P01031 | CO5_HUMAN | Complement C5 (C5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00207 | A2M - Alpha-2-macroglobulin family | 772~859 | |
| PF01759 | NTR - UNC-6/NTR/C345C module | 1551~1658 | |
| PF01821 | ANATO - Anaphylotoxin-like domain | 698~732 | |
| PF01835 | MG2 - MG2 domain | 126~219 | |
| PF07677 | A2M_recep - A-macroglobulin receptor binding domain | 1419~1510 | |
| PF07678 | TED_complement - A-macroglobulin TED domain | 978~1300 | |
| PF07703 | A2M_BRD - Alpha-2-macroglobulin bait region domain | 468~611 | |
| PF17789 | MG4 - Macroglobulin domain MG4 | 355~457 | |
| PF17790 | MG1 - Macroglobulin domain MG1 | 20~120 | |
| PF17791 | MG3 - Macroglobulin domain MG3 | 221~304 | |
| PF21309 | C5_CUB - Complement component 5, CUB domain | 1311~1366 |
3D structures mapped by conservation among orthologs
[ Domain: "TIMP-like" // NTR ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // A2M_N_2 ]
[ Domain: "Common fold of diphtheria toxin/transcription factors/cytochrome f" // A2M_recep ]
[ Domain: "alpha/alpha toroid" // A2M_comp ]
[ Domain: "Anaphylotoxins (complement system)" // ANATO ]
[ Domain: "Spermadhesin, CUB domain" // EUF07662 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // A2M_N_1 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // KOG1366_2nd_1 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // MG4 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // KOG1366_1st ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // ANATO,A2M_N_2 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // A2M_C ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // A2M_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4757748 |  |
IC50 | <= | 5.0 | nM | 400.52 | COc1ccc(NC(=O)N[C@@H](C)c2ccccc2OC)cc1OCCCC(C)C | Homo sapiens | CHEMBL4668571 | cell-free format |
| CHEMBL2203296 |  |
IC50 | = | 210.0 | nM | 370.49 | CCCCCCOc1cc(NC(=O)N[C@@H](C)c2ccccc2)ccc1OC | Homo sapiens | CHEMBL4668571 | cell-free format |
| CHEMBL2204196 |  |
IC50 | = | 440.0 | nM | 370.49 | COc1ccc(NC(=O)N[C@@H](C)c2ccccc2)cc1OCCCC(C)C | Homo sapiens | CHEMBL4668571 | cell-free format |
| CHEMBL4756677 |  |
IC50 | = | 620.0 | nM | 414.5 | COc1cc(C(=O)O)c(NC(=O)N[C@@H](C)c2ccccc2)cc1OCCCC(C)C | Homo sapiens | CHEMBL4668571 | cell-free format |