P00736 | C1R_HUMAN | Complement C1r subcomponent (C1R)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00084 | Sushi - Sushi repeat (SCR repeat) | 309~371 | |
| PF00084 | Sushi - Sushi repeat (SCR repeat) | 376~439 | |
| PF00089 | Trypsin - Trypsin | 464~697 | |
| PF00431 | CUB - CUB domain | 25~126 | |
| PF00431 | CUB - CUB domain | 193~302 | |
| PF14670 | FXa_inhibition - Coagulation Factor Xa inhibitory site | 160~189 |
3D structures mapped by conservation among orthologs
[ Domain: "FMN-binding split barrel 2" // Trypsin ]
[ Domain: "Spermadhesin, CUB domain" // CUB ]
[ Domain: "EGF/Laminin" // EGF_CA ]
[ Domain: "Complement control module/SCR domain" // Sushi ]
[ Domain: "Complement control module/SCR domain" // Sushi_3 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL10770 |  |
IC50 | = | 200.0 | nM | 414.2 | O=c1oc(Nc2ccccc2I)nc2cc3ccccc3cc12 | Homo sapiens | CHEMBL655961 | single protein format |
| CHEMBL10312 |  |
IC50 | = | 400.0 | nM | 432.14 | O=c1oc(Nc2ccccc2I)nc2cc(C(F)(F)F)ccc12 | Homo sapiens | CHEMBL655961 | single protein format |
| CHEMBL10610 |  |
IC50 | = | 400.0 | nM | 341.58 | O=c1oc(Nc2c(Cl)cccc2Cl)nc2cc(Cl)ccc12 | Homo sapiens | CHEMBL655961 | single protein format |
| CHEMBL10569 |  |
IC50 | = | 500.0 | nM | 433.03 | O=c1oc(Nc2ccccc2I)nc2cc(Cl)c(Cl)cc12 | Homo sapiens | CHEMBL655961 | single protein format |
| CHEMBL4247936 |  |
IC50 | = | 600.0 | nM | 536.49 | CC(C)[C@@H](NC(=O)Cc1c(Cl)cccc1Cl)C(=O)N1CC=CC1C(=O)NCc1ccc(C(=N)N)s1 | Homo sapiens | CHEMBL4229689 | single protein format |
| CHEMBL10432 |  |
IC50 | = | 700.0 | nM | 398.59 | O=c1oc(Nc2ccccc2I)nc2cc(Cl)ccc12 | Homo sapiens | CHEMBL655961 | single protein format |
| CHEMBL158926 |  |
IC50 | = | 700.0 | nM | 399.19 | O=c1oc(-c2ccccc2I)nc2cc3ccccc3cc12 | Homo sapiens | CHEMBL655965 | single protein format |
| CHEMBL166801 |  |
IC50 | = | 700.0 | nM | 346.36 | COc1ccc(S(=O)(=O)N(C)c2nc3ccccc3c(=O)o2)cc1 | Homo sapiens | CHEMBL661597 | single protein format |
| CHEMBL10065 |  |
IC50 | = | 800.0 | nM | 409.14 | O=c1oc(Nc2ccccc2I)nc2cc([N+](=O)[O-])ccc12 | Homo sapiens | CHEMBL655961 | single protein format |
| CHEMBL274319 |  |
IC50 | = | 800.0 | nM | 307.14 | O=c1oc(Nc2ccccc2Cl)nc2cc(Cl)ccc12 | Homo sapiens | CHEMBL655961 | single protein format |
| CHEMBL10248 |  |
IC50 | = | 800.0 | nM | 378.17 | Cc1ccc2c(=O)oc(Nc3ccccc3I)nc2c1 | Homo sapiens | CHEMBL655961 | single protein format |
| CHEMBL10132 |  |
IC50 | = | 900.0 | nM | 286.72 | Cc1ccc2c(=O)oc(Nc3ccccc3Cl)nc2c1 | Homo sapiens | CHEMBL655960 | single protein format |
| CHEMBL10252 |  |
IC50 | = | 900.0 | nM | 307.14 | O=c1oc(Nc2c(Cl)cccc2Cl)nc2ccccc12 | Homo sapiens | CHEMBL655961 | single protein format |
| CHEMBL273264 |  |
IC50 | = | 1000.0 | nM | 347.38 | N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 | Homo sapiens | CHEMBL655965 | single protein format |