P06756 | ITAV_HUMAN | Integrin alpha-V (ITGAV)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00357 | Integrin_alpha - Integrin alpha cytoplasmic region | 1017~1031 | |
| PF01839 | FG-GAP - FG-GAP repeat | 253~286 | |
| PF01839 | FG-GAP - FG-GAP repeat | 306~347 | |
| PF01839 | FG-GAP - FG-GAP repeat | 370~406 | |
| PF08441 | Integrin_A_Ig_1 - Integrin alpha Ig-like domain 1 | 467~625 | |
| PF20805 | Integrin_A_Ig_2 - Integrin alpha Ig-like domain 2 | 626~764 | |
| PF20806 | Integrin_A_Ig_3 - Integrin alpha Ig-like domain 3 | 772~983 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // Integrin_alpha2_2nd ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // Integrin_alpha2_1st ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // Integrin_alpha2_3rd ]
[ Domain: "7-bladed" // FG-GAP_1st ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL474902 |  |
IC50 | = | 5.0 | nM | 483.53 | O=C(O)CC(c1cccnc1)N1CCc2cc(Oc3cccc4c3nc3n4CCCN3)ccc2C1=O | Homo sapiens | CHEMBL1029872 | single protein format |
| CHEMBL550802 |  |
IC50 | = | 8.0 | nM | 423.3 | O=C(NC[C@@H](NS(=O)(=O)c1ccc(Cl)cc1Cl)C(=O)O)c1ccsc1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL558130 |  |
IC50 | = | 11.0 | nM | 394.45 | Cc1cc(C)c(S(=O)(=O)N[C@H](CNC(=O)c2ccnn2C)C(=O)O)c(C)c1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL471675 |  |
IC50 | = | 14.0 | nM | 526.55 | O=C(O)CC(c1ccc2c(c1)OCO2)N1CCc2cc(Oc3cccc4c3nc3n4CCCN3)ccc2C1=O | Homo sapiens | CHEMBL1029872 | single protein format |
| CHEMBL558917 |  |
IC50 | = | 19.0 | nM | 423.3 | O=C(NC[C@@H](NS(=O)(=O)c1cccc(Cl)c1Cl)C(=O)O)c1ccsc1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL562067 |  |
IC50 | = | 24.0 | nM | 457.74 | O=C(NC[C@@H](NS(=O)(=O)c1c(Cl)cc(Cl)cc1Cl)C(=O)O)c1ccsc1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL559542 |  |
IC50 | = | 25.0 | nM | 474.28 | O=C(NC[C@@H](NS(=O)(=O)c1ccccc1I)C(=O)O)c1ccccc1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL560272 |  |
IC50 | = | 32.0 | nM | 380.42 | Cc1cc(C)c(S(=O)(=O)N[C@H](CNC(=O)c2ccoc2)C(=O)O)c(C)c1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL554267 |  |
IC50 | = | 41.0 | nM | 395.44 | Cc1cc(C)c(S(=O)(=O)N[C@H](CNC(=O)c2coc(C)n2)C(=O)O)c(C)c1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL559135 |  |
IC50 | = | 44.0 | nM | 396.49 | Cc1cc(C)c(S(=O)(=O)N[C@H](CNC(=O)c2ccsc2)C(=O)O)c(C)c1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL550522 |  |
IC50 | = | 62.0 | nM | 417.27 | O=C(NC[C@@H](NS(=O)(=O)c1cccc(Cl)c1Cl)C(=O)O)c1ccccc1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL558131 |  |
IC50 | = | 63.0 | nM | 392.44 | Cc1cc(C)c(S(=O)(=O)N[C@H](CNC(=O)c2cncnc2)C(=O)O)c(C)c1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL560928 |  |
IC50 | = | 78.0 | nM | 420.49 | COc1ccccc1C(=O)NC[C@@H](NS(=O)(=O)c1c(C)cc(C)cc1C)C(=O)O | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL562529 |  |
IC50 | = | 81.0 | nM | 391.45 | Cc1cc(C)c(S(=O)(=O)N[C@H](CNC(=O)c2cccnc2)C(=O)O)c(C)c1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL540432 |  |
IC50 | = | 98.0 | nM | 363.35 | N#Cc1cccc(S(=O)(=O)N[C@H](CNC(=O)c2ccoc2)C(=O)O)c1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL559740 |  |
IC50 | = | 118.0 | nM | 417.27 | O=C(NC[C@@H](NS(=O)(=O)c1c(Cl)cccc1Cl)C(=O)O)c1ccccc1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL561737 |  |
IC50 | = | 120.0 | nM | 390.46 | Cc1cc(C)c(S(=O)(=O)N[C@H](CNC(=O)c2ccccc2)C(=O)O)c(C)c1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL558939 |  |
IC50 | = | 208.0 | nM | 368.37 | COc1cccc(S(=O)(=O)N[C@H](CNC(=O)c2ccoc2)C(=O)O)c1 | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL561126 |  |
IC50 | = | 260.0 | nM | 352.37 | Cc1ccccc1S(=O)(=O)N[C@H](CNC(=O)c1ccoc1)C(=O)O | Homo sapiens | CHEMBL1053400 | single protein format |
| CHEMBL560670 |  |
IC50 | = | 260.0 | nM | 382.83 | O=C(NC[C@@H](NS(=O)(=O)c1ccccc1Cl)C(=O)O)c1ccccc1 | Homo sapiens | CHEMBL1053400 | single protein format |