P05412 | JUN_HUMAN | Transcription factor Jun (JUN)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00170 | bZIP_1 - bZIP transcription factor | 250~313 | |
| PF03957 | Jun - Jun-like transcription factor | 6~240 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL337665 |  |
IC50 | = | 3.0 | nM | 366.4 | COc1ccc2nc(-c3cccs3)nc(NN3C(=O)C=C(C)C3=O)c2c1 | Homo sapiens | CHEMBL3367171 | cell-based format |
| CHEMBL129857 |  |
IC50 | = | 8.0 | nM | 366.4 | COc1cccc2nc(-c3cccs3)nc(NN3C(=O)C=C(C)C3=O)c12 | Homo sapiens | CHEMBL3367171 | cell-based format |
| CHEMBL43549 |  |
IC50 | = | 20.0 | nM | 358.38 | CCOC(=O)c1cnc(-c2cccs2)nc1NN1C(=O)C=C(C)C1=O | Homo sapiens | CHEMBL3367171 | cell-based format |
| CHEMBL1761563 |  |
IC50 | = | 20.0 | nM | 464.53 | Cc1ccc(-c2cccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc23)cn1 | Homo sapiens | CHEMBL1763333 | single protein format |
| CHEMBL132495 |  |
IC50 | = | 20.0 | nM | 383.68 | Cc1nc(Cl)ncc1C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL645946 | cell-based format |
| CHEMBL487194 |  |
IC50 | = | 32.0 | nM | 478.54 | CCC(C)C(=O)O[C@H]1C(=O)O[C@@H]2C[C@H]3C(C)=CC(=O)[C@@H](O)[C@]3(C)[C@H]3[C@]4(O)OC[C@]32[C@@H]1[C@@H](C)[C@H]4O | Homo sapiens | CHEMBL1061338 | cell-based format |
| CHEMBL85822 |  |
IC50 | = | 35.0 | nM | 318.33 | CCOC(=O)c1cnc(N(C)N2C(=O)C=C(C)C2=O)nc1CC | Homo sapiens | CHEMBL3367171 | cell-based format |
| CHEMBL1761561 |  |
IC50 | = | 40.0 | nM | 445.49 | Cc1ccc(-c2ncn(-c3ccc(Nc4ncc5ccc(-c6cn[nH]c6)cc5n4)cc3)n2)cn1 | Homo sapiens | CHEMBL1763333 | single protein format |
| CHEMBL1761583 |  |
IC50 | = | 40.0 | nM | 529.61 | Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2-c2ccccc2)cn1 | Homo sapiens | CHEMBL1763333 | single protein format |
| CHEMBL1761582 |  |
IC50 | = | 40.0 | nM | 533.6 | Cn1cc(-c2ccc3cnc(Nc4ccc(-n5cnc(N6CCOCC6)n5)cc4)nc3c2-c2cnn(C)c2)cn1 | Homo sapiens | CHEMBL1763333 | single protein format |
| CHEMBL458347 |  |
IC50 | = | 40.0 | nM | 494.54 | CC[C@](C)(O)C(=O)O[C@H]1C(=O)O[C@@H]2C[C@H]3C(C)=CC(=O)[C@@H](O)[C@]3(C)[C@H]3[C@@]4(O)OC[C@]32[C@@H]1[C@@H](C)[C@H]4O | Homo sapiens | CHEMBL1061338 | cell-based format |
| CHEMBL86615 |  |
IC50 | = | 45.0 | nM | 372.41 | CCOC(=O)c1cnc(NN2C(=O)C=C(C)C2=O)nc1-c1ccc(C)s1 | Homo sapiens | CHEMBL3367171 | cell-based format |
| CHEMBL336546 |  |
IC50 | = | 50.0 | nM | 437.65 | O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(Cl)nc1C(F)(F)F | Homo sapiens | CHEMBL645946 | cell-based format |
| CHEMBL1761584 |  |
IC50 | = | 50.0 | nM | 483.54 | COc1c(-c2cnn(C)c2)ccc2cnc(Nc3ccc(-n4cnc(N5CCOCC5)n4)cc3)nc12 | Homo sapiens | CHEMBL1763333 | single protein format |
| CHEMBL250854 |  |
IC50 | = | 65.0 | nM | 365.43 | COc1ccc2c3c(c4cc(OC)c(O)cc4c2c1)CN1CCC[C@H]1[C@H]3O | Homo sapiens | CHEMBL888216 | cell-based format |
| CHEMBL250474 |  |
IC50 | = | 68.0 | nM | 349.43 | COc1ccc2c3c(c4cc(OC)c(O)cc4c2c1)CN1CCC[C@@H]1C3 | Homo sapiens | CHEMBL888216 | cell-based format |
| CHEMBL564009 |  |
IC50 | = | 71.0 | nM | 478.54 | CC(C)=CC(=O)O[C@@H]1[C@H]2C(C)=C[C@H](O)[C@@H](O)[C@]2(C)[C@H]2[C@]3(O)OC[C@@]24[C@@H]1OC(=O)C[C@H]4[C@@H](C)[C@H]3O | Homo sapiens | CHEMBL1061338 | cell-based format |
| CHEMBL315804 |  |
IC50 | = | 98.0 | nM | 376.29 | CC1=CC(=O)N(Nc2ncc(C(=O)c3ccccc3)c(C(F)(F)F)n2)C1=O | Homo sapiens | CHEMBL3367171 | cell-based format |
| CHEMBL3341912 |  |
IC50 | = | 100.0 | nM | 331.71 | O=C1Nc2cc(C(F)(F)F)ccc2Sc2nc(Cl)ncc21 | Homo sapiens | CHEMBL3367171 | cell-based format |
| CHEMBL131006 |  |
IC50 | = | 100.0 | nM | 421.19 | O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(F)nc1C(F)(F)F | Homo sapiens | CHEMBL645946 | cell-based format |