P04049 | RAF1_HUMAN | RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Pfam Domain Table

AccessionDomainRangeColor
PF00069Pkinase - Protein kinase domain352~605
PF00130C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain)139~185
PF02196RBD - Raf-like Ras-binding domain57~128

3D structures mapped by conservation among orthologs

[ Domain: "Ubiquitin-like" // RBD ]

 PyMOL session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session

[ Domain: "Cysteine-rich domain" // C1_1 ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3924812 IC50 = 0.024 nM 596.5 Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccn2)cc1-c1cc(OCC(O)CP(=O)(O)O)nc(N2CCOCC2)c1 Homo sapiens CHEMBL3865244 cell-based format
CHEMBL3961999 IC50 = 0.03 nM 582.47 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cnc(OCCOP(=O)(O)O)c(N2CCOCC2)c1 Homo sapiens CHEMBL3865244 cell-based format
CHEMBL3933272 IC50 = 0.039 nM 498.53 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)c2sccc2n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3951474 IC50 = 0.056 nM 423.46 Cc1ccc(NC(=O)c2cccc(C(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3905257 IC50 = 0.065 nM 481.48 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cn2ccnc2c(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3959581 IC50 = 0.09 nM 482.51 C=C(C)c1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3929689 IC50 = 0.1 nM 582.47 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCOP(=O)(O)O)nc(N2CCOCC2)c1 Homo sapiens CHEMBL3865244 cell-based format
CHEMBL3952506 IC50 = 0.1 nM 592.54 Cc1ccc(NC(=O)c2ccnc(C(C)(F)F)c2)cc1-c1cc(OCCOP(=O)(O)O)nc(N2CCOC[C@H]2C)c1 Homo sapiens CHEMBL3865244 cell-based format
CHEMBL3967893 IC50 = 0.103 nM 527.55 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3966766 IC50 = 0.103 nM 496.49 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CC#N)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3972141 IC50 = 0.11 nM 520.53 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(S(C)(=O)=O)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3919205 IC50 = 0.117 nM 456.47 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N)nc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3962812 IC50 = 0.119 nM 542.56 Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(OC2CCOCC2)c(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3914464 IC50 = 0.122 nM 467.52 Cc1ccc(NC(=O)c2cccc(C(C)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3907015 IC50 = 0.124 nM 451.55 Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1-c1ccnc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3942721 IC50 = 0.13 nM 527.55 Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)c1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3987177 IC50 = 0.132 nM 502.49 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(OCCO)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3928030 IC50 = 0.134 nM 508.5 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(-n2ccnc2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3976881 IC50 = 0.137 nM 503.61 Cc1ccc(NC(=O)c2cncc(N(C)C)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 Homo sapiens CHEMBL3887884 single protein format
CHEMBL3956654 IC50 = 0.145 nM 442.44 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)ncn1 Homo sapiens CHEMBL3887884 single protein format