P05177 | CP1A2_HUMAN | Cytochrome P450 1A2 (CYP1A2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00067 | p450 - Cytochrome P450 | 42~493 |
3D structures mapped by conservation among orthologs
[ Domain: "Cytochrome P450" // p450 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4447260 |  |
IC50 | = | 1.5 | nM | 326.42 | COc1cc(/C=C/c2cccs2)cc(OCCn2ccnc2)c1 | Homo sapiens | CHEMBL4330009 | cell membrane format |
| CHEMBL42428 |  |
IC50 | = | 11.0 | nM | 246.33 | COc1cc(/C=C/c2cccs2)cc(OC)c1 | Homo sapiens | CHEMBL4330009 | cell membrane format |
| CHEMBL3645217 |  |
IC50 | = | 14.0 | nM | 427.46 | O=C(O)CCC(=O)Nc1ccc(-c2c(O)ccc3cc(-c4cccc(O)c4)ccc23)cc1 | Homo sapiens | CHEMBL3705052 | single protein format |
| CHEMBL45245 |  |
IC50 | = | 16.0 | nM | 195.22 | O=c1[nH]c2ccccc2c2ccccc12 | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL828 |  |
IC50 | = | 16.0 | nM | 199.28 | c1ccc2c(c1)Nc1ccccc1S2 | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL311469 |  |
IC50 | = | 16.0 | nM | 223.27 | CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2 | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL31184 |  |
IC50 | = | 40.0 | nM | 252.32 | c1ccc2c(c1)cc1ccc3cccc4ccc2c1c34 | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL416 |  |
IC50 | = | 40.0 | nM | 216.19 | COc1c2occc2cc2ccc(=O)oc12 | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL1371125 |  |
IC50 | = | 100.0 | nM | 252.32 | c1ccc2c(c1)c1cccc3ccc4cccc2c4c31 | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL506 |  |
IC50 | = | 182.4 | nM | 259.35 | COc1cc(NC(C)CCCN)c2ncccc2c1 | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL14192 |  |
IC50 | = | 200.0 | nM | 158.2 | c1ccc(Cn2ccnc2)cc1 | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL1650646 |  |
IC50 | = | 259.0 | nM | 343.38 | COc1ccc(-c2c(O)ccc3cc(-c4cccc(O)c4)ccc23)cn1 | Homo sapiens | CHEMBL3705052 | single protein format |
| CHEMBL808 |  |
IC50 | = | 300.0 | nM | 381.69 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL193 |  |
IC50 | = | 300.0 | nM | 346.34 | COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL40583 |  |
IC50 | = | 300.0 | nM | 268.36 | Cc1ccc2cc3c(ccc4ccccc43)c3c2c1CC3 | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL3939800 |  |
IC50 | < | 310.0 | nM | 349.37 | Cc1cc(Nc2nc([C@@H](O)c3ccc(F)cc3)nc3ccccc23)n[nH]1 | Homo sapiens | CHEMBL3888162 | tissue-based format |
| CHEMBL3545241 |  |
IC50 | < | 310.0 | nM | 349.37 | Cc1cc(Nc2nc(C(O)c3ccc(F)cc3)nc3ccccc23)n[nH]1 | Homo sapiens | CHEMBL3888162 | tissue-based format |
| CHEMBL60889 |  |
IC50 | = | 400.0 | nM | 421.9 | CCOc1cc(N)c(Cl)cc1C(=O)NCC1CN(Cc2ccc(F)cc2)CCO1 | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL960 |  |
IC50 | = | 500.0 | nM | 270.21 | Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL1909132 | cell-based format |
| CHEMBL5207531 |  |
IC50 | = | 560.0 | nM | 417.29 | COc1ccc(OCc2nn3c(-c4ccc(Br)cc4)nnc3s2)cc1 | Homo sapiens | CHEMBL5139676 | microsome format |