P01116 | RASK_HUMAN | GTPase KRas (KRAS)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00071 | Ras - Ras family | 5~164 |
3D structures mapped by conservation among orthologs
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Ras ]
- 3GFT
- 4DSN
- 4DSO
- 4DST
- 4DSU
- 4EPR
- 4EPT
- 4EPV
- 4EPW
- 4EPX
- 4EPY
- 4L8G
- 4LDJ
- 4LPK
- 4LRW
- 4LUC
- 4LV6
- 4LYF
- 4LYH
- 4LYJ
- 4M1O
- 4M1S
- 4M1T
- 4M1W
- 4M1Y
- 4M21
- 4M22
- 4NMM
- 4OBE
- 4PZY
- 4PZZ
- 4Q01
- 4Q02
- 4Q03
- 4QL3
- 4TQ9
- 4TQA
- 4WA7
- 5F2E
- 5KYK
- 5MLA
- 5MLB
- 5O2S
- 5O2T
- 5OCG
- 5OCO
- 5OCT
- 5TAR
- 5TB5
- 5UFE
- 5UFQ
- 5UK9
- 5UQW
- 5US4
- 5USJ
- 5V6S
- 5V6V
- 5V71
- 5V9L
- 5V9O
- 5V9U
- 5VBM
- 5VP7
- 5VPI
- 5VPY
- 5VPZ
- 5VQ0
- 5VQ1
- 5VQ2
- 5VQ6
- 5VQ8
- 5W22
- 5WHA
- 5WHB
- 5WHD
- 5WHE
- 5WLB
- 5WPM
- 5XCO
- 5YXZ
- 5YY1
- 6ARK
- 6ASA
- 6ASE
- 6B0V
- 6B0Y
- 6BOF
- 6BP1
- 6CC9
- 6CCH
- 6CCX
- 6CU6
- 6E6F
- 6E6G
- 6EPL
- 6EPM
- 6EPN
- 6EPO
- 6EPP
- 6F76
- 6FA1
- 6FA2
- 6FA3
- 6FA4
- 6GJ5
- 6GJ6
- 6GJ7
- 6GJ8
- 6GOD
- 6GOE
- 6GOF
- 6GOG
- 6GOM
- 6GQT
- 6GQW
- 6GQX
- 6GQY
- 6H46
- 6H47
- 6M9W
- 6MBQ
- 6MBT
- 6MBU
- 6MQG
- 6MQN
- 6N2J
- 6N2K
- 6OB2
- 6OB3
- 6OIM
- 6P0Z
- 6P8W
- 6P8X
- 6P8Y
- 6P8Z
- 6PGO
- 6PGP
- 6QUU
- 6QUV
- 6QUW
- 6QUX
- 6V5L
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4855757 |  |
IC50 | = | 0.1 | nM | 572.66 | Oc1cc(-c2ncc3c(N4CC5CCC(C4)N5)nc(OCC45CCCN4C(CF)CC5)nc3c2F)c2ccccc2c1 | Homo sapiens | CHEMBL4845550 | single protein format |
| CHEMBL4857438 |  |
IC50 | = | 0.2 | nM | 593.08 | Oc1cc(-c2ncc3c(N4CC5CCC(C4)N5)nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)c2c(Cl)cccc2c1 | Homo sapiens | CHEMBL4845550 | single protein format |
| CHEMBL4863339 |  |
IC50 | = | 0.3 | nM | 564.67 | C#Cc1cccc2cc(O)cc(-c3ncc4c(N5CC6CCC(C5)N6)nc(OCC56CCCN5CCC6)nc4c3F)c12 | Homo sapiens | CHEMBL4845550 | single protein format |
| CHEMBL4876040 |  |
IC50 | = | 0.4 | nM | 582.66 | C#Cc1cccc2cc(O)cc(-c3ncc4c(N5CC6CCC(C5)N6)nc(OC[C@@]56CCCN5C[C@H](F)C6)nc4c3F)c12 | Homo sapiens | CHEMBL4845550 | single protein format |
| CHEMBL4859236 |  |
IC50 | = | 0.4 | nM | 575.09 | Oc1cc(-c2ncc3c(N4CC5CCC(C4)N5)nc(OCC45CCCN4CCC5)nc3c2F)c2c(Cl)cccc2c1 | Homo sapiens | CHEMBL4845550 | single protein format |
| CHEMBL4857719 |  |
IC50 | = | 0.5 | nM | 593.08 | Oc1cc(-c2ncc3c(N4CC5CCC(C4)N5)nc(OCC45CCCN4CCC5)nc3c2F)c2c(Cl)c(F)ccc2c1 | Homo sapiens | CHEMBL4845550 | single protein format |
| CHEMBL4876243 |  |
IC50 | = | 0.6 | nM | 588.66 | COC1CN2CCCC2(COc2nc(N3CC4CCC(C3)N4)c3cnc(-c4cc(O)cc5cccc(F)c45)c(F)c3n2)C1 | Homo sapiens | CHEMBL4845550 | single protein format |
