P06493 | CDK1_HUMAN | Cyclin-dependent kinase 1 (CDK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 4~287 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL194540 |  |
IC50 | = | 0.1 | nM | 449.42 | NS(=O)(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc4[nH]cnc4c3)n2)cc1 | Homo sapiens | CHEMBL827874 | single protein format |
| CHEMBL248713 |  |
IC50 | = | 0.7 | nM | 387.42 | CCNCc1cncc(-c2cnc3[nH]nc(-c4nc5cc(F)ccc5[nH]4)c3c2)c1 | Homo sapiens | CHEMBL888275 | single protein format |
| CHEMBL561334 |  |
IC50 | = | 0.8 | nM | 283.36 | C[C@@H]1CNc2c(sc3ccc4ncccc4c23)C(=O)N1 | Homo sapiens | CHEMBL1061559 | single protein format |
| CHEMBL429478 |  |
IC50 | = | 0.8 | nM | 399.46 | CCNCc1cncc(-c2cnc3[nH]nc(-c4nc5cc(OC)ccc5[nH]4)c3c2)c1 | Homo sapiens | CHEMBL888275 | single protein format |
| CHEMBL194721 |  |
IC50 | = | 0.9 | nM | 404.78 | FC(F)(F)c1cnc(Nc2ccc3[nH]cnc3c2)nc1Nc1ccccc1Cl | Homo sapiens | CHEMBL827874 | single protein format |
| CHEMBL215803 |  |
IC50 | = | 1.0 | nM | 403.44 | C[C@@H]1C[C@H]2CN1CCn1nc3c(cccc3c1O)-c1nc3c(cccc3nc1O)O2 | Homo sapiens | CHEMBL910892 | single protein format |
| CHEMBL462385 |  |
IC50 | < | 1.0 | nM | 443.5 | Cc1ncc(-c2nc(Nc3ccc(C(=O)NCCN(C)C)c(F)c3)ncc2F)n1C(C)C | Homo sapiens | CHEMBL1018124 | single protein format |
| CHEMBL557318 |  |
IC50 | = | 1.0 | nM | 272.33 | C[C@@H]1CNc2c(sc3ccc4occc4c23)C(=O)N1 | Homo sapiens | CHEMBL1061559 | single protein format |
| CHEMBL248712 |  |
IC50 | = | 1.1 | nM | 405.41 | CCNCc1cncc(-c2cnc3[nH]nc(-c4nc5cc(F)c(F)cc5[nH]4)c3c2)c1 | Homo sapiens | CHEMBL888275 | single protein format |
| CHEMBL249303 |  |
IC50 | = | 1.8 | nM | 447.55 | CCN(CC)Cc1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc6ccccc56)cc34)nc12 | Homo sapiens | CHEMBL888275 | single protein format |
| CHEMBL3648111 |  |
IC50 | = | 2.0 | nM | 444.36 | COc1cc(Nc2ncc(Br)c(N[C@H](C)[C@@H](C)O)n2)ccc1S(C)(=N)=O | Homo sapiens | CHEMBL3707822 | single protein format |
| CHEMBL192216 |  |
IC50 | = | 2.0 | nM | 351.33 | CC(C)COc1nc(Nc2ccc3[nH]cnc3c2)ncc1C(F)(F)F | Homo sapiens | CHEMBL827874 | single protein format |
| CHEMBL3545083 |  |
IC50 | = | 2.0 | nM | 545.64 | COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 | Homo sapiens | CHEMBL5146300 | single protein format |
| CHEMBL3648115 |  |
IC50 | = | 2.0 | nM | 458.38 | COc1cc(Nc2ncc(Br)c(N[C@H](C)C(C)(C)O)n2)ccc1S(C)(=N)=O | Homo sapiens | CHEMBL3707822 | single protein format |
| CHEMBL455657 |  |
IC50 | = | 2.0 | nM | 437.52 | CN[C@H]1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4cnc(C)n4C(C)C)n3)cc2)C1 | Homo sapiens | CHEMBL1018124 | single protein format |
| CHEMBL400749 |  |
IC50 | = | 2.5 | nM | 399.46 | CNCc1cncc(-c2cnc3[nH]nc(-c4nc5c(COC)cccc5[nH]4)c3c2)c1 | Homo sapiens | CHEMBL888275 | single protein format |
| CHEMBL410883 |  |
IC50 | = | 2.8 | nM | 359.37 | NC(=O)c1ccc2c(c1)/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 | Homo sapiens | CHEMBL666140 | single protein format |
| CHEMBL3648112 |  |
IC50 | = | 3.0 | nM | 444.36 | COc1cc(Nc2ncc(Br)c(N[C@H](C)[C@H](C)O)n2)ccc1S(C)(=N)=O | Homo sapiens | CHEMBL3707822 | single protein format |
| CHEMBL3644026 |  |
IC50 | = | 3.0 | nM | 435.42 | C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=O)(=O)CCO)cc2)ncc1C(F)(F)F | Homo sapiens | CHEMBL3705517 | single protein format |
| CHEMBL2029900 |  |
IC50 | = | 3.0 | nM | 450.55 | CN1CCN(C(=O)c2cc(Nc3ncc4cc(/C=N/O)n(C5CCCC5)c4n3)cn2C)CC1 | Homo sapiens | CHEMBL2032823 | single protein format |