P04183 | KITH_HUMAN | Thymidine kinase, cytosolic (TK1)

Pfam Domain Table

AccessionDomainRangeColor
PF00265TK - Thymidine kinase19~189

3D structures mapped by conservation among orthologs

[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // TK_N ]

 PyMOL session

[ Domain: "LIM domain-like" // TK_C ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL132598 IC50 = 2.0 nM 488.59 Cc1cn(Cc2ccccc2COC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]c1=O Homo sapiens CHEMBL814781 cell-based format
CHEMBL52609 IC50 = 26.0 nM 242.23 Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O Homo sapiens CHEMBL814146 cell-based format
CHEMBL101135 IC50 = 180.0 nM 438.53 Cc1cn(C/C=C\COC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]c1=O Homo sapiens CHEMBL814781 cell-based format
CHEMBL422810 IC50 = 230.0 nM 438.53 Cc1cn(C/C=C/COC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]c1=O Homo sapiens CHEMBL814781 cell-based format
CHEMBL406254 Ki = 50.0 nM 299.33 O=c1[nH]c(Nc2ccccc2)nc2c1ncn2CCCCO Homo sapiens CHEMBL816091 single protein format
CHEMBL788 Ki = 90.0 nM 354.1 O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1I Homo sapiens CHEMBL816084 single protein format
CHEMBL1269499 Ki = 90.0 nM 274.25 CCc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2F)c(=O)[nH]c1=O Homo sapiens CHEMBL810054 single protein format
CHEMBL31634 Ki = 100.0 nM 333.14 O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1/C=C/Br Homo sapiens CHEMBL816084 single protein format
CHEMBL271475 Ki = 140.0 nM 372.09 O=c1[nH]c(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2F)cc1I Homo sapiens CHEMBL810054 single protein format
CHEMBL475717 Ki = 180.0 nM 260.22 Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2F)c(=O)[nH]c1=O Homo sapiens CHEMBL810054 single protein format
CHEMBL52609 Ki = 200.0 nM 242.23 Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O Homo sapiens CHEMBL816084 single protein format
CHEMBL2311131 Ki = 210.0 nM 352.13 O=c1[nH]c(=O)n([C@@H]2C[C@H](CO)[C@@H](O)C2)cc1I Homo sapiens CHEMBL816084 single protein format
CHEMBL341644 Ki = 220.0 nM 331.17 O=c1[nH]c(=O)n([C@H]2C[C@@H](CO)[C@H](O)C2)cc1/C=C/Br Homo sapiens CHEMBL816084 single protein format