P06239 | LCK_HUMAN | Tyrosine-protein kinase Lck (LCK)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 127~209 | |
| PF00018 | SH3_1 - SH3 domain | 67~112 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 245~493 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // SH3_1 ]
[ Domain: "SH2" // SH2 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL215969 |  |
IC50 | = | 0.01 | nM | 450.46 | CNc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4C)ccc3C)ccc2n1 | Homo sapiens | CHEMBL913225 | single protein format |
| CHEMBL566813 |  |
IC50 | = | 0.06 | nM | 506.61 | C[C@H](Nc1nccc(-n2cnc3ccccc32)n1)[C@@H]1CN(C(=O)Nc2cccc3ccccc23)CCN1C | Homo sapiens | CHEMBL1049046 | single protein format |
| CHEMBL212181 |  |
IC50 | = | 0.07 | nM | 476.5 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2C)cc1-c1ccc2nc(NC3CC3)ncc2c1 | Homo sapiens | CHEMBL913225 | single protein format |
| CHEMBL566284 |  |
IC50 | = | 0.07 | nM | 599.7 | C[C@H](Nc1nccc(-n2cnc3cc(-c4ccnc(N)n4)ccc32)n1)[C@@H]1CN(C(=O)Nc2cccc3ccccc23)CCN1C | Homo sapiens | CHEMBL1049046 | single protein format |
| CHEMBL569496 |  |
IC50 | = | 0.07 | nM | 520.64 | CCN1CCN(C(=O)Nc2cccc3ccccc23)C[C@H]1[C@H](C)Nc1nccc(-n2cnc3ccccc32)n1 | Homo sapiens | CHEMBL1049046 | single protein format |
| CHEMBL572197 |  |
IC50 | = | 0.12 | nM | 583.7 | C[C@H](Nc1nccc(-n2cnc3cc(-c4ccncc4)ccc32)n1)[C@@H]1CN(C(=O)Nc2cccc3ccccc23)CCN1C | Homo sapiens | CHEMBL1049046 | single protein format |
| CHEMBL568762 |  |
IC50 | = | 0.2 | nM | 548.7 | CC(C)CN1CCN(C(=O)Nc2cccc3ccccc23)C[C@H]1[C@H](C)Nc1nccc(-n2cnc3ccccc32)n1 | Homo sapiens | CHEMBL1049046 | single protein format |
| CHEMBL385698 |  |
IC50 | < | 0.2 | nM | 403.9 | Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cccc(NCCO)n2)s1 | Homo sapiens | CHEMBL910552 | single protein format |
| CHEMBL215943 |  |
IC50 | = | 0.2 | nM | 535.57 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1 | Homo sapiens | CHEMBL913225 | single protein format |
| CHEMBL385937 |  |
IC50 | = | 0.2 | nM | 422.41 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(N)ncc2c1 | Homo sapiens | CHEMBL913225 | single protein format |
| CHEMBL386118 |  |
IC50 | = | 0.2 | nM | 418.91 | Cc1nc(NCCO)cc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)n1 | Homo sapiens | CHEMBL910552 | single protein format |
| CHEMBL565263 |  |
IC50 | = | 0.2 | nM | 569.67 | C[C@H](Nc1nccc(-n2cnc3ccccc32)n1)[C@@H]1CN(C(=O)Nc2cccc3ccccc23)CCN1c1ccncc1 | Homo sapiens | CHEMBL1049046 | single protein format |
| CHEMBL569052 |  |
IC50 | = | 0.25 | nM | 506.61 | CC(Nc1nccc(-n2cnc3ccccc32)n1)C1CN(C(=O)Nc2cccc3ccccc23)CCN1C | Homo sapiens | CHEMBL1049046 | single protein format |
| CHEMBL1171837 |  |
IC50 | = | 0.28 | nM | 532.57 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | Homo sapiens | CHEMBL4721776 | single protein format |
| CHEMBL212128 |  |
IC50 | = | 0.3 | nM | 436.44 | CNc1ncc2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 | Homo sapiens | CHEMBL913225 | single protein format |
| CHEMBL212964 |  |
IC50 | = | 0.3 | nM | 436.44 | CNc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 | Homo sapiens | CHEMBL913225 | single protein format |
| CHEMBL427233 |  |
IC50 | = | 0.3 | nM | 408.51 | CNc1ncc2cc(-c3cc(C(=O)Nc4cccc5c4CCC5)ccc3C)ccc2n1 | Homo sapiens | CHEMBL913225 | single protein format |
| CHEMBL405630 |  |
IC50 | = | 0.3 | nM | 325.4 | Cc1cccc(C)c1NC(=O)c1cnc(Nc2cccnn2)s1 | Homo sapiens | CHEMBL910552 | single protein format |
| CHEMBL607366 |  |
IC50 | = | 0.3 | nM | 455.52 | NCCOc1ccc2c(c1)Nc1c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn1CC2 | Homo sapiens | CHEMBL1049477 | single protein format |
| CHEMBL429582 |  |
IC50 | = | 0.4 | nM | 422.41 | Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccc2nc(N)ncc2c1 | Homo sapiens | CHEMBL951931 | single protein format |