P04066 | FUCO_HUMAN | Tissue alpha-L-fucosidase (FUCA1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01120 | Alpha_L_fucos - Alpha-L-fucosidase | 30~367 | |
| PF16757 | Fucosidase_C - Alpha-L-fucosidase C-terminal domain | 378~463 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2442786 |  |
IC50 | = | 7.9 | nM | 298.31 | C[C@@H]1N[C@H](CC(=O)Nc2ccccc2F)[C@@H](O)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL114103 |  |
IC50 | = | 11.0 | nM | 219.24 | CC1C(O)C(O)C(O)C(CO)N1CC=O | Homo sapiens | CHEMBL819879 | single protein format |
| CHEMBL2442788 |  |
IC50 | = | 14.0 | nM | 298.31 | C[C@@H]1N[C@H](CC(=O)Nc2ccc(F)cc2)[C@@H](O)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL2442783 |  |
IC50 | = | 15.0 | nM | 294.35 | Cc1ccc(NC(=O)C[C@H]2N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)cc1 | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL2442784 |  |
IC50 | = | 19.0 | nM | 308.38 | Cc1ccc(NC(=O)C[C@H]2N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)c(C)c1 | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL2442779 |  |
IC50 | = | 26.0 | nM | 310.35 | COc1ccc(NC(=O)C[C@H]2N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)cc1 | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL2442782 |  |
IC50 | = | 30.0 | nM | 294.35 | Cc1cccc(NC(=O)C[C@H]2N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)c1 | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL2442777 |  |
IC50 | = | 30.0 | nM | 280.32 | C[C@@H]1N[C@H](CC(=O)Nc2ccccc2)[C@@H](O)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL2442787 |  |
IC50 | = | 31.0 | nM | 298.31 | C[C@@H]1N[C@H](CC(=O)Nc2cccc(F)c2)[C@@H](O)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL2442773 |  |
IC50 | = | 35.0 | nM | 316.3 | C[C@@H]1N[C@H](CC(=O)Nc2ccc(F)cc2F)[C@@H](O)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL539176 |  |
IC50 | = | 40.0 | nM | 293.32 | CC1NC(CO)(CNC(=O)[C@@H](N)CO)C(O)C(O)C1O | Homo sapiens | CHEMBL819879 | single protein format |
| CHEMBL115828 |  |
IC50 | = | 50.0 | nM | 263.29 | CC1NC(CO)(CNC(=O)CN)C(O)C(O)C1O | Homo sapiens | CHEMBL819879 | single protein format |
| CHEMBL2442781 |  |
IC50 | = | 58.0 | nM | 294.35 | Cc1ccccc1NC(=O)C[C@H]1N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL114487 |  |
IC50 | = | 75.0 | nM | 202.21 | CC1NC(C#N)(CO)C(O)C(O)C1O | Homo sapiens | CHEMBL819879 | single protein format |
| CHEMBL2442776 |  |
IC50 | = | 86.0 | nM | 265.35 | C[C@@H]1N[C@H](CCCc2ccccc2)[C@@H](O)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL314757 |  |
IC50 | = | 110.0 | nM | 273.42 | CCCCCCCCNC1CC(C)C(O)C(O)C1O | Homo sapiens | CHEMBL649574 | single protein format |
| CHEMBL2442780 |  |
IC50 | = | 130.0 | nM | 260.33 | CCCCNC(=O)C[C@H]1N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL2442774 |  |
IC50 | = | 180.0 | nM | 334.29 | C[C@@H]1N[C@H](CC(=O)Nc2c(F)cc(F)cc2F)[C@@H](O)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL2442778 |  |
IC50 | = | 190.0 | nM | 294.35 | C[C@@H]1N[C@H](CC(=O)NCc2ccccc2)[C@@H](O)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL2445277 | single protein format |
| CHEMBL2442785 |  |
IC50 | = | 200.0 | nM | 322.41 | Cc1cc(C)c(NC(=O)C[C@H]2N[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)c(C)c1 | Homo sapiens | CHEMBL2445277 | single protein format |