P04626 | ERBB2_HUMAN | Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00757 | Furin-like - Furin-like cysteine rich region | 190~343 | |
| PF01030 | Recep_L_domain - Receptor L domain | 52~172 | |
| PF01030 | Recep_L_domain - Receptor L domain | 366~484 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 722~975 | |
| PF14843 | GF_recep_IV - Growth factor receptor domain IV | 511~642 | |
| PF21314 | TM_ErbB1 - Epidermal growth factor receptor transmembrane-juxtamembrane segment | 654~688 |
3D structures mapped by conservation among orthologs
[ Domain: "Leucine-rich repeats" // Recep_L_domain ]
[ Domain: "Leucine-rich repeats" // GF_recep_IV,Recep_L_domain ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "Growth factor receptor domain" // GF_recep_IV ]
[ Domain: "Growth factor receptor domain" // Furin-like ]
[ Domain: "Epidermal growth factor receptor transmembrane-juxtamembrane segment" // TM_ErbB1 ]
[ Domain: "Epidermal growth factor receptor transmembrane-juxtamembrane segment" // KOG1025 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL941 |  |
IC50 | = | 0.06 | nM | 493.62 | Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 | Homo sapiens | CHEMBL5216307 | single protein format |
| CHEMBL5221067 |  |
IC50 | = | 0.14 | nM | 352.42 | N#Cc1c(NC(=O)CNc2n[nH]c3ncccc23)sc2c1CCCC2 | Homo sapiens | CHEMBL5216307 | single protein format |
| CHEMBL3344216 |  |
IC50 | = | 0.5 | nM | 595.1 | CN(C)[C@H](CS(C)(=O)=O)c1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1 | Homo sapiens | CHEMBL3385739 | single protein format |
| CHEMBL437890 |  |
IC50 | = | 0.5 | nM | 512.39 | CN1CCN(CCC#CC(=O)Nc2cc3c(Nc4ccc(F)c(Br)c4)ncnc3cn2)CC1 | Homo sapiens | CHEMBL862513 | assay format |
| CHEMBL204638 |  |
IC50 | = | 0.7 | nM | 499.34 | O=C(C#CCCN1CCOCC1)Nc1cc2c(Nc3ccc(F)c(Br)c3)ncnc2cn1 | Homo sapiens | CHEMBL862513 | assay format |
| CHEMBL203599 |  |
IC50 | = | 0.7 | nM | 467.94 | CN1CCN(CCC#CC(=O)Nc2cc3c(Nc4ccc(F)c(Cl)c4)ncnc3cn2)CC1 | Homo sapiens | CHEMBL862513 | assay format |
| CHEMBL203661 |  |
IC50 | = | 0.8 | nM | 454.89 | O=C(C#CCCN1CCOCC1)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1 | Homo sapiens | CHEMBL862513 | assay format |
| CHEMBL2048911 |  |
IC50 | = | 0.92 | nM | 570.51 | Cl.O=C(NCCn1ccc2ncnc(Nc3ccc(Oc4cccc5sncc45)c(Cl)c3)c21)[C@@H]1CCCN1 | Homo sapiens | CHEMBL2050648 | single protein format |
| CHEMBL5282641 |  |
IC50 | = | 0.96 | nM | 547.41 | C=CC(=O)N1CCC(Oc2cc3c(Nc4ccc(Cl)c(Cl)c4F)ncnc3cc2O[C@H]2CCOC2)CC1 | Homo sapiens | CHEMBL5255145 | single protein format |
| CHEMBL2048912 |  |
IC50 | = | 0.98 | nM | 522.03 | CC(C)(N)C(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc5sncc45)c(Cl)c3)c21 | Homo sapiens | CHEMBL2050648 | single protein format |
| CHEMBL258282 |  |
IC50 | = | 1.0 | nM | 494.99 | CN1CCN(CCOc2n[nH]c3ncnc(Nc4ccc(OCc5ccccn5)c(Cl)c4)c23)CC1 | Homo sapiens | CHEMBL947895 | single protein format |
| CHEMBL4075917 |  |
IC50 | = | 1.0 | nM | 454.51 | Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccc(F)cc3O)cc12 | Homo sapiens | CHEMBL4018643 | single protein format |
| CHEMBL4067871 |  |
IC50 | = | 1.0 | nM | 467.96 | OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3cnccc3c2)c1)c1ccccc1 | Homo sapiens | CHEMBL4018643 | single protein format |
| CHEMBL4105329 |  |
IC50 | = | 1.0 | nM | 470.96 | Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(Cl)ccc3O)cc12 | Homo sapiens | CHEMBL4018643 | single protein format |
| CHEMBL490062 |  |
IC50 | = | 1.0 | nM | 552.66 | CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc5c(cnn5Cc5ccccc5)c4)c3c2)o1 | Homo sapiens | CHEMBL953992 | single protein format |
| CHEMBL483332 |  |
IC50 | = | 1.0 | nM | 464.96 | C[C@H](CN(C)C)Oc1cccc2ncnc(Nc3ccc(OCc4cnccn4)c(Cl)c3)c12 | Homo sapiens | CHEMBL953992 | single protein format |
| CHEMBL3344210 |  |
IC50 | = | 1.0 | nM | 581.07 | CNC(CS(C)(=O)=O)c1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1 | Homo sapiens | CHEMBL3385739 | single protein format |
| CHEMBL271705 |  |
IC50 | < | 1.0 | nM | 481.94 | Clc1cc(Nc2ncnc3[nH]nc(OCCN4CCOCC4)c23)ccc1OCc1ccccn1 | Homo sapiens | CHEMBL947895 | single protein format |
| CHEMBL5176920 |  |
IC50 | = | 1.06 | nM | 536.6 | Cc1cc(Nc2ncnc3cc(O)c(NC(=O)/C=C/[C@H]4CCCN4C)cc23)ccc1Oc1cc2nccn2cn1 | Homo sapiens | CHEMBL5162302 | cell-based format |
| CHEMBL203644 |  |
IC50 | = | 1.1 | nM | 355.76 | CC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1 | Homo sapiens | CHEMBL862513 | assay format |