3D structures mapped by conservation among orthologs

[ Domain: "Common fold of diphtheria toxin/transcription factors/cytochrome f" // P53 ]

 PyMOL session

[ Domain: "p53 tetramerization domain" // P53_tetramer ]

 PyMOL session

[ Domain: "p53 transactivation domain" // EUF08766 ]

 PyMOL session

[ Domain: "p53 transactivation domain" // P53_TAD ]

 PyMOL session

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

 IC50 CSV

Only the first 20 rows are shown.

molecule_chembl_id	structure	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL2059435		IC50	=	760.0	nM	478.42	CC[C@@H]([C@H](C)O)N1C(=O)[C@@](C)(CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1	Homo sapiens	CHEMBL2182644	cell-based format
CHEMBL191334		IC50	=	1000.0	nM	581.5	COc1ccc(C2=N[C@@H](c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1	Homo sapiens	CHEMBL1052166	cell-based format
CHEMBL583413		IC50	=	1000.0	nM	564.28	Cc1ccc2c(c1)C1=C(C(c3ccc(Br)cc3)O2)C(c2ccc(Br)cc2)n2ncnc2N1C	Homo sapiens	CHEMBL1052166	cell-based format
CHEMBL2059300		IC50	=	1000.0	nM	534.48	CC[C@@H](C(=O)OC(C)(C)C)N1C(=O)[C@@](C)(CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1	Homo sapiens	CHEMBL2182648	cell-based format