P01275 | GLUC_HUMAN | Pro-glucagon (GCG)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00123 | Hormone_2 - Peptide hormone | 53~80 | |
| PF00123 | Hormone_2 - Peptide hormone | 98~124 | |
| PF00123 | Hormone_2 - Peptide hormone | 146~173 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3617567 |  |
Ki | = | 5.55 | nM | 516.52 | CC1(C)CC(C(Nc2cnc(-n3cc(C(F)(F)F)cn3)nc2)c2ccc(C(=O)NCCC(=O)O)cc2)C1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3648156 |  |
Ki | = | 5.75 | nM | 515.53 | Cc1cc(OC(c2ccc(C(=O)NCCC(=O)O)cc2)C2CCC2)cc(C)c1-n1cc(C(F)(F)F)cn1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3648139 |  |
Ki | = | 7.6 | nM | 515.54 | CC1(C)CC(C(Nc2ccc(-n3cc(C(F)(F)F)cn3)nc2)c2ccc(C(=O)NCCC(=O)O)cc2)C1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3648191 |  |
Ki | = | 9.05 | nM | 515.54 | O=C(O)CCNC(=O)c1ccc([C@@H](Nc2ccc(-n3cc(C(F)(F)F)cn3)nc2)C2CCCCC2)cc1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3648133 |  |
Ki | = | 17.0 | nM | 515.54 | O=C(O)CCNC(=O)c1ccc(C(Nc2ccc(-n3cc(C(F)(F)F)cn3)nc2)C2CCCCC2)cc1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3648188 |  |
Ki | = | 20.2 | nM | 463.58 | CCC[C@H](Nc1ccc(-n2cc(C(C)(C)C)cn2)nc1)c1ccc(C(=O)NCCC(=O)O)cc1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3681967 |  |
Ki | = | 25.0 | nM | 449.53 | CC1(C)CC(C(Nc2cnc3cc(F)ccc3c2)c2ccc(C(=O)NCCC(=O)O)cc2)C1 | Homo sapiens | CHEMBL3705610 | assay format |
| CHEMBL3648192 |  |
Ki | = | 26.7 | nM | 515.54 | O=C(O)CCNC(=O)c1ccc([C@H](Nc2ccc(-n3cc(C(F)(F)F)cn3)nc2)C2CCCCC2)cc1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3648171 |  |
Ki | = | 27.4 | nM | 517.55 | Cc1cc([C@@H](CC(C)C)Nc2ccc(C(=O)NCCC(=O)O)cn2)cc(C)c1-n1cc(C(F)(F)F)cn1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3648167 |  |
Ki | = | 29.0 | nM | 483.57 | CCCC(Nc1ccc(-n2cc(-c3ccccc3)cn2)nc1)c1ccc(C(=O)NCCC(=O)O)cc1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3648151 |  |
Ki | = | 29.3 | nM | 483.57 | CCCC(Nc1ccc(-n2cnc(-c3ccccc3)c2)nc1)c1ccc(C(=O)NCCC(=O)O)cc1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3648187 |  |
Ki | = | 30.2 | nM | 463.58 | CCC[C@@H](Nc1ccc(-n2cc(C(C)(C)C)cn2)nc1)c1ccc(C(=O)NCCC(=O)O)cc1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3648164 |  |
Ki | = | 32.3 | nM | 519.52 | CCCC(Oc1cc(C)c(-n2cc(C(F)(F)F)cn2)c(OC)c1)c1ccc(C(=O)NCCC(=O)O)cc1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3617574 |  |
Ki | = | 33.0 | nM | 553.87 | O=C(O)CCNC(=O)c1ccc(-c2cc(Cl)ccc2CNc2ccc(-c3ccc(Cl)cc3Cl)cc2)cc1 | Homo sapiens | CHEMBL3705741 | cell-based format |
| CHEMBL3648186 |  |
Ki | = | 35.0 | nM | 515.54 | CC1(C)CC([C@H](Nc2ccc(-n3cnc(C(F)(F)F)c3)nc2)c2ccc(C(=O)NCCC(=O)O)cc2)C1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3648163 |  |
Ki | = | 35.2 | nM | 543.59 | Cc1cc(OC(c2ccc(C(=O)NCCC(=O)O)cc2)C2CC(C)(C)C2)cc(C)c1-n1cc(C(F)(F)F)cn1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3673117 |  |
Ki | = | 38.0 | nM | 513.53 | O=C(O)CCNC(=O)c1ccc(-c2ccccc2CNc2ccc(-c3ccc(F)c([N+](=O)[O-])c3)cc2)cc1 | Homo sapiens | CHEMBL3705741 | cell-based format |
| CHEMBL2381823 |  |
Ki | = | 38.2 | nM | 476.46 | CCCC(Nc1cnc(-n2cc(C(F)(F)F)cn2)nc1)c1ccc(C(=O)NCCC(=O)O)cc1 | Homo sapiens | CHEMBL3705314 | single protein format |
| CHEMBL3617569 |  |
Ki | = | 39.0 | nM | 463.55 | Cc1cc2cc(F)ccc2nc1NC(c1ccc(C(=O)NCCC(=O)O)cc1)C1CC(C)(C)C1 | Homo sapiens | CHEMBL3705610 | assay format |
| CHEMBL3648195 |  |
Ki | = | 41.0 | nM | 544.58 | CCOC(=O)CCNC(=O)c1ccc(C(Nc2cnc(-n3cc(C(F)(F)F)cn3)nc2)C2CC(C)(C)C2)cc1 | Homo sapiens | CHEMBL3705314 | single protein format |