P05198 | IF2A_HUMAN | Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00575 | S1 - S1 RNA binding domain | 14~88 | |
| PF07541 | EIF_2_alpha - Eukaryotic translation initiation factor 2 alpha subunit | 131~243 |
3D structures mapped by conservation among orthologs
[ Domain: "Nucleic acid-binding proteins" // S1_1 ]
[ Domain: "eIF2alpha middle domain" // EIF_2_alpha_N ]
[ Domain: "eIF-2-alpha, C-terminal domain" // EIF_2_alpha_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4857782 |  |
IC50 | = | 9.0 | nM | 468.5 | CCc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4858308 |  |
IC50 | = | 18.0 | nM | 446.55 | CCc1cccc([C@@H](O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4848143 |  |
IC50 | = | 23.0 | nM | 474.9 | CC(C)NC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2Cl)cnc1N | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4869882 |  |
IC50 | = | 27.0 | nM | 452.46 | Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC2CC2)c1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4862478 |  |
IC50 | = | 33.0 | nM | 454.48 | Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4853221 |  |
IC50 | = | 40.0 | nM | 452.94 | Cc1cc(NC(=O)[C@H](O)c2cccc(Cl)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4848359 |  |
IC50 | = | 40.0 | nM | 427.41 | CNC(=O)c1nc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2C)cnc1N | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4861671 |  |
IC50 | = | 42.0 | nM | 455.47 | Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)n1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4863698 |  |
IC50 | = | 45.0 | nM | 440.45 | CCNC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2C)cnc1N | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4870100 |  |
IC50 | = | 49.0 | nM | 455.46 | Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)OC(C)C)c1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4870780 |  |
IC50 | = | 54.0 | nM | 432.52 | Cc1cccc([C@@H](O)C(=O)Nc2ccc(-c3cnc(N)c(C(=O)NC(C)C)c3)c(C)c2)c1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4875875 |  |
IC50 | = | 58.0 | nM | 426.42 | CNC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2C)cnc1N | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4851480 |  |
IC50 | = | 72.0 | nM | 458.44 | CC(C)NC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2F)cnc1N | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4876496 |  |
IC50 | = | 114.0 | nM | 468.5 | Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)(C)C)c1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4854504 |  |
IC50 | = | 181.0 | nM | 439.46 | Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cncc(C(=O)NC(C)C)c1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4852735 |  |
IC50 | = | 187.0 | nM | 454.48 | Cc1cc(NC(=O)[C@@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4870495 |  |
IC50 | = | 198.0 | nM | 418.5 | Cc1cc(NC(=O)[C@H](O)c2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4866245 |  |
IC50 | = | 307.0 | nM | 402.5 | Cc1cc(NC(=O)Cc2ccccc2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4846663 |  |
IC50 | = | 313.0 | nM | 440.45 | CC(C)NC(=O)c1cc(-c2ccc(NC(=O)[C@H](O)c3cc(F)cc(F)c3)cc2)cnc1N | Homo sapiens | CHEMBL4822226 | single protein format |
| CHEMBL4870565 |  |
IC50 | = | 366.0 | nM | 470.48 | COc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(C(=O)NC(C)C)c1 | Homo sapiens | CHEMBL4822226 | single protein format |