P05186 | PPBT_HUMAN | Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00245 | Alk_phosphatase - Alkaline phosphatase | 51~490 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL461194 |  |
IC50 | = | 5.0 | nM | 334.59 | O=C(NCCO)c1cc(-c2ccc(Cl)c(Cl)c2Cl)n[nH]1 | Homo sapiens | CHEMBL1014656 | single protein format |
| CHEMBL1569928 |  |
IC50 | = | 6.0 | nM | 348.81 | COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2ccccc2c1 | Homo sapiens | CHEMBL4186501 | single protein format |
| CHEMBL4213116 |  |
IC50 | = | 23.0 | nM | 404.88 | COc1ccc(-c2cncc(NS(=O)(=O)c3cc(Cl)ccc3OC)c2)cc1 | Homo sapiens | CHEMBL4186501 | single protein format |
| CHEMBL4215759 |  |
IC50 | = | 26.0 | nM | 382.36 | COc1ccc(C(F)(F)F)cc1S(=O)(=O)Nc1cnc2ccccc2c1 | Homo sapiens | CHEMBL4186501 | single protein format |
| CHEMBL450981 |  |
IC50 | = | 31.0 | nM | 314.17 | O=C(NCCCO)c1cc(-c2ccc(Cl)cc2Cl)n[nH]1 | Homo sapiens | CHEMBL1014656 | single protein format |
| CHEMBL512931 |  |
IC50 | = | 35.0 | nM | 267.24 | O=C(NCCO)c1cc(-c2ccc(F)cc2F)n[nH]1 | Homo sapiens | CHEMBL1014656 | single protein format |
| CHEMBL466808 |  |
IC50 | = | 35.0 | nM | 328.2 | O=C(NCCCCO)c1cc(-c2ccc(Cl)cc2Cl)n[nH]1 | Homo sapiens | CHEMBL1014656 | single protein format |
| CHEMBL4216295 |  |
IC50 | = | 38.0 | nM | 339.38 | COc1ccc(C#N)cc1S(=O)(=O)Nc1cnc2ccccc2c1 | Homo sapiens | CHEMBL4186501 | single protein format |
| CHEMBL467854 |  |
IC50 | = | 44.0 | nM | 271.11 | NNC(=O)c1cc(-c2ccc(Cl)cc2Cl)n[nH]1 | Homo sapiens | CHEMBL1014656 | single protein format |
| CHEMBL467008 |  |
IC50 | = | 44.0 | nM | 300.15 | O=C(NCCO)c1cc(-c2ccc(Cl)cc2Cl)n[nH]1 | Homo sapiens | CHEMBL1014656 | single protein format |
| CHEMBL466809 |  |
IC50 | = | 46.0 | nM | 314.17 | COCCNC(=O)c1cc(-c2ccc(Cl)cc2Cl)n[nH]1 | Homo sapiens | CHEMBL1014656 | single protein format |
| CHEMBL459706 |  |
IC50 | = | 47.0 | nM | 344.2 | O=C(c1cc(-c2ccc(Cl)cc2Cl)n[nH]1)N(CCO)CCO | Homo sapiens | CHEMBL1014656 | single protein format |
| CHEMBL445965 |  |
IC50 | = | 51.0 | nM | 298.17 | CC(C)NC(=O)c1cc(-c2ccc(Cl)cc2Cl)n[nH]1 | Homo sapiens | CHEMBL1014656 | single protein format |
| CHEMBL511689 |  |
IC50 | = | 56.0 | nM | 332.16 | O=C(NCCCO)c1cc(-c2cc(F)c(Cl)cc2Cl)n[nH]1 | Homo sapiens | CHEMBL1014656 | single protein format |
| CHEMBL4206067 |  |
IC50 | = | 65.0 | nM | 356.79 | COC(=O)c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC)c1 | Homo sapiens | CHEMBL4186501 | single protein format |
| CHEMBL4217814 |  |
IC50 | = | 73.0 | nM | 375.84 | COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(-c2cccnc2)c1 | Homo sapiens | CHEMBL4186501 | single protein format |
| CHEMBL4214312 |  |
IC50 | = | 73.0 | nM | 371.42 | COc1ccc(OC)c(S(=O)(=O)Nc2cncc(-c3ccncc3)c2)c1 | Homo sapiens | CHEMBL4186501 | single protein format |
| CHEMBL4216888 |  |
IC50 | = | 73.0 | nM | 375.84 | COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(-c2ccncc2)c1 | Homo sapiens | CHEMBL4186501 | single protein format |
| CHEMBL459707 |  |
IC50 | = | 82.0 | nM | 312.2 | CC(C)CNC(=O)c1cc(-c2ccc(Cl)cc2Cl)n[nH]1 | Homo sapiens | CHEMBL1014656 | single protein format |
| CHEMBL501296 |  |
IC50 | = | 100.0 | nM | 318.14 | O=C(NCCO)c1cc(-c2cc(F)c(Cl)cc2Cl)n[nH]1 | Homo sapiens | CHEMBL1014656 | single protein format |