P01375 | TNFA_HUMAN | Tumor necrosis factor (TNF)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00229 | TNF - TNF(Tumour Necrosis Factor) family | 102~233 |
3D structures mapped by conservation among orthologs
[ Domain: "TNF-like" // TNF ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL2152944 | IC50 | = | 0.0 | nM | 425.43 | O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21 | Homo sapiens | CHEMBL4883804 | single protein format | |
CHEMBL4108792 | IC50 | = | 0.3 | nM | 522.99 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n([C@@H]3CCN(C(=O)OC(C)(C)C)C3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3954709 | IC50 | = | 0.3 | nM | 522.01 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(C(=O)NC(C)C)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3932863 | IC50 | = | 0.4 | nM | 544.03 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(S(=O)(=O)N(C)C)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3955760 | IC50 | = | 0.4 | nM | 543.05 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(S(=O)(=O)C(C)C)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3971431 | IC50 | = | 0.6 | nM | 507.98 | CCNC(=O)N1CCC(n2c(=O)n(-c3cccc(Cl)c3)c(=O)c3cnc4c(OC)cccc4c32)CC1 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3911773 | IC50 | = | 0.9 | nM | 449.94 | COc1cccc2c1ncc1c(=O)n(-c3ccc(Cl)cc3)c(=O)n(C3CCC(C)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3972551 | IC50 | = | 1.0 | nM | 389.46 | CCCCn1c(=O)n(-c2cccc(C)c2)c(=O)c2cnc3c(OC)cccc3c21 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3958848 | IC50 | = | 1.0 | nM | 429.52 | COc1cccc2c1ncc1c(=O)n(-c3cccc(C)c3)c(=O)n(C3CCC(C)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3966151 | IC50 | = | 1.0 | nM | 537.02 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(C(=O)OC(C)(C)C)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3931657 | IC50 | = | 1.0 | nM | 541.01 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(C(=O)c4ccccc4)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3962096 | IC50 | = | 1.0 | nM | 546.58 | COc1cccc2c1ncc1c(=O)n(-c3ccc4c(c3)OCO4)c(=O)n(C3CCN(C(=O)OC(C)(C)C)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3960339 | IC50 | = | 1.0 | nM | 577.06 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(S(=O)(=O)c4ccccc4)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3938524 | IC50 | = | 1.0 | nM | 479.92 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCC(C(=O)O)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3976439 | IC50 | = | 2.0 | nM | 478.94 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(C(C)=O)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3903807 | IC50 | = | 2.0 | nM | 522.99 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n([C@H]3CCN(C(=O)OC(C)(C)C)C3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3921402 | IC50 | = | 2.0 | nM | 471.89 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCC(F)(F)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3986640 | IC50 | = | 2.0 | nM | 529.02 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(CC3CCN(S(C)(=O)=O)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3644500 | IC50 | = | 2.0 | nM | 431.45 | COc1cccc2c1ncc1c(=O)n(-c3ccc4c(c3)OCO4)c(=O)n(C3CCCC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format | |
CHEMBL3644501 | IC50 | = | 2.4 | nM | 514.99 | COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(S(C)(=O)=O)CC3)c12 | Homo sapiens | CHEMBL3888583 | single protein format |