P04629 | NTRK1_HUMAN | High affinity nerve growth factor receptor (NTRK1)

Pfam Domain Table

AccessionDomainRangeColor
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase512~781
PF13855LRR_8 - Leucine rich repeat92~150
PF16920LRRCT_2 - Leucine rich repeat C-terminal motif151~192
PF18613TrkA_TMD - Tyrosine kinase receptor A trans-membrane domain417~438

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_10 ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_11 ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_11 ]

 PyMOL session

[ Domain: "Leucine-rich repeats" // LRR_8_1 ]

 PyMOL session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session

[ Domain: "Transmembrane segment of lysosome-associated membrane glycoprotein 2" // EUF08790 ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4562879 IC50 = 0.1 nM 354.36 Cc1cc(-c2cnc3ccc(N[C@@H](C)c4ccc(F)cc4F)nn23)[nH]n1 Homo sapiens CHEMBL4397146 assay format
CHEMBL5170464 IC50 = 0.1 nM 368.39 CCn1cc(-c2cnn3ccc(N[C@H](C)c4cc(F)ccc4F)nc23)cn1 Homo sapiens CHEMBL5110448 single protein format
CHEMBL5189971 IC50 = 0.1 nM 394.43 C[C@@H](Nc1ccn2ncc(-c3cnn(C4CCC4)c3)c2n1)c1cc(F)ccc1F Homo sapiens CHEMBL5110448 single protein format
CHEMBL5170096 IC50 = 0.1 nM 390.34 C[C@@H](Nc1ccn2ncc(-c3cnn(C(F)F)c3)c2n1)c1cc(F)ccc1F Homo sapiens CHEMBL5110448 single protein format
CHEMBL4518176 IC50 = 0.16 nM 538.51 Cn1ccc(-c2cc(C(=O)Nc3c4ncc(C(C)(C)O)cc4nn3-c3ccccc3)c(F)cc2C(F)(F)F)n1 Homo sapiens CHEMBL4349459 cell-based format
CHEMBL4449648 IC50 = 0.2 nM 401.42 CC(C)N1Cc2cc(c(F)cc2F)OCCCNC(=O)c2cnn3ccc1nc23 Homo sapiens CHEMBL4349459 cell-based format
CHEMBL4462919 IC50 = 0.2 nM 396.45 CS(=O)(=O)c1ccc(F)cc1CNc1ccc2[nH]nc(-c3cccnc3)c2c1 Homo sapiens CHEMBL4349732 assay format
CHEMBL4555442 IC50 = 0.2 nM 399.45 Cn1cc(-c2n[nH]c3ccc(NCc4cc(F)ccc4S(C)(=O)=O)cc23)cn1 Homo sapiens CHEMBL4349732 assay format
CHEMBL3678287 IC50 = 0.2 nM 515.52 COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1csc(C(F)(F)F)n1 Homo sapiens CHEMBL3887112 single protein format
CHEMBL3678286 IC50 = 0.2 nM 522.53 COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(CC(F)(F)F)cc1 Homo sapiens CHEMBL3887112 single protein format
CHEMBL3678285 IC50 = 0.2 nM 483.58 COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(C)C)nc1 Homo sapiens CHEMBL3887112 single protein format
CHEMBL3678284 IC50 = 0.2 nM 540.57 COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(SC(F)(F)F)cc1 Homo sapiens CHEMBL3887112 single protein format
CHEMBL3678283 IC50 = 0.2 nM 524.5 COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(OC(F)(F)F)cc1 Homo sapiens CHEMBL3887112 single protein format
CHEMBL3673478 IC50 = 0.2 nM 508.5 COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(F)(F)F)cc1 Homo sapiens CHEMBL3887112 single protein format
CHEMBL3676026 IC50 = 0.2 nM 400.41 COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NCCO)c2n1 Homo sapiens CHEMBL3887070 single protein format
CHEMBL3673479 IC50 = 0.2 nM 481.56 COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C2CC2)nc1 Homo sapiens CHEMBL3887112 single protein format
CHEMBL4554856 IC50 = 0.2 nM 417.87 CC(C)N1Cc2cc(cc(F)c2Cl)O[C@@H](C)CNC(=O)c2cnn3cc1cnc23 Homo sapiens CHEMBL4349459 cell-based format
CHEMBL5200318 IC50 = 0.2 nM 366.38 Fc1ccc(F)c([C@H]2CCCN2c2ccn3ncc(-c4cn[nH]c4)c3n2)c1 Homo sapiens CHEMBL5123462 cell-based format
CHEMBL3673477 IC50 = 0.2 nM 509.49 COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(F)(F)F)nc1 Homo sapiens CHEMBL3887112 single protein format
CHEMBL4562203 IC50 = 0.25 nM 524.48 CC(O)c1cnc2c(NC(=O)c3cc(-c4ccn(C)n4)c(C(F)(F)F)cc3F)n(-c3ccccc3)nc2c1 Homo sapiens CHEMBL4349459 cell-based format