ccc(C3(c4ccsc4)CC(O)=C(Sc4ccccc4Cl)C(=O)N3)cc2)CC1 | Homo sapiens | CHEMBL4431229 | single protein format |
| CHEMBL4576717 |  |
IC50 | = | 35.0 | nM | 523.05 | O=C1NC(c2ccsc2)(c2cccc(Nc3ccc(F)cc3)c2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL4431229 | single protein format |
| CHEMBL4536094 |  |
IC50 | = | 46.0 | nM | 547.12 | O=C1NC(c2ccc(N3CCS(=O)(=O)CC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL4431229 | single protein format |
| CHEMBL5177632 |  |
IC50 | = | 47.0 | nM | 524.04 | O=C1O[C@@](c2ccsc2)(c2cccc(Nc3ccc(F)cc3)c2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL5138279 | single protein format |
| CHEMBL4080497 |  |
IC50 | = | 49.0 | nM | 516.6 | NS(=O)(=O)c1ccc(Cc2cn(-c3nc(C(=O)O)cs3)nc2-c2cccc(-c3ccccc3)c2)cc1 | Homo sapiens | CHEMBL4032332 | assay format |
| CHEMBL4520899 |  |
IC50 | = | 49.0 | nM | 497.09 | O=C1NC(c2ccc(N3CCCCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL4431229 | single protein format |
| CHEMBL4444963 |  |
IC50 | = | 50.0 | nM | 483.06 | O=C1NC(c2ccc(N3CCCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL4431229 | single protein format |
| CHEMBL4453059 |  |
IC50 | = | 55.0 | nM | 457.02 | CN(C)c1ccc(C2(c3ccsc3)CC(O)=C(Sc3ccccc3Cl)C(=O)N2)cc1 | Homo sapiens | CHEMBL4431229 | single protein format |
| CHEMBL4521960 |  |
IC50 | = | 57.0 | nM | 429.95 | O=C1NC(c2ccc(O)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL4431229 | single protein format |
| CHEMBL4475593 |  |
IC50 | = | 60.0 | nM | 522.1 | N#CC1CCN(c2ccc(C3(c4ccsc4)CC(O)=C(Sc4ccccc4Cl)C(=O)N3)cc2)CC1 | Homo sapiens | CHEMBL4431229 | single protein format |
| CHEMBL4101800 |  |
IC50 | = | 62.0 | nM | 584.6 | NS(=O)(=O)c1ccc(Cc2c(-c3cccc(-c4ccccc4)c3)nn(-c3nc(C(=O)O)cs3)c2C(F)(F)F)cc1 | Homo sapiens | CHEMBL4032332 | assay format |