P05231 | IL6_HUMAN | Interleukin-6 (IL6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00489 | IL6 - Interleukin-6/G-CSF/MGF family | 27~212 |
3D structures mapped by conservation among orthologs
[ Domain: "4-helical cytokines" // IL6 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3647441 |  |
IC50 | = | 1.1 | nM | 522.61 | Cc1ncccc1NC(=O)c1ccc2c(c1)CC[C@@H]1C[C@@](O)(CCC(F)(F)F)CC[C@@]21Cc1ccccc1 | Homo sapiens | CHEMBL3705674 | single protein format |
| CHEMBL3647443 |  |
IC50 | = | 1.1 | nM | 508.54 | Cc1ncccc1NC(=O)c1ccc2c(c1)C(=O)C[C@@H]1C[C@@](O)(C(F)(F)F)CC[C@@]21Cc1ccccc1 | Homo sapiens | CHEMBL3705674 | single protein format |
| CHEMBL3647442 |  |
IC50 | = | 1.3 | nM | 494.56 | Cc1ccncc1NC(=O)c1ccc2c(c1)CC[C@@H]1C[C@@](O)(C(F)(F)F)CC[C@@]21Cc1ccccc1 | Homo sapiens | CHEMBL3705674 | single protein format |
| CHEMBL3647445 |  |
IC50 | = | 2.1 | nM | 510.56 | Cc1c(NC(=O)c2ccc3c(c2)CC[C@@H]2C[C@@](O)(C(F)(F)F)CC[C@@]32Cc2ccccc2)ccc[n+]1[O-] | Homo sapiens | CHEMBL3705674 | single protein format |
| CHEMBL3647447 |  |
IC50 | = | 2.8 | nM | 492.54 | Cc1ncccc1NC(=O)c1ccc2c(c1)C=C[C@@H]1C[C@@](O)(C(F)(F)F)CC[C@@]21Cc1ccccc1 | Homo sapiens | CHEMBL3705674 | single protein format |
| CHEMBL3647440 |  |
IC50 | = | 4.0 | nM | 509.57 | Cc1cnc(NC(=O)c2ccc3c(c2)CC[C@@H]2C[C@@](O)(C(F)(F)F)CC[C@@]32Cc2ccccc2)c(C)n1 | Homo sapiens | CHEMBL3705674 | single protein format |
| CHEMBL131 |  |
IC50 | = | 4.2 | nM | 360.45 | C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO | Homo sapiens | CHEMBL3705674 | single protein format |
| CHEMBL3647446 |  |
IC50 | = | 4.3 | nM | 476.57 | Cc1ncccc1NC(=O)c1ccc2c(c1)CC[C@@H]1C[C@@](O)(C(F)F)CC[C@@]21Cc1ccccc1 | Homo sapiens | CHEMBL3705674 | single protein format |
| CHEMBL3647444 |  |
IC50 | = | 7.0 | nM | 510.56 | Cc1ncccc1NC(=O)c1ccc2c(c1)[C@H](O)C[C@@H]1C[C@@](O)(C(F)(F)F)CC[C@@]21Cc1ccccc1 | Homo sapiens | CHEMBL3705674 | single protein format |
| CHEMBL3358954 |  |
IC50 | = | 23.0 | nM | 515.53 | CCS(=O)(=O)c1cc2cc(C[C@](O)(CC(C)(C)c3ccc(F)cc3C(N)=O)C(F)(F)F)[nH]c2cn1 | Homo sapiens | CHEMBL4882182 | cell-based format |
| CHEMBL3137316 |  |
IC50 | = | 60.0 | nM | 574.54 | Cc1ncccc1NC(=O)c1ccc2c(c1)CC[C@@H]1C[C@@](OP(=O)(O)O)(C(F)(F)F)CC[C@@]21Cc1ccccc1 | Homo sapiens | CHEMBL3705674 | single protein format |
| CHEMBL273019 |  |
IC50 | = | 208.0 | nM | 328.27 | COc1c(O)cc2c(c1O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1OC2=O | Homo sapiens | CHEMBL4046839 | single protein format |
| CHEMBL3647448 |  |
IC50 | = | 291.0 | nM | 537.63 | Cc1ncc(NC(=O)c2ccc3c(c2)CC[C@@H]2C[C@@](O)(CCC(F)(F)F)CC[C@@]32Cc2ccccc2)c(C)n1 | Homo sapiens | CHEMBL3705674 | single protein format |
| CHEMBL5282465 |  |
IC50 | = | 560.0 | nM | 497.64 | CCOC(=O)C1=C(C)NC2S/C(=C\c3ccc(N4CCOCC4)cc3)C(=O)N2C1c1cccs1 | Homo sapiens | CHEMBL5231473 | single protein format |
| CHEMBL5289737 |  |
IC50 | = | 600.0 | nM | 547.68 | C=CCOc1ccc(C2C(C(=O)OCC)=C(C)NC3S/C(=C\c4ccc(N5CCOCC5)cc4)C(=O)N32)cc1 | Homo sapiens | CHEMBL5231473 | single protein format |
| CHEMBL2391027 |  |
IC50 | = | 860.0 | nM | 489.6 | CCOC(=O)C1=C(C)N=c2s/c(=C\c3ccc(N4CCOCC4)cc3)c(=O)n2C1c1ccccc1 | Homo sapiens | CHEMBL5231473 | single protein format |