P05164 | PERM_HUMAN | Myeloperoxidase (MPO)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03098 | An_peroxidase - Animal haem peroxidase | 173~717 |
3D structures mapped by conservation among orthologs
[ Domain: "Heme-dependent peroxidases" // An_peroxidase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4747269 |  |
IC50 | = | 1.0 | nM | 460.59 | Nc1cc([C@H](CCN[C@H]2C[C@@H](c3ccccc3)c3ccccc32)c2ccccc2)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4703118 | single protein format |
| CHEMBL4790231 |  |
IC50 | = | 1.4 | nM | 452.61 | Nc1cc([C@H](CCNC23CCC(c4ccccc4)(CC2)CC3)c2ccccc2)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4703118 | single protein format |
| CHEMBL5095218 |  |
IC50 | = | 1.5 | nM | 334.83 | C[C@@H](N)c1cc(Cl)ccc1Cn1c(=S)[nH]c(=O)c2[nH]ccc21 | Homo sapiens | CHEMBL5130499 | single protein format |
| CHEMBL4763667 |  |
IC50 | = | 2.0 | nM | 426.57 | Nc1cc([C@H](CCN[C@H]2CC[C@H](c3ccccc3)CC2)c2ccccc2)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4703118 | single protein format |
| CHEMBL4752248 |  |
IC50 | = | 2.9 | nM | 474.61 | Nc1cc([C@H](CCN[C@@H]2CC[C@@H](c3ccccc3)c3ccccc32)c2ccccc2)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4703118 | single protein format |
| CHEMBL5181350 |  |
IC50 | = | 3.6 | nM | 335.82 | C[C@@H](N)c1cc(Cl)ccc1Cn1c(=S)[nH]c(=O)c2[nH]cnc21 | Homo sapiens | CHEMBL5130499 | single protein format |
| CHEMBL4548537 |  |
IC50 | = | 4.6 | nM | 326.21 | Nc1cc(SCc2c(Cl)cccc2Cl)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4329744 | assay format |
| CHEMBL5197968 |  |
IC50 | = | 5.0 | nM | 362.46 | NC(c1ccccc1)c1ccccc1Cn1c(=S)[nH]c(=O)c2[nH]ccc21 | Homo sapiens | CHEMBL5130499 | single protein format |
| CHEMBL4068067 |  |
IC50 | = | 5.0 | nM | 396.25 | O=C(NO)c1c[nH]c(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)nc1=O | Homo sapiens | CHEMBL4013915 | single protein format |
| CHEMBL4740830 |  |
IC50 | = | 5.0 | nM | 498.65 | Nc1cc([C@H](CCN(CCF)C23CCC(c4ccccc4)(CC2)CC3)c2ccccc2)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4703118 | single protein format |
| CHEMBL4861370 |  |
IC50 | = | 5.0 | nM | 520.64 | Nc1cc([C@H]2CCN[C@H]3C[C@H](Cc4ccccc4)[C@@H](C3)Oc3cccc(c3)Cn3cc2cn3)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4812316 | single protein format |
| CHEMBL2347170 |  |
IC50 | = | 6.0 | nM | 238.33 | NCCSCCc1c[nH]c2c(F)cccc12 | Homo sapiens | CHEMBL2352939 | single protein format |
| CHEMBL4782307 |  |
IC50 | = | 6.0 | nM | 466.63 | CN(CC[C@H](c1ccccc1)c1cc(N)nc2[nH]nnc12)C12CCC(c3ccccc3)(CC1)CC2 | Homo sapiens | CHEMBL4703118 | single protein format |
| CHEMBL4453728 |  |
IC50 | = | 6.7 | nM | 310.14 | Nc1cc(OCc2c(Cl)cccc2Cl)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4329744 | assay format |
| CHEMBL4851535 |  |
IC50 | = | 7.0 | nM | 546.68 | Nc1cc(C2CCNC34CCC(c5ccccc5)(CC3)[C@H](C4)Oc3cccc(c3)Cn3cc2cn3)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4812316 | single protein format |
| CHEMBL2347168 |  |
IC50 | = | 8.0 | nM | 238.33 | NCCSCCc1c[nH]c2ccc(F)cc12 | Homo sapiens | CHEMBL2352939 | single protein format |
| CHEMBL1630742 |  |
IC50 | = | 8.0 | nM | 220.29 | NCCCCCc1c[nH]c2ccc(F)cc12 | Homo sapiens | CHEMBL1640945 | tissue-based format |
| CHEMBL4878307 |  |
IC50 | = | 8.0 | nM | 466.55 | Nc1cc(C2CCNCc3cccc(c3)OCc3cccc(c3)Cn3cc2cn3)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4812316 | single protein format |
| CHEMBL4594116 |  |
IC50 | = | 8.5 | nM | 374.38 | Nc1cc(SCc2nn(-c3ccccc3)nc2C(F)F)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4329744 | assay format |
| CHEMBL4482878 |  |
IC50 | = | 8.7 | nM | 275.31 | Nc1cc(SCc2ccccc2F)c2nn[nH]c2n1 | Homo sapiens | CHEMBL4329744 | assay format |