P00751 | CFAB_HUMAN | Complement factor B (CFB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00084 | Sushi - Sushi repeat (SCR repeat) | 53~85 | |
| PF00084 | Sushi - Sushi repeat (SCR repeat) | 103~158 | |
| PF00084 | Sushi - Sushi repeat (SCR repeat) | 176~218 | |
| PF00089 | Trypsin - Trypsin | 489~730 | |
| PF00092 | VWA - von Willebrand factor type A domain | 270~466 |
3D structures mapped by conservation among orthologs
[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]
[ Domain: "vWA-like" // VWA ]
[ Domain: "Complement control module/SCR domain" // Sushi ]
[ Domain: "Complement control module/SCR domain" // Sushi_3 ]
[ Domain: "Complement control module/SCR domain" // Sushi_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4114217 |  |
IC50 | = | 1.0 | nM | 507.57 | CCN[C@H](CC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)c(F)c3n2)CC1)c1ccc(C#N)cc1 | Homo sapiens | CHEMBL4229714 | cell-based format |
| CHEMBL4639592 |  |
IC50 | = | 6.0 | nM | 432.56 | CCO[C@H]1CCN(Cc2c(C3CC3)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 | Homo sapiens | CHEMBL4614752 | single protein format |
| CHEMBL4594448 |  |
IC50 | = | 12.0 | nM | 422.53 | CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 | Homo sapiens | CHEMBL4614752 | single protein format |
| CHEMBL4644208 |  |
IC50 | = | 18.0 | nM | 406.53 | CCO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 | Homo sapiens | CHEMBL4614752 | single protein format |
| CHEMBL4632794 |  |
IC50 | = | 18.0 | nM | 408.5 | COc1cc(C)c2[nH]ccc2c1CN1CC[C@H](OC)C[C@H]1c1ccc(C(=O)O)cc1 | Homo sapiens | CHEMBL4614752 | single protein format |
| CHEMBL4641109 |  |
IC50 | = | 18.0 | nM | 418.54 | CO[C@H]1CCN(Cc2c(C3CC3)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 | Homo sapiens | CHEMBL4614752 | single protein format |
| CHEMBL4247942 |  |
IC50 | = | 23.0 | nM | 388.39 | CNC(c1nc2ccc(C#N)cc2[nH]1)(c1c(C)cc(C)cc1OC)C(F)(F)F | Homo sapiens | CHEMBL4229713 | cell-based format |
| CHEMBL4646504 |  |
IC50 | = | 24.0 | nM | 392.5 | CO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 | Homo sapiens | CHEMBL4614752 | single protein format |
| CHEMBL3894205 |  |
IC50 | = | 30.0 | nM | 414.39 | CNC(c1nc2cc(C#N)cnc2[nH]1)(c1c(OC)cc(C)c2[nH]ccc12)C(F)(F)F | Homo sapiens | CHEMBL3889177 | cell-based format |
| CHEMBL3954424 |  |
IC50 | = | 40.0 | nM | 346.39 | COc1cc(C)c2[nH]ccc2c1C(C)(N)c1nc2cc(C#N)cnc2[nH]1 | Homo sapiens | CHEMBL3889177 | cell-based format |
| CHEMBL3927308 |  |
IC50 | = | 40.0 | nM | 345.41 | COc1cc(C)c2[nH]ccc2c1C(C)(C)c1nc2cc(C#N)cnc2[nH]1 | Homo sapiens | CHEMBL3889177 | cell-based format |
| CHEMBL3908792 |  |
IC50 | = | 50.0 | nM | 347.38 | COc1cc(C)c2[nH]ccc2c1C(C)(O)c1nc2cc(C#N)cnc2[nH]1 | Homo sapiens | CHEMBL3889177 | cell-based format |
| CHEMBL3913748 |  |
IC50 | = | 60.0 | nM | 357.42 | Cc1cc(C2CC2)c(C(C)(O)c2nc3cc(C#N)cnc3[nH]2)c2cc[nH]c12 | Homo sapiens | CHEMBL3889177 | cell-based format |
| CHEMBL4644994 |  |
IC50 | = | 62.0 | nM | 362.47 | Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(C(=O)O)cc1 | Homo sapiens | CHEMBL4614752 | single protein format |
| CHEMBL3945639 |  |
IC50 | = | 90.0 | nM | 333.35 | COc1cc(C)c2[nH]ccc2c1C(O)c1nc2ncc(C#N)cc2[nH]1 | Homo sapiens | CHEMBL3889177 | cell-based format |
| CHEMBL3958120 |  |
IC50 | = | 90.0 | nM | 410.4 | Cc1cc(C2CC2)c(C(N)(c2nc3cc(C#N)cnc3[nH]2)C(F)(F)F)c2cc[nH]c12 | Homo sapiens | CHEMBL3889177 | cell-based format |
| CHEMBL3899277 |  |
IC50 | = | 100.0 | nM | 399.38 | CCc1cc(C)c2[nH]ccc2c1C(O)(c1nc2cc(C#N)cnc2[nH]1)C(F)(F)F | Homo sapiens | CHEMBL3889177 | cell-based format |
| CHEMBL3949381 |  |
IC50 | = | 290.0 | nM | 400.36 | COc1cc(C)c2[nH]ccc2c1C(N)(c1nc2cc(C#N)cnc2[nH]1)C(F)(F)F | Homo sapiens | CHEMBL3889177 | cell-based format |
| CHEMBL3904754 |  |
IC50 | = | 295.0 | nM | 360.42 | CNC(C)(c1nc2cc(C#N)cnc2[nH]1)c1c(OC)cc(C)c2[nH]ccc12 | Homo sapiens | CHEMBL3889177 | cell-based format |
| CHEMBL3910541 |  |
IC50 | = | 460.0 | nM | 343.39 | Cc1cc(C2CC2)c(C(O)c2nc3cc(C#N)cnc3[nH]2)c2cc[nH]c12 | Homo sapiens | CHEMBL3889177 | cell-based format |