ProtHub

P06746 | DPOLB_HUMAN | DNA polymerase beta (POLB)

Pfam Domain Table

Accession	Domain	Range	Color
PF10391	DNA_pol_lambd_f - Fingers domain of DNA polymerase lambda	100~147
PF14716	HHH_8 - Helix-hairpin-helix domain	12~82
PF14791	DNA_pol_B_thumb - DNA polymerase beta thumb	269~333
PF14792	DNA_pol_B_palm - DNA polymerase beta palm	149~262

3D structures mapped by conservation among orthologs

[ Domain: "SAM domain-like" // DNA_pol_lambd_f ]

[ Domain: "SAM domain-like" // HHH_8 ]

[ Domain: "Nucleotidyltransferase" // DNA_pol_B_palm ]

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV Ki CSV

Only the first 20 rows are shown.

molecule_chembl_id	structure	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL483492		IC50	=	1000.0	nM	483.18	Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)nc1N	Homo sapiens	CHEMBL658099	single protein format
CHEMBL2092835		IC50	=	1000.0	nM	469.15	Nc1ccn([C@@H]2C[C@@H](F)[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)n1	Homo sapiens	CHEMBL658099	single protein format
CHEMBL366356		Ki	=	390.0	nM	322.23	O=C(O)c1cc(O)c(O)c(OC(=O)c2cc(O)c(O)c(O)c2)c1	Homo sapiens	CHEMBL1018085	cell-based format
CHEMBL1162299		Ki	=	600.0	nM	480.2	Cc1cn([C@H]2C[C@H](O)[C@@H](COP(=O)(O)CP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O	Homo sapiens	CHEMBL1024687	single protein format
CHEMBL1162298		Ki	=	900.0	nM	465.19	Nc1ccn([C@H]2C[C@H](O)[C@@H](COP(=O)(O)CP(=O)(O)OP(=O)(O)O)O2)c(=O)n1	Homo sapiens	CHEMBL1024687	single protein format
CHEMBL1162300		Ki	=	1000.0	nM	505.21	Nc1nc2c(ncn2[C@H]2C[C@H](O)[C@@H](COP(=O)(O)CP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]1	Homo sapiens	CHEMBL1024687	single protein format