P06241 | FYN_HUMAN | Tyrosine-protein kinase Fyn (FYN)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 149~231 | |
| PF00018 | SH3_1 - SH3 domain | 88~135 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 271~520 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // SH3_1 ]
[ Domain: "SH2" // SH2 ]
[ Domain: "SH2" // SH2,RNAse_Pc_like ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5416410 |  |
IC50 | = | 0.2 | nM | 506.03 | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O | Homo sapiens | CHEMBL912340 | single protein format |
| CHEMBL45177 |  |
IC50 | = | 0.3 | nM | 482.63 | CN1CCN([C@H]2CC[C@H](n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 | Homo sapiens | CHEMBL4274923 | single protein format |
| CHEMBL1171837 |  |
IC50 | = | 0.36 | nM | 532.57 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | Homo sapiens | CHEMBL4721783 | single protein format |
| CHEMBL285063 |  |
IC50 | = | 1.0 | nM | 369.22 | C=CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 | Homo sapiens | CHEMBL1226207 | assay format |
| CHEMBL515414 |  |
IC50 | = | 1.0 | nM | 342.37 | Cc1ccc(-c2c(C(=O)CF)n(CCCO)c3ncnc(N)c23)cc1 | Homo sapiens | CHEMBL1017822 | assay format |
| CHEMBL364623 |  |
IC50 | = | 1.0 | nM | 373.87 | Cc1cc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)nc(C)n1 | Homo sapiens | CHEMBL829344 | single protein format |
| CHEMBL288441 |  |
IC50 | = | 1.8 | nM | 530.46 | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl | Homo sapiens | CHEMBL1244328 | single protein format |
| CHEMBL3335371 |  |
IC50 | = | 2.0 | nM | 429.52 | CC(=O)Nc1cc(Oc2ccc3c(c2)nc(Nc2cccc(C(C)(C)C)c2)n3C)ccn1 | Homo sapiens | CHEMBL3636906 | single protein format |
| CHEMBL3824089 |  |
IC50 | = | 2.1 | nM | 510.64 | COc1cc(-c2nn(CCN3CCC(N(C)C)CC3)c3ncnc(N)c23)ccc1NC(=O)OC(C)(C)C | Homo sapiens | CHEMBL3826739 | single protein format |
| CHEMBL1997924 |  |
IC50 | = | 2.17 | nM | 362.46 | c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 | Homo sapiens | CHEMBL5156507 | single protein format |
| CHEMBL1221769 |  |
IC50 | = | 3.0 | nM | 340.39 | C=CC(=O)Nc1ccc2ncnc(Nc3ccc4ccccc4c3)c2c1 | Homo sapiens | CHEMBL1226207 | assay format |
| CHEMBL272888 |  |
IC50 | = | 3.0 | nM | 589.62 | Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 | Homo sapiens | CHEMBL951119 | single protein format |
| CHEMBL88009 |  |
IC50 | = | 4.0 | nM | 468.97 | Cc1cc(Nc2nc3ccc(C(=O)Nc4c(C)cccc4Cl)cc3s2)nc(NCCO)n1 | Homo sapiens | CHEMBL680971 | single protein format |
| CHEMBL1163016 |  |
IC50 | = | 5.0 | nM | 499.6 | CC1(C)CC(NC(=O)c2cccc(-c3cc4nccc(Nc5cccc(O)c5)n4n3)c2)CC(C)(C)N1[O] | Homo sapiens | CHEMBL1046245 | single protein format |
| CHEMBL1221699 |  |
IC50 | = | 5.0 | nM | 290.33 | C=CC(=O)Nc1ccc2ncnc(Nc3ccccc3)c2c1 | Homo sapiens | CHEMBL1226206 | assay format |
| CHEMBL470808 |  |
IC50 | = | 5.0 | nM | 429.52 | CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2cccc(C(C)(C)C)c2)n3C)ccn1 | Homo sapiens | CHEMBL3636906 | single protein format |
| CHEMBL3426225 |  |
IC50 | = | 5.0 | nM | 576.63 | CCn1nc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)c2c(N)ncnc21 | Homo sapiens | CHEMBL3429870 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 5.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL919498 | cell-based format |
| CHEMBL4798527 |  |
IC50 | = | 6.0 | nM | 548.57 | Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 | Homo sapiens | CHEMBL4766146 | single protein format |
| CHEMBL3647967 |  |
IC50 | = | 7.1 | nM | 454.53 | C=CC(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 | Homo sapiens | CHEMBL3887540 | single protein format |