P07099 | HYEP_HUMAN | Epoxide hydrolase 1 (EPHX1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00561 | Abhydrolase_1 - alpha/beta hydrolase fold | 142~403 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3642246 |  |
IC50 | = | 0.4 | nM | 511.44 | O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL1257759 |  |
IC50 | = | 0.4 | nM | 457.47 | Cc1ccc(S(=O)(=O)N2CCC(NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL1257517 |  |
IC50 | = | 0.4 | nM | 399.29 | O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C(F)(F)F)CC1 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL1257880 |  |
IC50 | = | 0.8 | nM | 536.58 | CN(C)c1cccc2c(S(=O)(=O)N3CCC(NC(=O)Nc4ccc(OC(F)(F)F)cc4)CC3)cccc12 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL3642245 |  |
IC50 | = | 0.9 | nM | 335.45 | COC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL217758 |  |
IC50 | = | 1.1 | nM | 373.42 | O=C(NC1CCN(C(=O)C(F)(F)F)CC1)NC12CC3CC(CC(C3)C1)C2 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL215121 |  |
IC50 | = | 1.1 | nM | 453.58 | COC(=O)c1cccc(C(=O)N2CCC(CNC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c1 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL215999 |  |
IC50 | = | 1.1 | nM | 439.56 | COC(=O)c1ccc(C(=O)N2CCC(NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL215908 |  |
IC50 | = | 1.1 | nM | 453.58 | COC(=O)c1ccc(C(=O)N2CCC(CNC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL215161 |  |
IC50 | = | 1.2 | nM | 382.51 | O=C(NC1CCN(C(=O)c2ccccn2)CC1)NC12CC3CC(CC(C3)C1)C2 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL216016 |  |
IC50 | = | 1.3 | nM | 381.52 | O=C(NC1CCN(C(=O)c2ccccc2)CC1)NC12CC3CC(CC(C3)C1)C2 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL1668935 |  |
IC50 | = | 1.4 | nM | 355.5 | CS(=O)(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL214644 |  |
IC50 | = | 1.7 | nM | 439.56 | COC(=O)c1ccccc1C(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL214179 |  |
IC50 | = | 1.7 | nM | 382.51 | O=C(NC1CCN(C(=O)c2ccncc2)CC1)NC12CC3CC(CC(C3)C1)C2 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL384280 |  |
IC50 | = | 1.8 | nM | 453.58 | COC(=O)c1ccccc1C(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL214127 |  |
IC50 | = | 1.8 | nM | 387.45 | O=C(NCC1CCN(C(=O)C(F)(F)F)CC1)NC12CC3CC(CC(C3)C1)C2 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL214128 |  |
IC50 | = | 2.1 | nM | 382.51 | O=C(NC1CCN(C(=O)c2cccnc2)CC1)NC12CC3CC(CC(C3)C1)C2 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL4741234 |  |
IC50 | = | 2.2 | nM | 385.37 | NC(=O)C(SCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCCC1 | Homo sapiens | CHEMBL4686507 | single protein format |
| CHEMBL215125 |  |
IC50 | = | 2.64 | nM | 347.5 | CCCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 | Homo sapiens | CHEMBL3705305 | single protein format |
| CHEMBL214505 |  |
IC50 | = | 2.7 | nM | 405.54 | COC(=O)CCCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 | Homo sapiens | CHEMBL3705305 | single protein format |