P06737 | PYGL_HUMAN | Glycogen phosphorylase, liver form (PYGL)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00343 | Phosphorylase - Carbohydrate phosphorylase | 114~828 |
3D structures mapped by conservation among orthologs
[ Domain: "UDP-Glycosyltransferase/glycogen phosphorylase" // Phosphorylase_C ]
[ Domain: "UDP-Glycosyltransferase/glycogen phosphorylase" // Phosphorylase_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL133911 |  |
IC50 | = | 1.0 | nM | 441.33 | O=C(Nc1c(F)cccc1Oc1ccc(C(=O)O)c(C(=O)O)c1)c1cc([N+](=O)[O-])ccn1 | Homo sapiens | CHEMBL680561 | assay format |
| CHEMBL134802 |  |
IC50 | = | 1.0 | nM | 473.4 | O=C(Nc1cc2ccccc2cc1Oc1ccc(C(=O)O)c(C(=O)O)c1)c1cc([N+](=O)[O-])ccn1 | Homo sapiens | CHEMBL680561 | assay format |
| CHEMBL115651 |  |
IC50 | = | 2.0 | nM | 504.37 | CC1=C(C(=O)OC(C)C)C(c2ccccc2Cl)C(C(=O)O)=C(C(=O)O)N1Cc1ccc(Cl)cc1 | Homo sapiens | CHEMBL712595 | assay format |
| CHEMBL133832 |  |
IC50 | = | 2.0 | nM | 462.85 | O=C(Nc1cc2ccccc2cc1Oc1ccc(C(=O)O)c(C(=O)O)c1)c1cc(Cl)ccn1 | Homo sapiens | CHEMBL680561 | assay format |
| CHEMBL440528 |  |
IC50 | = | 2.0 | nM | 458.43 | COc1ccnc(C(=O)Nc2cc3ccccc3cc2Oc2ccc(C(=O)O)c(C(=O)O)c2)c1 | Homo sapiens | CHEMBL680561 | assay format |
| CHEMBL394526 |  |
IC50 | = | 2.0 | nM | 454.33 | O=C(NC1Cc2ccccc2N(C[C@@H](O)CO)C1=O)c1cc2sc(Cl)c(Cl)c2[nH]1 | Homo sapiens | CHEMBL889956 | single protein format |
| CHEMBL132191 |  |
IC50 | = | 3.0 | nM | 423.34 | O=C(Nc1ccccc1Oc1ccc(C(=O)O)c(C(=O)O)c1)c1cc([N+](=O)[O-])ccn1 | Homo sapiens | CHEMBL680561 | assay format |
| CHEMBL471266 |  |
IC50 | = | 3.0 | nM | 561.68 | COc1ccc(-c2ccc(C(=O)N[C@H](C(=O)O)[C@@H](C)OC(C)(C)C)c(NC(=O)Nc3c(C)cc(C)cc3C)c2)cc1 | Homo sapiens | CHEMBL1027304 | assay format |
| CHEMBL458655 |  |
IC50 | = | 3.0 | nM | 589.71 | Cc1cc(CC2CC2)cc(C)c1NC(=O)Nc1cc(-c2cccc(F)c2)ccc1C(=O)N[C@H](C(=O)O)[C@@H](C)OC(C)(C)C | Homo sapiens | CHEMBL1027304 | assay format |
| CHEMBL115341 |  |
IC50 | = | 4.0 | nM | 529.97 | COc1ccc(CN2C(C)=C(C(=O)OC(C)C)C(c3ccccc3Cl)C(C(=O)O)=C2C(=O)O)cc1OC | Homo sapiens | CHEMBL712595 | assay format |
| CHEMBL133274 |  |
IC50 | = | 4.0 | nM | 456.45 | CCc1ccnc(C(=O)Nc2cc3ccccc3cc2Oc2ccc(C(=O)O)c(C(=O)O)c2)c1 | Homo sapiens | CHEMBL680561 | assay format |
| CHEMBL459792 |  |
IC50 | = | 4.0 | nM | 513.61 | Cc1cc(CC2CC2)cc(C)c1NC(=O)Nc1cc(F)ccc1C(=O)N[C@H](C(=O)O)[C@@H](C)OC(C)(C)C | Homo sapiens | CHEMBL1027304 | assay format |
| CHEMBL506011 |  |
IC50 | = | 4.0 | nM | 589.73 | CCCc1cc(C)c(NC(=O)Nc2cc(-c3ccc(OC)cc3)ccc2C(=O)N[C@H](C(=O)O)[C@@H](C)OC(C)(C)C)c(C)c1 | Homo sapiens | CHEMBL1027304 | assay format |
| CHEMBL449986 |  |
IC50 | = | 4.0 | nM | 577.7 | CCCc1cc(C)c(NC(=O)Nc2cc(-c3cccc(F)c3)ccc2C(=O)N[C@H](C(=O)O)[C@@H](C)OC(C)(C)C)c(C)c1 | Homo sapiens | CHEMBL1027304 | assay format |
| CHEMBL217994 |  |
IC50 | = | 5.0 | nM | 410.33 | CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1 | Homo sapiens | CHEMBL909563 | assay format |
| CHEMBL480195 |  |
IC50 | = | 5.0 | nM | 598.41 | O=C(Nc1cc2ccccc2cc1C(=O)N[C@H](C(=O)O)C1CCCCC1)Nc1c(Cl)cc(OC(F)(F)F)cc1Cl | Homo sapiens | CHEMBL1034792 | assay format |
| CHEMBL423509 |  |
IC50 | = | 5.0 | nM | 514.92 | CC1=C(C(=O)OC(C)C)C(c2ccccc2Cl)C(C(=O)O)=C(C(=O)O)N1Cc1cccc([N+](=O)[O-])c1 | Homo sapiens | CHEMBL712595 | assay format |
| CHEMBL481534 |  |
IC50 | = | 5.0 | nM | 501.63 | Cc1cc(C)c(NC(=O)Nc2cc3ccccc3cc2C(=O)NC2(C(=O)O)CCCCCCC2)c(C)c1 | Homo sapiens | CHEMBL1034792 | assay format |
| CHEMBL434025 |  |
IC50 | = | 6.0 | nM | 503.39 | O=C(NCCOCCOCCNC(=O)c1cc2cc(Cl)ccc2[nH]1)c1cc2cc(Cl)ccc2[nH]1 | Homo sapiens | CHEMBL3378175 | single protein format |
| CHEMBL472140 |  |
IC50 | = | 6.0 | nM | 487.6 | Cc1cc(C)c(NC(=O)Nc2cc3ccccc3cc2C(=O)N[C@H](C(=O)O)C2CCCCC2)c(C)c1 | Homo sapiens | CHEMBL1034792 | assay format |