P04054 | PA21B_HUMAN | Phospholipase A2 (PLA2G1B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00068 | Phospholip_A2_1 - Phospholipase A2 | 24~137 |
3D structures mapped by conservation among orthologs
[ Domain: "Phospholipase A2, PLA2" // Phospholip_A2_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL121609 |  |
IC50 | = | 5.0 | nM | 430.46 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1cccc2ccccc12 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL121245 |  |
IC50 | = | 6.0 | nM | 414.85 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1cccc(Cl)c1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL331755 |  |
IC50 | = | 6.0 | nM | 470.53 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1ccccc1Cc1ccccc1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL332993 |  |
IC50 | = | 6.0 | nM | 456.5 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1ccccc1-c1ccccc1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL121627 |  |
IC50 | = | 8.0 | nM | 456.5 | COC(=O)COc1cccn2c(Cc3ccccc3-c3ccccc3)c(C)c(C(=O)C(N)=O)c12 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL121617 |  |
IC50 | = | 8.0 | nM | 380.4 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1ccccc1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL332547 |  |
IC50 | = | 8.0 | nM | 366.37 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1ccccc1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL121645 |  |
IC50 | = | 9.0 | nM | 468.51 | NC(=O)C(=O)c1c(C2CC2)c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(=O)O)c12 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL332957 |  |
IC50 | = | 9.0 | nM | 470.53 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)OC)cccn2c1Cc1cccc(-c2ccccc2)c1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL120112 |  |
IC50 | = | 9.0 | nM | 448.4 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL123182 |  |
IC50 | = | 10.0 | nM | 468.56 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1csc(-c2cccs2)c1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL414424 |  |
IC50 | = | 10.0 | nM | 372.42 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1CC1CCCCC1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL122736 |  |
IC50 | = | 11.0 | nM | 386.43 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1cccs1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL123774 |  |
IC50 | = | 11.0 | nM | 436.51 | CCCCc1ccc(Cc2c(CC)c(C(=O)C(N)=O)c3c(OCC(=O)O)cccn23)cc1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL123384 |  |
IC50 | = | 13.0 | nM | 366.42 | CCc1c(CC(N)=O)c2c(OCC(=O)O)cccn2c1Cc1ccccc1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL121030 |  |
IC50 | = | 13.0 | nM | 454.53 | NC(=O)Cc1c(C2CC2)c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(=O)O)c12 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL330987 |  |
IC50 | = | 14.0 | nM | 358.39 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1CC1CCCC1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL121481 |  |
IC50 | = | 14.0 | nM | 442.52 | CCc1c(CC(N)=O)c2c(OCC(=O)O)cccn2c1Cc1ccccc1-c1ccccc1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL121199 |  |
IC50 | = | 15.0 | nM | 400.86 | CCc1c(CC(N)=O)c2c(OCC(=O)O)cccn2c1Cc1cccc(Cl)c1 | Homo sapiens | CHEMBL760952 | single protein format |
| CHEMBL420169 |  |
IC50 | = | 15.0 | nM | 458.47 | COc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1ccccc1-c1ccccc1 | Homo sapiens | CHEMBL760952 | single protein format |