| CHEMBL4874297 |  |
IC50 | = | 0.6 | nM | 594.61 | Oc1cc(-c2ncc3c(N4CC5CCC(C4)N5)nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)c2c(F)c(F)ccc2c1 | Homo sapiens | CHEMBL4845550 | single protein format |
| CHEMBL4867851 |  |
IC50 | = | 0.6 | nM | 582.66 | C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N5CC6CCC(C5)N6)nc(OCC56CCCN5CCC6)nc4c3F)c12 | Homo sapiens | CHEMBL4845550 | single protein format |
| CHEMBL5290459 |  |
IC50 | = | 1.0 | nM | 598.09 | Oc1cc(Cl)c(C2CC2)c(-c2ncc3c(N4CCCC5(CCO5)C4)nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)c1 | Homo sapiens | CHEMBL5256825 | single protein format |
| CHEMBL4648852 |  |
IC50 | = | 1.0 | nM | 586.14 | C=CC(=O)N1CCN(c2nc(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(Cl)c24)C3)C[C@@H]1CC#N | Homo sapiens | CHEMBL4612347 | cell-based format |
| CHEMBL4632935 |  |
IC50 | = | 1.0 | nM | 565.72 | C=CC(=O)N1CCN(c2nc(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)C[C@@H]1CC#N | Homo sapiens | CHEMBL4612347 | cell-based format |
| CHEMBL5430198 |  |
IC50 | = | 1.3 | nM | 596.11 | CN1CCC[C@H]1COc1nc(N2CC3CCC(C2)N3)c2cc(Cl)c(-c3ccc(F)c4sc(N)c(C#N)c34)c(F)c2n1 | Homo sapiens | CHEMBL5374156 | single protein format |
| CHEMBL5416793 |  |
IC50 | = | 3.0 | nM | 486.91 | C=CC(=O)N1C[C@H]2CCOc3c(Cl)c(-c4c(O)cccc4F)c(F)c4ncnc(c34)N2C[C@H]1C | Homo sapiens | CHEMBL5335102 | assay format |
| CHEMBL5183988 |  |
IC50 | = | 3.0 | nM | 486.91 | C=CC(=O)N1C[C@@H]2CCOc3c(Cl)c(-c4c(O)cccc4F)c(F)c4ncnc(c34)N2C[C@H]1C | Homo sapiens | CHEMBL5166128 | assay format |
| CHEMBL4857517 |  |
IC50 | = | 3.2 | nM | 570.74 | Cc1cccc2cc(O)cc(N3CCc4c(nc(OCC5(CN6CCOCC6)CC5)nc4N4CC5CCC(C4)N5)C3)c12 | Homo sapiens | CHEMBL4837101 | assay format |
| CHEMBL5418527 |  |
IC50 | = | 3.5 | nM | 580.03 | Cc1cc(N)nc(-c2c(Cl)cc3c(N4CC5CCC(C4)N5)nc(OC[C@@H]4CCCN4C)nc3c2F)c1C(F)(F)F | Homo sapiens | CHEMBL5374156 | single protein format |
| CHEMBL5267907 |  |
IC50 | = | 4.0 | nM | 570.1 | C=CC(=O)N1CC2(CC(n3nc(-c4ccc5nn(CCOC)cc5c4)c(-c4c(Cl)c(C)cc5[nH]ncc45)c3C)C2)C1 | Homo sapiens | CHEMBL5238478 | cell-based format |
| CHEMBL4866126 |  |
IC50 | = | 4.3 | nM | 586.64 | C=CC(=O)N1CCN(c2nc(=O)n3c4nc(c(F)cc24)-c2c(F)cccc2OCCCc2ccnc(C(C)C)c2-3)[C@@H](C)C1 | Homo sapiens | CHEMBL4825224 | single protein format |
| CHEMBL4876344 |  |
IC50 | = | 4.4 | nM | 571.06 | C=CC(=O)N1CCN(c2c(C#N)c(=O)n(-c3c(C)ccnc3C(C)C)c3nc(-c4ccccc4F)c(Cl)cc23)CC1 | Homo sapiens | CHEMBL4845546 | single protein format |