P05129 | KPCG_HUMAN | Protein kinase C gamma type (PRKCG)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 353~599 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 36~86 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 101~152 | |
| PF00168 | C2 - C2 domain | 173~277 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 642~675 |
3D structures mapped by conservation among orthologs
[ Domain: "C2 domain" // C2_2 ]
[ Domain: "Cysteine-rich domain" // C1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL302449 |  |
IC50 | = | 2.0 | nM | 378.44 | Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O | Homo sapiens | CHEMBL939361 | single protein format |
| CHEMBL432168 |  |
IC50 | = | 5.0 | nM | 536.49 | N[C@@H]1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 | Homo sapiens | CHEMBL767890 | single protein format |
| CHEMBL75661 |  |
IC50 | = | 5.0 | nM | 551.5 | O=C(N[C@@H]1C[C@H](CO)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL767890 | single protein format |
| CHEMBL300422 |  |
IC50 | = | 5.0 | nM | 493.47 | O=C(OC1CNCC1Cc1ccc(O)cc1)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 | Homo sapiens | CHEMBL767412 | single protein format |
| CHEMBL421866 |  |
IC50 | = | 5.0 | nM | 550.52 | NC[C@H]1C[C@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 | Homo sapiens | CHEMBL772955 | single protein format |
| CHEMBL417051 |  |
IC50 | = | 5.0 | nM | 536.49 | N[C@@H]1C[C@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 | Homo sapiens | CHEMBL772955 | single protein format |
| CHEMBL306427 |  |
IC50 | = | 5.0 | nM | 551.5 | O=C(N[C@H]1C[C@H](CO)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL772955 | single protein format |
| CHEMBL307708 |  |
IC50 | = | 5.0 | nM | 550.52 | NC[C@H]1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 | Homo sapiens | CHEMBL767890 | single protein format |
| CHEMBL308263 |  |
IC50 | = | 10.0 | nM | 550.52 | NC[C@@H]1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 | Homo sapiens | CHEMBL767890 | single protein format |
| CHEMBL71331 |  |
IC50 | = | 10.0 | nM | 521.48 | O=C(NC1CCC[C@@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL767891 | single protein format |
| CHEMBL48636 |  |
IC50 | = | 10.0 | nM | 521.48 | O=C(NC1CCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL767412 | single protein format |
| CHEMBL427118 |  |
IC50 | = | 10.0 | nM | 521.48 | O=C(N[C@@H]1CCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL758470 | single protein format |
| CHEMBL67290 |  |
IC50 | = | 10.0 | nM | 550.52 | NC[C@@H]1C[C@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 | Homo sapiens | CHEMBL772955 | single protein format |
| CHEMBL52529 |  |
IC50 | = | 10.0 | nM | 521.48 | O=C(N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL772956 | single protein format |
| CHEMBL177635 |  |
IC50 | = | 12.0 | nM | 522.47 | O=C(N[C@@H]1CNCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL758470 | single protein format |
| CHEMBL265559 |  |
IC50 | = | 12.0 | nM | 522.47 | O=C(NC1CNCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL761877 | single protein format |
| CHEMBL59828 |  |
IC50 | = | 13.0 | nM | 522.47 | O=C(N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL772956 | single protein format |
| CHEMBL422056 |  |
IC50 | = | 14.0 | nM | 522.47 | O=C(NC1CNC[C@@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL767891 | single protein format |
| CHEMBL306580 |  |
IC50 | = | 20.0 | nM | 537.48 | O=C(N[C@@H]1CC(O)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL767890 | single protein format |
| CHEMBL67716 |  |
IC50 | = | 30.0 | nM | 537.48 | O=C(N[C@H]1C[C@H](O)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL772955 | single protein format |