P00915 | CAH1_HUMAN | Carbonic anhydrase 1 (CA1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00194 | Carb_anhydrase - Eukaryotic-type carbonic anhydrase | 12~261 |
3D structures mapped by conservation among orthologs
[ Domain: "Carbonic anhydrase" // Carb_anhydrase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4100496 |  |
IC50 | = | 0.14 | nM | 469.98 | O=C(CSc1nnc(Nc2ccccc2)s1)N/N=C/c1ccc(-c2ccc(Cl)cc2)o1 | Homo sapiens | CHEMBL4035706 | cell membrane format |
| CHEMBL4073678 |  |
IC50 | = | 0.21 | nM | 480.53 | O=C(CSc1nnc(Nc2ccccc2)s1)N/N=C/c1ccc(-c2ccccc2[N+](=O)[O-])o1 | Homo sapiens | CHEMBL4035706 | cell membrane format |
| CHEMBL4098116 |  |
IC50 | = | 0.28 | nM | 514.98 | O=C(CSc1nnc(Nc2ccccc2)s1)N/N=C/c1ccc(-c2ccc(Cl)cc2[N+](=O)[O-])o1 | Homo sapiens | CHEMBL4035706 | cell membrane format |
| CHEMBL4099344 |  |
IC50 | = | 0.288 | nM | 385.54 | O=C(CSC(=S)NN1CCSCC1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL4041636 | single protein format |
| CHEMBL4082551 |  |
IC50 | = | 0.29 | nM | 480.53 | O=C(CSc1nnc(Nc2ccccc2)s1)N/N=C/c1ccc(-c2ccc([N+](=O)[O-])cc2)o1 | Homo sapiens | CHEMBL4035706 | cell membrane format |
| CHEMBL4097972 |  |
IC50 | = | 0.29 | nM | 504.42 | O=C(CSc1nnc(Nc2ccccc2)s1)N/N=C/c1ccc(-c2ccc(Cl)cc2Cl)o1 | Homo sapiens | CHEMBL4035706 | cell membrane format |
| CHEMBL4081323 |  |
IC50 | = | 0.346 | nM | 369.47 | O=C(CSC(=S)NN1CCOCC1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL4041636 | single protein format |
| CHEMBL4076887 |  |
IC50 | = | 0.45 | nM | 504.42 | O=C(CSc1nnc(Nc2ccccc2)s1)N/N=C/c1ccc(-c2ccc(Cl)c(Cl)c2)o1 | Homo sapiens | CHEMBL4035706 | cell membrane format |
| CHEMBL4060713 |  |
IC50 | = | 0.518 | nM | 444.58 | O=C(CSC(=S)NN1CCN(c2ccccc2)CC1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL4041636 | single protein format |
| CHEMBL4062231 |  |
IC50 | = | 0.535 | nM | 382.51 | CN1CCN(NC(=S)SCC(=O)NCc2ccc3c(c2)OCO3)CC1 | Homo sapiens | CHEMBL4041636 | single protein format |
| CHEMBL4089189 |  |
IC50 | = | 0.556 | nM | 367.5 | O=C(CSC(=S)NN1CCCCC1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL4041636 | single protein format |
| CHEMBL4072122 |  |
IC50 | = | 0.56 | nM | 480.53 | O=C(CSc1nnc(Nc2ccccc2)s1)N/N=C/c1ccc(-c2cccc([N+](=O)[O-])c2)o1 | Homo sapiens | CHEMBL4035706 | cell membrane format |
| CHEMBL4064130 |  |
IC50 | = | 0.57 | nM | 469.98 | O=C(CSc1nnc(Nc2ccccc2)s1)N/N=C/c1ccc(-c2cccc(Cl)c2)o1 | Homo sapiens | CHEMBL4035706 | cell membrane format |
| CHEMBL4082586 |  |
IC50 | = | 0.624 | nM | 474.61 | COc1ccc(N2CCN(NC(=S)SCC(=O)NCc3ccc4c(c3)OCO4)CC2)cc1 | Homo sapiens | CHEMBL4041636 | single protein format |
| CHEMBL4072105 |  |
IC50 | = | 0.677 | nM | 396.54 | CCN1CCN(NC(=S)SCC(=O)NCc2ccc3c(c2)OCO3)CC1 | Homo sapiens | CHEMBL4041636 | single protein format |
| CHEMBL4069396 |  |
IC50 | = | 0.699 | nM | 446.56 | O=C(CSC(=S)NN1CCN(c2ncccn2)CC1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL4041636 | single protein format |
| CHEMBL4105008 |  |
IC50 | = | 0.77 | nM | 469.98 | O=C(CSc1nnc(Nc2ccccc2)s1)N/N=C/c1ccc(-c2ccccc2Cl)o1 | Homo sapiens | CHEMBL4035706 | cell membrane format |
| CHEMBL4090426 |  |
IC50 | = | 0.903 | nM | 489.58 | O=C(CSC(=S)NN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL4041636 | single protein format |
| CHEMBL4061017 |  |
IC50 | = | 1.69 | nM | 381.52 | CC1CCN(NC(=S)SCC(=O)NCc2ccc3c(c2)OCO3)CC1 | Homo sapiens | CHEMBL4041636 | single protein format |
| CHEMBL2392425 |  |
IC50 | = | 2.13 | nM | 454.33 | NS(=O)(=O)c1ccc(/N=C2/NC(=O)/C(=C/c3cc(O)ccc3Br)S2)cc1 | Homo sapiens | CHEMBL2394011 | cell-based format |