P02753 | RET4_HUMAN | Retinol-binding protein 4 (RBP4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00061 | Lipocalin - Lipocalin / cytosolic fatty-acid binding protein family | 39~173 |
3D structures mapped by conservation among orthologs
[ Domain: "Lipocalins" // Lipocalin_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3358470 |  |
IC50 | = | 2.65 | nM | 382.34 | CN(CCOc1ccccc1C(F)(F)F)C(=O)Nc1ccccc1C(=O)O | Homo sapiens | CHEMBL3380010 | assay format |
| CHEMBL4462481 |  |
IC50 | = | 2.66 | nM | 388.39 | Cc1ccc2nc(C(=O)N3CCC(c4ccccc4C(F)(F)F)CC3)cn2n1 | Homo sapiens | CHEMBL4305280 | single protein format |
| CHEMBL4472596 |  |
IC50 | = | 2.7 | nM | 444.46 | CCOc1ccc2nnc(C(=O)N3C[C@H]4C[C@@H](c5ccccc5C(F)(F)F)C[C@H]4C3)n2c1 | Homo sapiens | CHEMBL4305280 | single protein format |
| CHEMBL3983972 |  |
IC50 | = | 2.88 | nM | 421.4 | N#CN1CCc2c(C(=O)N3CCC(c4cccc(F)c4C(F)(F)F)CC3)n[nH]c2C1 | Homo sapiens | CHEMBL3889135 | single protein format |
| CHEMBL3288340 |  |
IC50 | = | 3.0 | nM | 340.37 | O=C(c1nccs1)N1CCC(c2ccccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL3291833 | single protein format |
| CHEMBL3961492 |  |
IC50 | = | 3.104 | nM | 383.81 | N#Cc1ccc2nnc(C(=O)N3CCC(c4cccc(F)c4Cl)CC3)n2c1 | Homo sapiens | CHEMBL3889135 | single protein format |
| CHEMBL4546092 |  |
IC50 | = | 3.4 | nM | 468.4 | O=C(c1nnc2ccc(C(F)(F)F)cn12)N1C[C@H]2C[C@@H](c3ccccc3C(F)(F)F)C[C@H]2C1 | Homo sapiens | CHEMBL4305280 | single protein format |
| CHEMBL3890586 |  |
IC50 | = | 3.447 | nM | 439.39 | N#CN1CCc2c(C(=O)N3CCC(c4ccc(F)c(F)c4C(F)(F)F)CC3)n[nH]c2C1 | Homo sapiens | CHEMBL3889135 | single protein format |
| CHEMBL4469381 |  |
IC50 | = | 3.6 | nM | 414.43 | O=C(c1cn2nc(C3CC3)ccc2n1)N1CCC(c2ccccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL4305280 | single protein format |
| CHEMBL4452483 |  |
IC50 | = | 3.7 | nM | 404.39 | COc1ccc2nnc(C(=O)N3CCC(c4ccccc4C(F)(F)F)CC3)n2c1 | Homo sapiens | CHEMBL4305280 | single protein format |
| CHEMBL4532832 |  |
IC50 | = | 3.71 | nM | 387.4 | Cn1nc(C(=O)N2CCC(c3ccccc3C(F)(F)F)CC2)c2ccccc21 | Homo sapiens | CHEMBL4305280 | single protein format |
| CHEMBL4468564 |  |
IC50 | = | 3.75 | nM | 442.36 | O=C(c1nnc2ccc(C(F)(F)F)cn12)N1CCC(c2ccccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL4305280 | single protein format |
| CHEMBL3644466 |  |
IC50 | = | 3.8 | nM | 312.42 | CC(C)(C)c1ccccc1N1CCN(C(=O)c2c[nH]cn2)CC1 | Homo sapiens | CHEMBL3705730 | single protein format |
| CHEMBL4524379 |  |
IC50 | = | 3.9 | nM | 388.39 | Cc1ccc2nnc(C(=O)N3CCC(c4ccccc4C(F)(F)F)CC3)n2c1 | Homo sapiens | CHEMBL4305280 | single protein format |
| CHEMBL3358465 |  |
IC50 | = | 3.94 | nM | 531.56 | O=C(NS(=O)(=O)c1ccccc1)c1ccccc1NC(=O)N1CCC(c2ccccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL3380010 | assay format |
| CHEMBL4570619 |  |
IC50 | = | 3.97 | nM | 418.42 | CCOc1ccc2nnc(C(=O)N3CCC(c4ccccc4C(F)(F)F)CC3)n2c1 | Homo sapiens | CHEMBL4305280 | single protein format |
| CHEMBL4457361 |  |
IC50 | = | 4.01 | nM | 408.81 | O=C(c1nnc2ccc(Cl)cn12)N1CCC(c2ccccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL4305280 | single protein format |
| CHEMBL4559814 |  |
IC50 | = | 4.1 | nM | 418.39 | O=C(c1nnc2ccc(F)cn12)N1C[C@H]2C[C@@H](c3ccccc3C(F)(F)F)C[C@H]2C1 | Homo sapiens | CHEMBL4305280 | single protein format |
| CHEMBL4514302 |  |
IC50 | = | 4.12 | nM | 447.43 | O=C(c1nn(C2COC2)c2cc(F)ccc12)N1CCC(c2ccccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL4305280 | single protein format |
| CHEMBL3954871 |  |
IC50 | = | 4.128 | nM | 417.37 | N#Cc1ccc2nnc(C(=O)N3CCC(c4cccc(F)c4C(F)(F)F)CC3)n2c1 | Homo sapiens | CHEMBL3889135 | single protein format |