P06400 | RB_HUMAN | Retinoblastoma-associated protein (RB1)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01857 | RB_B | 646–765 | |
| PF01858 | RB_A | 373–573 | |
| PF08934 | Rb_C | 768–925 | |
| PF11934 | DUF3452 | 113–226 |
3D structures mapped by conservation among orthologs
[ Domain: "Cyclin-like" // DUF3452 ]
[ Domain: "Cyclin-like" // RB_A ]
[ Domain: "Cyclin-like" // KOG1010 ]
[ Domain: "Cyclin-like" // RB_B ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 66.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4034785 | cell-based format |
| CHEMBL515631 |  |
IC50 | = | 200.0 | nM | 409.49 | CCCOc1cnc(CN/C=C2\C(=O)NC(=O)c3ccc(C(C)(C)C)cc32)cc1O | Homo sapiens | CHEMBL1011869 | cell-based format |
| CHEMBL5285163 |  |
IC50 | = | 270.0 | nM | 435.55 | CS(=O)(=O)N1CCC(Nc2ncc3cc(CCO)c(=O)n(C4CCCC4)c3n2)CC1 | Homo sapiens | CHEMBL5236943 | cell-based format |
| CHEMBL490451 |  |
IC50 | = | 370.0 | nM | 487.25 | O=C1NC(=O)c2ccc(I)cc2/C1=C/NCc1ccn(-c2ccoc2)c(=O)c1 | Homo sapiens | CHEMBL1011869 | cell-based format |
| CHEMBL504547 |  |
IC50 | = | 610.0 | nM | 486.26 | O=C1NC(=O)c2ccc(I)cc2/C1=C/NCc1ccc(-c2ccoc2)c(O)c1 | Homo sapiens | CHEMBL1011869 | cell-based format |