P01375 | TNFA_HUMAN | Tumor necrosis factor (TNF)

Pfam Domain Table

AccessionDomainRangeColor
PF00229TNF - TNF(Tumour Necrosis Factor) family102~233

3D structures mapped by conservation among orthologs

[ Domain: "TNF-like" // TNF ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL2152944 IC50 = 0.0 nM 425.43 O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21 Homo sapiens CHEMBL4883804 single protein format
CHEMBL4108792 IC50 = 0.3 nM 522.99 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n([C@@H]3CCN(C(=O)OC(C)(C)C)C3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3954709 IC50 = 0.3 nM 522.01 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(C(=O)NC(C)C)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3932863 IC50 = 0.4 nM 544.03 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(S(=O)(=O)N(C)C)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3955760 IC50 = 0.4 nM 543.05 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(S(=O)(=O)C(C)C)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3971431 IC50 = 0.6 nM 507.98 CCNC(=O)N1CCC(n2c(=O)n(-c3cccc(Cl)c3)c(=O)c3cnc4c(OC)cccc4c32)CC1 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3911773 IC50 = 0.9 nM 449.94 COc1cccc2c1ncc1c(=O)n(-c3ccc(Cl)cc3)c(=O)n(C3CCC(C)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3972551 IC50 = 1.0 nM 389.46 CCCCn1c(=O)n(-c2cccc(C)c2)c(=O)c2cnc3c(OC)cccc3c21 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3958848 IC50 = 1.0 nM 429.52 COc1cccc2c1ncc1c(=O)n(-c3cccc(C)c3)c(=O)n(C3CCC(C)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3966151 IC50 = 1.0 nM 537.02 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(C(=O)OC(C)(C)C)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3931657 IC50 = 1.0 nM 541.01 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(C(=O)c4ccccc4)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3962096 IC50 = 1.0 nM 546.58 COc1cccc2c1ncc1c(=O)n(-c3ccc4c(c3)OCO4)c(=O)n(C3CCN(C(=O)OC(C)(C)C)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3960339 IC50 = 1.0 nM 577.06 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(S(=O)(=O)c4ccccc4)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3938524 IC50 = 1.0 nM 479.92 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCC(C(=O)O)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3976439 IC50 = 2.0 nM 478.94 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(C(C)=O)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3903807 IC50 = 2.0 nM 522.99 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n([C@H]3CCN(C(=O)OC(C)(C)C)C3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3921402 IC50 = 2.0 nM 471.89 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCC(F)(F)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3986640 IC50 = 2.0 nM 529.02 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(CC3CCN(S(C)(=O)=O)CC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3644500 IC50 = 2.0 nM 431.45 COc1cccc2c1ncc1c(=O)n(-c3ccc4c(c3)OCO4)c(=O)n(C3CCCC3)c12 Homo sapiens CHEMBL3888583 single protein format
CHEMBL3644501 IC50 = 2.4 nM 514.99 COc1cccc2c1ncc1c(=O)n(-c3cccc(Cl)c3)c(=O)n(C3CCN(S(C)(=O)=O)CC3)c12 Homo sapiens CHEMBL3888583 single protein format