P05121 | PAI1_HUMAN | Plasminogen activator inhibitor 1 (SERPINE1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00079 | Serpin - Serpin (serine protease inhibitor) | 35~402 |
3D structures mapped by conservation among orthologs
[ Domain: "Serpins" // Serpin ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3669191 |  |
IC50 | = | 50.0 | nM | 420.37 | O=C(O[C@H]1CC[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)CC1)c1cc(O)c(O)c(O)c1 | Homo sapiens | CHEMBL3705870 | single protein format |
| CHEMBL3669189 |  |
IC50 | = | 50.0 | nM | 420.37 | O=C(O[C@@H]1CCC[C@H](OC(=O)c2cc(O)c(O)c(O)c2)C1)c1cc(O)c(O)c(O)c1 | Homo sapiens | CHEMBL3705870 | single protein format |
| CHEMBL3669200 |  |
IC50 | = | 70.0 | nM | 495.44 | CC(C)(C)OC(=O)NCC(COC(=O)c1cc(O)c(O)c(O)c1)OC(=O)c1cc(O)c(O)c(O)c1 | Homo sapiens | CHEMBL3705870 | single protein format |
| CHEMBL3669193 |  |
IC50 | = | 90.0 | nM | 376.37 | O=S(=O)(NNS(=O)(=O)c1ccc(O)c(O)c1)c1ccc(O)c(O)c1 | Homo sapiens | CHEMBL3705870 | single protein format |
| CHEMBL87654 |  |
IC50 | = | 200.0 | nM | 573.67 | O=C(O)CCCCCCCOc1ccc(/C=c2\[nH]c(=O)/c(=C/c3ccc(NC(=O)c4cccs4)cc3)[nH]c2=O)cc1 | Homo sapiens | CHEMBL766350 | single protein format |
| CHEMBL2087115 |  |
IC50 | = | 280.0 | nM | 420.37 | O=C(O[C@H]1CCCC[C@H]1OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1 | Homo sapiens | CHEMBL3705870 | single protein format |
| CHEMBL596879 |  |
IC50 | = | 284.0 | nM | 445.52 | CCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1 | Homo sapiens | CHEMBL1072391 | single protein format |
| CHEMBL10004 |  |
IC50 | = | 290.0 | nM | 594.7 | O=C(Nc1ccc(OCCCCCCCn2cnnn2)cc1)c1c(O)nc2ccc(-c3cc4ccccc4s3)cc2c1O | Homo sapiens | CHEMBL847120 | single protein format |
| CHEMBL77246 |  |
IC50 | = | 300.0 | nM | 426.48 | O=c1[nH]/c(=C\c2ccccn2)c(=O)[nH]/c1=C\c1ccc(OCCCc2cccnc2)cc1 | Homo sapiens | CHEMBL766349 | single protein format |
| CHEMBL10181 |  |
IC50 | = | 300.0 | nM | 570.67 | O=C(O)CCCCCCCOc1ccc(NC(=O)c2c(O)nc3cc(-c4cc5ccccc5s4)ccc3c2O)cc1 | Homo sapiens | CHEMBL847119 | single protein format |
| CHEMBL2087114 |  |
IC50 | = | 370.0 | nM | 366.28 | O=C(OCCOC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1 | Homo sapiens | CHEMBL3705870 | single protein format |
| CHEMBL419935 |  |
IC50 | = | 380.0 | nM | 470.52 | CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OCC(=O)Nc1cc(Oc2ccc(C(=O)O)cc2)ccc1[N+](=O)[O-] | Homo sapiens | CHEMBL759845 | single protein format |
| CHEMBL114144 |  |
IC50 | = | 400.0 | nM | 470.52 | CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OCC(=O)Nc1cc(Oc2cccc(C(=O)O)c2)ccc1[N+](=O)[O-] | Homo sapiens | CHEMBL766346 | single protein format |
| CHEMBL10014 |  |
IC50 | = | 500.0 | nM | 570.67 | O=C(O)CCCCCCCOc1ccc(NC(=O)c2c(O)nc3ccc(-c4cc5ccccc5s4)cc3c2O)cc1 | Homo sapiens | CHEMBL847119 | single protein format |
| CHEMBL111847 |  |
IC50 | = | 500.0 | nM | 575.71 | COc1cccc(CNc2ccc(CNC(=O)CO[C@@H]3C[C@H](C)CC[C@H]3C(C)C)cc2)c1Oc1ncccc1C(=O)O | Homo sapiens | CHEMBL766346 | single protein format |
| CHEMBL10062 |  |
IC50 | = | 510.0 | nM | 573.67 | O=C(O)CCCCCCCOc1ccc(/C=c2/[nH]c(=O)/c(=C/c3ccc(NC(=O)c4cccs4)cc3)[nH]c2=O)cc1 | Homo sapiens | CHEMBL847120 | single protein format |
| CHEMBL10240 |  |
IC50 | = | 510.0 | nM | 570.67 | O=C(O)CCCCCCCOc1ccc(NC(=O)c2c(O)nc3ccc(-c4csc5ccccc45)cc3c2O)cc1 | Homo sapiens | CHEMBL847119 | single protein format |
| CHEMBL86470 |  |
IC50 | = | 520.0 | nM | 586.67 | O=C(O)CCCCCCC(=O)Nc1ccc(/C=c2\[nH]c(=O)/c(=C/c3ccc(NC(=O)c4cccs4)cc3)[nH]c2=O)cc1 | Homo sapiens | CHEMBL766350 | single protein format |
| CHEMBL601265 |  |
IC50 | = | 594.0 | nM | 443.5 | O=S(=O)(c1ccc(O)c(O)c1)N(C1CCCCC1)S(=O)(=O)c1ccc(O)c(O)c1 | Homo sapiens | CHEMBL1072391 | single protein format |
| CHEMBL311452 |  |
IC50 | = | 600.0 | nM | 432.51 | O=c1[nH]/c(=C\c2nccs2)c(=O)[nH]/c1=C\c1ccc(OCCCc2cccnc2)cc1 | Homo sapiens | CHEMBL766349 | single protein format |