P05089 | ARGI1_HUMAN | Arginase-1 (ARG1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00491 | Arginase - Arginase family | 7~301 |
3D structures mapped by conservation among orthologs
[ Domain: "Arginase/deacetylase" // Arginase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4764455 |  |
IC50 | = | 0.1 | nM | 338.2 | NCCNS(=O)(=O)N1C[C@H](CCCB(O)O)[C@](N)(C(=O)O)C1 | Homo sapiens | CHEMBL4729732 | single protein format |
| CHEMBL4754637 |  |
IC50 | = | 0.8 | nM | 341.22 | N[C@H](C(=O)N[C@H]1CN[C@H](C(=O)O)[C@@H]1CCCB(O)O)C1CCCC1 | Homo sapiens | CHEMBL4729729 | single protein format |
| CHEMBL4748950 |  |
IC50 | = | 0.8 | nM | 329.21 | CC(C)(C)[C@H](N)C(=O)N[C@H]1CN[C@H](C(=O)O)[C@@H]1CCCB(O)O | Homo sapiens | CHEMBL4729729 | single protein format |
| CHEMBL4750602 |  |
IC50 | = | 1.0 | nM | 367.22 | C[C@@H]1N(C(=O)[C@@H](N)Cc2c[nH]cn2)C[C@@H](CCB(O)O)C[C@]1(N)C(=O)O | Homo sapiens | CHEMBL4729732 | single protein format |
| CHEMBL5170454 |  |
IC50 | = | 1.0 | nM | 375.3 | CSCC[C@H](N)C(=O)NC[C@@H]1CC[C@@H](CCB(O)O)C[C@]1(N)C(=O)O | Homo sapiens | CHEMBL5130940 | assay format |
| CHEMBL5171566 |  |
IC50 | = | 1.0 | nM | 357.26 | CC(C)C[C@H](N)C(=O)NC[C@@H]1CC[C@@H](CCB(O)O)C[C@]1(N)C(=O)O | Homo sapiens | CHEMBL5130940 | assay format |
| CHEMBL5176739 |  |
IC50 | = | 1.0 | nM | 301.15 | NCC(=O)NC[C@@H]1CC[C@@H](CCB(O)O)C[C@]1(N)C(=O)O | Homo sapiens | CHEMBL5130940 | assay format |
| CHEMBL5184299 |  |
IC50 | = | 1.0 | nM | 343.23 | CC(C)[C@@H](N)C(=O)NC[C@@H]1CC[C@@H](CCB(O)O)C[C@]1(N)C(=O)O | Homo sapiens | CHEMBL5130940 | assay format |
| CHEMBL5193387 |  |
IC50 | = | 1.0 | nM | 315.18 | C[C@@H](N)C(=O)NC[C@@H]1CC[C@@H](CCB(O)O)C[C@]1(N)C(=O)O | Homo sapiens | CHEMBL5130940 | assay format |
| CHEMBL4755855 |  |
IC50 | = | 1.0 | nM | 287.12 | C[C@@H]1N(C(=O)CN)C[C@@H](CCB(O)O)C[C@]1(N)C(=O)O | Homo sapiens | CHEMBL4729732 | single protein format |
| CHEMBL4793482 |  |
IC50 | = | 1.0 | nM | 312.22 | N[C@]1(C(=O)O)C[C@H](CCB(O)O)CC[C@H]1CN1CCCCC1 | Homo sapiens | CHEMBL4729732 | single protein format |
| CHEMBL4749434 |  |
IC50 | = | 1.0 | nM | 301.15 | C[C@H](N)C(=O)N1C[C@@H](CCB(O)O)C[C@](N)(C(=O)O)[C@@H]1C | Homo sapiens | CHEMBL4729732 | single protein format |
| CHEMBL4538713 |  |
IC50 | = | 1.3 | nM | 349.24 | N[C@@H](Cc1ccccc1)CN1C[C@H](CCCB(O)O)[C@](N)(C(=O)O)C1 | Homo sapiens | CHEMBL4337249 | assay format |
| CHEMBL4871970 |  |
IC50 | = | 1.6 | nM | 242.08 | O=C(O)[C@H]1NC[C@@H]2NCC[C@@]21CCCB(O)O | Homo sapiens | CHEMBL4845551 | single protein format |
| CHEMBL4791224 |  |
IC50 | = | 1.6 | nM | 329.21 | CC(C)C[C@H](N)C(=O)N[C@H]1CN[C@H](C(=O)O)[C@@H]1CCCB(O)O | Homo sapiens | CHEMBL4729729 | single protein format |
| CHEMBL4850213 |  |
IC50 | = | 2.0 | nM | 315.18 | CC(C)[C@H](N)C(=O)N[C@H]1CN[C@H](C(=O)O)[C@@H]1CCCB(O)O | Homo sapiens | CHEMBL4839698 | assay format |
| CHEMBL4873520 |  |
IC50 | = | 2.2 | nM | 242.08 | O=C(O)[C@]12CCN[C@H](CN1)[C@@H]2CCCB(O)O | Homo sapiens | CHEMBL4845551 | single protein format |
| CHEMBL4450972 |  |
IC50 | = | 2.5 | nM | 335.21 | N[C@H](CN1C[C@H](CCCB(O)O)[C@](N)(C(=O)O)C1)c1ccccc1 | Homo sapiens | CHEMBL4337249 | assay format |
| CHEMBL4557975 |  |
IC50 | = | 2.6 | nM | 313.21 | N[C@@]1(C(=O)O)CN(C[C@H]2CCCCN2)C[C@@H]1CCCB(O)O | Homo sapiens | CHEMBL4337249 | assay format |
| CHEMBL4749355 |  |
IC50 | = | 3.0 | nM | 244.1 | CN[C@H]1CN[C@@](CCCCB(O)O)(C(=O)O)C1 | Homo sapiens | CHEMBL4729729 | single protein format |