P00748 | FA12_HUMAN | Coagulation factor XII (F12)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00008 | EGF - EGF-like domain | 98~129 | |
| PF00008 | EGF - EGF-like domain | 178~207 | |
| PF00039 | fn1 - Fibronectin type I domain | 135~170 | |
| PF00040 | fn2 - Fibronectin type II domain | 47~88 | |
| PF00051 | Kringle - Kringle domain | 217~295 | |
| PF00089 | Trypsin - Trypsin | 373~609 |
3D structures mapped by conservation among orthologs
[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]
[ Domain: "EGF/Laminin" // hEGF_6 ]
[ Domain: "Fibronectin type I module" // fn1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4776259 |  |
IC50 | = | 29.0 | nM | 315.34 | Nc1nc(-c2ccccn2)nn1C(=O)c1cccc2ccccc12 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4786270 |  |
IC50 | = | 62.0 | nM | 405.2 | Nc1nc(-c2ccccn2)nn1C(=O)Cc1ccccc1I | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4777212 |  |
IC50 | = | 91.0 | nM | 293.33 | Cc1ccc(C(=O)n2nc(-c3ccccn3)nc2N)cc1C | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4783236 |  |
IC50 | = | 93.0 | nM | 279.3 | Cc1cccc(C(=O)n2nc(-c3ccccn3)nc2N)c1 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4746556 |  |
IC50 | = | 106.0 | nM | 265.28 | O=C(Nc1nc(-c2ccncc2)n[nH]1)c1ccccc1 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4761275 |  |
IC50 | = | 109.0 | nM | 384.4 | Nc1nc(-c2ccccn2)nn1C(=O)c1ccc(NC(=O)c2ccccc2)cc1 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4748137 |  |
IC50 | = | 132.0 | nM | 265.28 | O=C(Nc1nc(-c2ccccn2)n[nH]1)c1ccccc1 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4760132 |  |
IC50 | = | 134.0 | nM | 319.37 | Nc1nc(-c2ccccn2)nn1C(=O)[C@H]1CCCc2ccccc21 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4754247 |  |
IC50 | = | 138.0 | nM | 315.34 | Nc1nc(-c2ccccn2)nn1C(=O)c1ccc2ccccc2c1 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4749147 |  |
IC50 | = | 142.0 | nM | 376.3 | Nc1nc(-c2ccccn2)nn1C(=O)c1ccc(NC(=O)C(F)(F)F)cc1 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4207969 |  |
IC50 | = | 160.0 | nM | 325.33 | COc1ccc(C(=O)n2nc(-c3cccnc3)nc2N)cc1OC | Homo sapiens | CHEMBL4193988 | single protein format |
| CHEMBL4750895 |  |
IC50 | = | 162.0 | nM | 293.33 | CCc1ccc(C(=O)n2nc(-c3ccccn3)nc2N)cc1 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL521527 |  |
IC50 | = | 180.0 | nM | 450.97 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1)C(=O)CCl | Homo sapiens | CHEMBL1005173 | single protein format |
| CHEMBL5425528 |  |
IC50 | = | 190.0 | nM | 264.09 | Nc1nccc2cc(-c3cccc(B(O)O)c3)ccc12 | Homo sapiens | CHEMBL5338479 | single protein format |
| CHEMBL4740475 |  |
IC50 | = | 210.0 | nM | 279.3 | Nc1nc(-c2ccccn2)nn1C(=O)Cc1ccccc1 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4646710 |  |
IC50 | = | 241.0 | nM | 495.67 | CC[C@@H](C)[C@@H](NC1CCCCC1)C(=O)N1C[C@@](C)(O)C[C@H]1C(=O)NCc1ccc2c(N)nccc2c1 | Homo sapiens | CHEMBL4623474 | single protein format |
| CHEMBL4786773 |  |
IC50 | = | 291.0 | nM | 295.3 | COc1ccc(C(=O)n2nc(-c3ccccn3)nc2N)cc1 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4797183 |  |
IC50 | = | 298.0 | nM | 265.28 | O=C(Nc1nc(-c2cccnc2)n[nH]1)c1ccccc1 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4754712 |  |
IC50 | = | 306.0 | nM | 283.27 | Nc1nc(-c2ccccn2)nn1C(=O)c1ccc(F)cc1 | Homo sapiens | CHEMBL4676505 | single protein format |
| CHEMBL4640835 |  |
IC50 | = | 341.0 | nM | 481.64 | CC[C@@H](C)[C@@H](NC1CCCCC1)C(=O)N1C[C@@H](O)C[C@H]1C(=O)NCc1ccc2c(N)nccc2c1 | Homo sapiens | CHEMBL4623474 | single protein format |