P06730 | IF4E_HUMAN | Eukaryotic translation initiation factor 4E (EIF4E)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01652 | IF4E - Eukaryotic initiation factor 4E | 38~197 |
3D structures mapped by conservation among orthologs
[ Domain: "Translation initiation factor eIF4e and phosphothreonine lyase" // IF4E ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4073443 |  |
IC50 | = | 6.0 | nM | 340.39 | Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 | Homo sapiens | CHEMBL5137651 | cell-based format |
| CHEMBL2046918 |  |
IC50 | = | 16.0 | nM | 525.84 | CNc1nc2nc(-c3ccc(C(F)(F)P(=O)(O)O)cc3)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL2051182 | assay format |
| CHEMBL2046906 |  |
IC50 | = | 41.0 | nM | 562.27 | Nc1nc2c(c(=O)[nH]1)[n+](CCOc1ccc(Br)cc1)cn2[C@@H]1O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL2051182 | assay format |
| CHEMBL2046915 |  |
IC50 | = | 51.0 | nM | 557.88 | CC1(C)O[C@@H]2[C@H](O1)[C@@H](COP(=O)([O-])O)O[C@H]2n1c[n+](CCOc2ccc(Cl)cc2)c2c(=O)[nH]c(N)nc21 | Homo sapiens | CHEMBL2051182 | assay format |
| CHEMBL2046910 |  |
IC50 | = | 56.0 | nM | 535.81 | Nc1nc2c(c(=O)[nH]1)[n+](CCOc1ccc(Cl)c(F)c1)cn2[C@@H]1O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL2051182 | assay format |
| CHEMBL2046905 |  |
IC50 | = | 59.0 | nM | 517.82 | Nc1nc2c(c(=O)[nH]1)[n+](CCOc1ccc(Cl)cc1)cn2[C@@H]1O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL2051182 | assay format |
| CHEMBL2046916 |  |
IC50 | = | 95.0 | nM | 475.83 | CNc1nc2nc(-c3ccc(P(=O)(O)O)cc3)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL2051182 | assay format |
| CHEMBL2046912 |  |
IC50 | = | 117.0 | nM | 527.81 | Nc1nc2c(c(=O)[nH]1)[n+](Cc1cc3cc(Cl)ccc3o1)cn2[C@@H]1O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL2051182 | assay format |
| CHEMBL2046908 |  |
IC50 | = | 125.0 | nM | 508.38 | N#Cc1ccc(OCC[n+]2cn([C@@H]3O[C@H](COP(=O)([O-])O)[C@@H](O)[C@H]3O)c3nc(N)[nH]c(=O)c32)cc1 | Homo sapiens | CHEMBL2051182 | assay format |
| CHEMBL2046917 |  |
IC50 | = | 160.0 | nM | 489.86 | CNc1nc2nc(-c3ccc(CP(=O)(O)O)cc3)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL2051182 | assay format |
| CHEMBL4587832 |  |
IC50 | = | 200.0 | nM | 378.43 | CC(C)Oc1cc(-c2cncc(-c3cnn(C4COC4)c3)c2)ccc1C(N)=O | Homo sapiens | CHEMBL5357185 | cell-based format |
| CHEMBL3806189 |  |
IC50 | = | 280.0 | nM | 584.62 | CN1CCN(Cc2ccc(NC(=O)CNc3ccc(-c4ccc(NC(=O)C5CC5)nc4)cc3F)cc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL5357185 | cell-based format |
| CHEMBL4211649 |  |
IC50 | = | 321.0 | nM | 408.46 | N#Cc1ccc(-c2cnc3ccc(-c4ccc(C(=O)N5CCOCC5)cc4)cn23)cc1 | Homo sapiens | CHEMBL5357185 | cell-based format |
| CHEMBL4100554 |  |
IC50 | = | 430.0 | nM | 309.33 | O=C1NCc2cc(Nc3cc(NC(=O)C4CC4)ncn3)ccc21 | Homo sapiens | CHEMBL5137651 | cell-based format |
| CHEMBL3659374 |  |
IC50 | = | 500.0 | nM | 471.32 | O=C(O)c1cc(-c2nc(-c3ccc(Cl)c(Cl)c3)cs2)ccc1-c1ccccc1[N+](=O)[O-] | Homo sapiens | CHEMBL3705829 | assay format |
| CHEMBL3659444 |  |
IC50 | = | 600.0 | nM | 544.77 | O=C(O)c1cc(-c2nc(-c3ccc(Cl)c(Cl)c3)cs2)ccc1-c1cc(OC(F)(F)F)ccc1Cl | Homo sapiens | CHEMBL3705829 | assay format |
| CHEMBL3663619 |  |
IC50 | = | 700.0 | nM | 492.79 | Cc1ccc(Cl)c(-c2ccc(-c3nc(-c4ccc(Cl)c(Cl)c4)cs3)cc2C(=O)O)c1F | Homo sapiens | CHEMBL3705829 | assay format |
| CHEMBL1234303 |  |
IC50 | = | 720.0 | nM | 538.22 | C[n+]1cn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c21 | Homo sapiens | CHEMBL5253740 | single protein format |
| CHEMBL3663603 |  |
IC50 | = | 800.0 | nM | 512.31 | O=C(O)c1cc(-c2nc(-c3ccc(Cl)c(Cl)c3)cs2)ccc1-c1ccc(F)cc1C(F)(F)F | Homo sapiens | CHEMBL3705829 | assay format |
| CHEMBL3659436 |  |
IC50 | = | 970.0 | nM | 573.5 | CC(NC(=O)c1ccc(-c2ccc(-c3nc(-c4ccc(Cl)c(Cl)c4)cs3)cc2C(=O)O)cc1)c1ccccc1 | Homo sapiens | CHEMBL3705829 | assay format |