P05771 | KPCB_HUMAN | Protein kinase C beta type (PRKCB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 344~586 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 37~87 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 102~153 | |
| PF00168 | C2 - C2 domain | 173~277 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 623~662 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2151411 |  |
IC50 | = | 0.2 | nM | 452.52 | Cc1cccc2c(C3=C(c4nc(N5CCN(C)CC5)nc5ccccc45)C(=O)NC3=O)c[nH]c12 | Homo sapiens | CHEMBL2156012 | single protein format |
| CHEMBL1996510 |  |
IC50 | = | 0.6 | nM | 424.46 | O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 | Homo sapiens | CHEMBL2156012 | single protein format |
| CHEMBL4102228 |  |
IC50 | = | 0.7 | nM | 429.91 | CN(C)Cc1ccc2ccc(Cl)c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2c1 | Homo sapiens | CHEMBL4004541 | single protein format |
| CHEMBL2153750 |  |
IC50 | = | 1.2 | nM | 456.48 | CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3cc(F)ccc3n2)CC1 | Homo sapiens | CHEMBL2156012 | single protein format |
| CHEMBL4072879 |  |
IC50 | = | 1.4 | nM | 429.91 | CNCc1ccc2ccc(Cl)c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c2c1 | Homo sapiens | CHEMBL4004541 | single protein format |
| CHEMBL2151415 |  |
IC50 | = | 1.4 | nM | 438.49 | Cn1cc(C2=C(c3nc(N4CCNCC4)nc4ccccc34)C(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL2156012 | single protein format |
| CHEMBL2236794 |  |
IC50 | = | 1.4 | nM | 372.43 | NC[C@H]1Cc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 | Homo sapiens | CHEMBL3063098 | single protein format |
| CHEMBL7463 |  |
IC50 | = | 1.6 | nM | 412.49 | CN(C)CCCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL1040087 | single protein format |
| CHEMBL568580 |  |
IC50 | = | 1.8 | nM | 436.52 | CN1CCN(c2cc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3c2)CC1 | Homo sapiens | CHEMBL1040087 | single protein format |
| CHEMBL2153748 |  |
IC50 | = | 2.0 | nM | 437.5 | CN1CCN(c2cc3ccccc3c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)n2)CC1 | Homo sapiens | CHEMBL2156012 | single protein format |
| CHEMBL565612 |  |
IC50 | = | 2.0 | nM | 438.49 | CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 | Homo sapiens | CHEMBL1040087 | single protein format |
| CHEMBL302449 |  |
IC50 | = | 2.0 | nM | 378.44 | Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O | Homo sapiens | CHEMBL939360 | single protein format |
| CHEMBL2236799 |  |
IC50 | = | 2.0 | nM | 414.51 | CN(C)C[C@H]1CCn2c(c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc32)C1 | Homo sapiens | CHEMBL3063098 | single protein format |
| CHEMBL540357 |  |
IC50 | = | 2.0 | nM | 500.42 | Br.N=C(N)SCCCn1cc(C2=C(Nc3ccccc3)C(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL828576 | single protein format |
| CHEMBL4089217 |  |
IC50 | = | 2.0 | nM | 455.95 | Cn1cc(C2=C(c3c(Cl)ccc4ccc(CN5CCC5)cc34)C(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL4004541 | single protein format |
| CHEMBL565632 |  |
IC50 | = | 2.1 | nM | 425.49 | CN(C)CCOc1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc2c1 | Homo sapiens | CHEMBL1040087 | single protein format |
| CHEMBL2236809 |  |
IC50 | = | 2.2 | nM | 386.46 | CNC[C@H]1Cc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 | Homo sapiens | CHEMBL3063098 | single protein format |
| CHEMBL2236793 |  |
IC50 | = | 2.4 | nM | 400.48 | CCNC[C@H]1Cc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 | Homo sapiens | CHEMBL3063098 | single protein format |
| CHEMBL4083319 |  |
IC50 | = | 2.9 | nM | 457.96 | CC(C)NCc1ccc2ccc(Cl)c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c2c1 | Homo sapiens | CHEMBL4004541 | single protein format |
| CHEMBL350335 |  |
IC50 | = | 3.0 | nM | 460.58 | N=C(N)SCCCn1c(-c2cc3ccccc3s2)c(C2=CC(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL761751 | single protein format |