P04114 | APOB_HUMAN | Apolipoprotein B-100 (APOB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01347 | Vitellogenin_N - Lipoprotein amino terminal region | 46~597 | |
| PF06448 | DUF1081 - Domain of Unknown Function (DUF1081) | 960~1071 | |
| PF09172 | Vit_open_b-sht - Vitellinogen, open beta-sheet | 632~937 | |
| PF12491 | ApoB100_C - Apolipoprotein B100 C terminal | 4494~4549 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL142450 |  |
IC50 | = | 0.7 | nM | 468.48 | COC(=O)N[C@H]1Cc2ccc(NC(=O)c3cccc(C)c3-c3ccc(C(F)(F)F)cc3)cc2C1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL336873 |  |
IC50 | = | 0.9 | nM | 556.63 | Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@H](NS(=O)(=O)c2cccs2)C3)c1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL139834 |  |
IC50 | = | 1.0 | nM | 570.66 | Cc1cc(C)c(-c2ccc(C(F)(F)F)cc2)c(C(=O)Nc2ccc3c(c2)C[C@H](NS(=O)(=O)c2cccs2)C3)c1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL143284 |  |
IC50 | = | 1.1 | nM | 482.5 | COC(=O)N[C@H]1Cc2ccc(NC(=O)c3cc(C)cc(C)c3-c3ccc(C(F)(F)F)cc3)cc2C1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL344814 |  |
IC50 | = | 1.2 | nM | 500.6 | Cc1cccc(C(=O)Nc2ccc3c(c2)CC(NS(=O)(=O)c2ccccc2)C3)c1-c1ccc(F)cc1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL357886 |  |
IC50 | = | 1.3 | nM | 536.58 | O=C(Nc1ccc2c(c1)CC(NS(=O)(=O)c1ccccc1)C2)c1ccccc1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL356091 |  |
IC50 | = | 1.4 | nM | 506.62 | Cc1cccc(C(=O)Nc2ccc3c(c2)CC(NS(=O)(=O)c2cccs2)C3)c1-c1ccc(F)cc1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL142975 |  |
IC50 | = | 1.6 | nM | 496.53 | COC(=O)NC1CCc2ccc(NC(=O)c3cccc(C)c3-c3ccc(C(F)(F)F)cc3)cc2CC1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL142272 |  |
IC50 | = | 1.6 | nM | 584.69 | Cc1cccc(C(=O)Nc2ccc3c(c2)CCC(NS(=O)(=O)c2cccs2)CC3)c1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL142972 |  |
IC50 | = | 1.7 | nM | 501.55 | Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@@H](NCc2ccccn2)C3)c1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL422295 |  |
IC50 | = | 1.8 | nM | 537.58 | COC(=O)N1CCN([C@H]2Cc3ccc(NC(=O)c4cccc(C)c4-c4ccc(C(F)(F)F)cc4)cc3C2)CC1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL142928 |  |
IC50 | = | 1.8 | nM | 522.44 | COC(=O)N[C@H]1Cc2ccc(NC(=O)c3cccc(C(F)(F)F)c3-c3ccc(C(F)(F)F)cc3)cc2C1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL359428 |  |
IC50 | = | 1.8 | nM | 488.53 | Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@H](NS(C)(=O)=O)C3)c1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL139992 |  |
IC50 | = | 1.9 | nM | 454.45 | COC(=O)N[C@H]1Cc2ccc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)cc2C1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL143626 |  |
IC50 | = | 1.9 | nM | 570.66 | Cc1cccc(C(=O)Nc2ccc3c(c2)CC(CNS(=O)(=O)c2cccs2)C3)c1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL343406 |  |
IC50 | = | 2.0 | nM | 533.05 | COc1cccc(C(=O)Nc2ccc3c(c2)CC(NS(=O)(=O)c2ccccc2)C3)c1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL356126 |  |
IC50 | = | 2.0 | nM | 462.98 | COC(=O)NC1CCc2ccc(NC(=O)c3cccc(C)c3-c3ccc(Cl)cc3)cc2CC1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL142733 |  |
IC50 | = | 2.2 | nM | 496.53 | COC(=O)NCC1Cc2ccc(NC(=O)c3cc(C)cc(C)c3-c3ccc(C(F)(F)F)cc3)cc2C1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL143514 |  |
IC50 | = | 2.2 | nM | 468.48 | COC(=O)N[C@H]1Cc2ccc(NC(=O)c3cc(C)ccc3-c3ccc(C(F)(F)F)cc3)cc2C1 | Homo sapiens | CHEMBL824105 | assay format |
| CHEMBL343874 |  |
IC50 | = | 2.3 | nM | 516.59 | Cc1cccc(C(=O)Nc2ccc3c(c2)CCC(NS(C)(=O)=O)CC3)c1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL824105 | assay format |