P06213 | INSR_HUMAN | Insulin receptor (INSR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 863~941 | |
| PF00757 | Furin-like - Furin-like cysteine rich region | 179~340 | |
| PF01030 | Recep_L_domain - Receptor L domain | 52~163 | |
| PF01030 | Recep_L_domain - Receptor L domain | 359~470 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 1023~1289 | |
| PF17870 | Insulin_TMD - Insulin receptor trans-membrane segment | 940~987 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3_1 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // UNK_F_TYPE ]
[ Domain: "Leucine-rich repeats" // Recep_L_domain ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "Growth factor receptor domain" // Furin-like_5 ]
[ Domain: "Insulin receptor transmembrane segment" // KOG4258_like ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL514873 |  |
IC50 | = | 0.4 | nM | 506.59 | COc1cc2c(cc1Nc1nc(Nc3ccsc3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 | Homo sapiens | CHEMBL1025724 | single protein format |
| CHEMBL515519 |  |
IC50 | = | 0.8 | nM | 490.52 | COc1cc2c(cc1Nc1nc(Nc3ccoc3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 | Homo sapiens | CHEMBL1025724 | single protein format |
| CHEMBL3824326 |  |
IC50 | = | 0.88 | nM | 444.86 | COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(C)=O)n1 | Homo sapiens | CHEMBL3824711 | single protein format |
| CHEMBL5182271 |  |
IC50 | = | 1.0 | nM | 527.68 | COCCN1CCN(CCn2ccc(Nc3ncc4c(n3)C(C)Cc3nn(C)c(-c5ccccc5)c3-4)n2)CC1 | Homo sapiens | CHEMBL5096586 | cell-based format |
| CHEMBL507625 |  |
IC50 | = | 1.6 | nM | 518.6 | COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 | Homo sapiens | CHEMBL1033171 | single protein format |
| CHEMBL575448 |  |
IC50 | = | 1.7 | nM | 461.51 | C[C@@]1(C(=O)Nc2ccc(F)nc2)CCCN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1 | Homo sapiens | CHEMBL4330203 | single protein format |
| CHEMBL464552 |  |
IC50 | = | 1.8 | nM | 532.58 | CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 | Homo sapiens | CHEMBL1033171 | single protein format |
| CHEMBL3608524 |  |
IC50 | = | 2.0 | nM | 502.04 | COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCNCC2 | Homo sapiens | CHEMBL3610968 | single protein format |
| CHEMBL4092174 |  |
IC50 | = | 2.1 | nM | 543.09 | COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCN1CCNCC21 | Homo sapiens | CHEMBL4017793 | single protein format |
| CHEMBL3824301 |  |
IC50 | = | 2.16 | nM | 550.11 | COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(C)=O)n1 | Homo sapiens | CHEMBL3824711 | single protein format |
| CHEMBL4071384 |  |
IC50 | = | 2.2 | nM | 557.08 | COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)C1CNCC(=O)N1CC2 | Homo sapiens | CHEMBL4017793 | single protein format |
| CHEMBL4081925 |  |
IC50 | = | 2.8 | nM | 557.08 | COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCN1C(=O)CNCC21 | Homo sapiens | CHEMBL4017793 | single protein format |
| CHEMBL370967 |  |
IC50 | = | 3.0 | nM | 295.43 | CN(C)c1ccc(/C=C/c2sc3ccccc3[n+]2C)cc1 | Homo sapiens | CHEMBL1947451 | single protein format |
| CHEMBL1760035 |  |
IC50 | = | 3.0 | nM | 403.44 | COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC | Homo sapiens | CHEMBL1764778 | single protein format |
| CHEMBL3824246 |  |
IC50 | = | 3.4 | nM | 551.1 | COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 | Homo sapiens | CHEMBL3824711 | single protein format |
| CHEMBL1086731 |  |
IC50 | = | 4.0 | nM | 497.63 | Cc1ccc(NC(=O)c2ccc(C(C)(C)C)s2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 | Homo sapiens | CHEMBL1113982 | cell-based format |
| CHEMBL1644798 |  |
IC50 | = | 4.0 | nM | 436.9 | CN1C(=O)CCCc2cc(Nc3ncc(Cl)c(Nc4ccccc4C(N)=O)n3)ccc21 | Homo sapiens | CHEMBL1649021 | single protein format |
| CHEMBL3823256 |  |
IC50 | = | 4.7 | nM | 480.91 | COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(C)(=O)=O)n1 | Homo sapiens | CHEMBL3824711 | single protein format |
| CHEMBL3822475 |  |
IC50 | = | 5.1 | nM | 586.16 | COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(C)(=O)=O)n1 | Homo sapiens | CHEMBL3824711 | single protein format |
| CHEMBL3608523 |  |
IC50 | = | 5.1 | nM | 502.04 | COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CNCCC2 | Homo sapiens | CHEMBL3610968 | single protein format |