ProtHub

P00734 | THRB_HUMAN | Prothrombin (F2)

Pfam Domain Table

Accession	Domain	Range
PF00051	Kringle - Kringle domain	108~186
PF00051	Kringle - Kringle domain	213~291
PF00089	Trypsin - Trypsin	364~613
PF00594	Gla - Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain	48~88
PF09396	Thrombin_light - Thrombin light chain	317~363

3D structures mapped by conservation among orthologs

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV Ki CSV

Only the first 20 rows are shown.

molecule_chembl_id	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL275366	IC50	=	0.0017	nM	418.5	NC(N)=NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccccc1)C(=O)O	Homo sapiens	CHEMBL816070	single protein format
CHEMBL105819	IC50	=	0.008	nM	555.64	CC(O)[C@@H](C(=O)N[C@H](C)c1ccccc1)N(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)CCCN=C(N)N	Homo sapiens	CHEMBL815795	single protein format
CHEMBL4108739	IC50	=	0.01	nM	505.97	COc1cc(C(=O)N2CC(C)(CCO)OC[C@H]2C)cc2nc(N[C@@H](CF)c3cccc(Cl)c3)oc12	Homo sapiens	CHEMBL3889250	single protein format
CHEMBL273196	IC50	=	0.03	nM	416.53	CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)CCCN=C(N)N	Homo sapiens	CHEMBL815795	single protein format
CHEMBL143418	IC50	=	0.042	nM	443.46	Cc1nc(N)ccc1CNC(=O)Cn1c(C)cnc(NCC(F)(F)c2ccccn2)c1=O	Homo sapiens	CHEMBL3134872	single protein format
CHEMBL3084831	IC50	=	0.1	nM	576.72	CCCCOC(=O)C(=O)C(NC(=O)[C@@H]1CC[C@H]2CN(S(=O)(=O)Cc3ccccc3)CC(=O)N21)[C@H]1CC[C@H](N)CC1	Homo sapiens	CHEMBL644679	single protein format
CHEMBL3349684	IC50	=	0.1	nM	448.61	N[C@@H](C(=O)N1CCC[C@H]1C(=O)NC[C@H]1CC[C@H](N)CC1)C(c1ccccc1)c1ccccc1	Homo sapiens	CHEMBL808337	single protein format
CHEMBL4111930	IC50	=	0.1	nM	520.0	COc1cc(C(=O)N2CC(C)(CC(C)O)OC[C@H]2C)cc2nc(NC(CF)c3cccc(Cl)c3)oc12	Homo sapiens	CHEMBL3889250	single protein format
CHEMBL4476621	IC50	=	0.103	nM	356.23	O=C(NNC(=S)Nc1ccc(Cl)c(Cl)c1)c1ccccc1O	Homo sapiens	CHEMBL4383330	single protein format
CHEMBL4108161	IC50	=	0.16	nM	491.95	CCO[C@@H]1CC(CO)N(C(=O)c2cc(OC)c3oc(N[C@H](CF)c4cccc(Cl)c4)nc3c2)C1	Homo sapiens	CHEMBL3889250	single protein format
CHEMBL4109095	IC50	=	0.19	nM	491.95	CCO[C@@H]1CC(CO)N(C(=O)c2cc(OC)c3oc(NC(CF)c4cccc(Cl)c4)nc3c2)C1	Homo sapiens	CHEMBL3889250	single protein format
CHEMBL4107222	IC50	=	0.2	nM	505.97	COc1cc(C(=O)N2CC(C)(CCO)OC[C@H]2C)cc2nc(NC(CF)c3cccc(Cl)c3)oc12	Homo sapiens	CHEMBL3889250	single protein format
CHEMBL3889734	IC50	=	0.3	nM	517.99	COc1cc(C(=O)N2C[C@H](C)OC[C@H]2C2CC(O)C2)cc2nc(NC(CF)c3cccc(Cl)c3)oc12	Homo sapiens	CHEMBL3889250	single protein format
CHEMBL3948815	IC50	=	0.37	nM	517.99	COc1cc(C(=O)N2C[C@H](C)OC[C@@H]2C2CC(O)C2)cc2nc(NC(CF)c3cccc(Cl)c3)oc12	Homo sapiens	CHEMBL3889250	single protein format
CHEMBL4114319	IC50	=	0.38	nM	486.93	COc1cc(C(=O)N2CC3(CC3)NC(=O)C2C)cc2nc(N[C@H](CF)c3cccc(Cl)c3)oc12	Homo sapiens	CHEMBL3889250	single protein format
CHEMBL289389	IC50	=	0.467	nM	476.56	Cc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)N[C@H]1CCCN(C(=N)N)C1O	Homo sapiens	CHEMBL818159	single protein format
CHEMBL3944800	IC50	=	0.47	nM	517.99	COc1cc(C(=O)N2CC(C)OCC2C2CC(O)C2)cc2nc(NC(CF)c3cccc(Cl)c3)oc12	Homo sapiens	CHEMBL3889250	single protein format
CHEMBL41267	IC50	=	0.505	nM	462.53	N=C(N)N1CCC[C@H](NC(=O)Cn2cccc(NS(=O)(=O)Cc3ccccc3)c2=O)C1O	Homo sapiens	CHEMBL815796	single protein format
CHEMBL141424	IC50	=	0.67	nM	506.63	N=C(N)N1CCC[C@@H](C[C@@H](C=O)NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1	Homo sapiens	CHEMBL811069	single protein format
CHEMBL423543	IC50	=	0.7	nM	415.54	CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)N[C@H]1CCCC(C(=N)N)C1O	Homo sapiens	CHEMBL816448	single protein format

Pfam Domain Table

[ Domain: "FMN-binding split barrel" // Thrombin_light_1 ]

[ Domain: "FMN-binding split barrel" // Thrombin_light ]

[ Domain: "FMN-binding split barrel" // Thrombin_light_1,Trypsin ]

[ Domain: "FMN-binding split barrel" // Thrombin_light,Trypsin ]

[ Domain: "FMN-binding split barrel 2" // Thrombin_light_1,Trypsin ]

[ Domain: "FMN-binding split barrel 2" // Trypsin ]

[ Domain: "Kringle-like" // Kringle ]

[ Domain: "GLA-domain" // Gla_like ]

[ Domain: "GLA-domain" // Gla_like,Gla ]