P00558 | PGK1_HUMAN | Phosphoglycerate kinase 1 (PGK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00162 | PGK - Phosphoglycerate kinase | 9~406 |
3D structures mapped by conservation among orthologs
[ Domain: "Phosphoglycerate kinase domain 1" // PGK_N ]
[ Domain: "Phosphoglycerate kinase domain 2" // PGK_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3731422 |  |
IC50 | = | 1.0 | nM | 304.78 | CCNc1nc2cc(Cl)c(C#CCO)cc2nc1NCC | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3730386 |  |
IC50 | = | 5.0 | nM | 318.81 | CCNc1nc2cc(Cl)c(C#CCCO)cc2nc1NCC | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3728435 |  |
IC50 | = | 8.0 | nM | 416.96 | CCNc1nc2cc(C#CCCO)c(Cl)cc2nc1NCCN1CCN(C)CC1 | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL1995927 |  |
IC50 | = | 9.0 | nM | 280.76 | CCNc1nc2cc(Cl)c(OC)cc2nc1NCC | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3732725 |  |
IC50 | = | 12.0 | nM | 274.75 | C#Cc1cc2nc(NCC)c(NCC)nc2cc1Cl | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3731664 |  |
IC50 | = | 15.0 | nM | 338.8 | CCNc1nc2cc(Cl)c(C#N)cc2nc1NCc1cccnc1 | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3731002 |  |
IC50 | = | 16.0 | nM | 430.98 | CCNc1nc2cc(C#CCCO)c(Cl)cc2nc1NCCCN1CCN(C)CC1 | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3729175 |  |
IC50 | = | 19.0 | nM | 314.82 | CCNc1nc2cc(Cl)c(C#CC3CC3)cc2nc1NCC | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3730091 |  |
IC50 | = | 36.0 | nM | 515.11 | CN1CCN(CCNc2nc3cc(Cl)c(C#CCCO)cc3nc2NCCN2CCN(C)CC2)CC1 | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3732027 |  |
IC50 | = | 38.0 | nM | 275.74 | CCNc1nc2cc(Cl)c(C#N)cc2nc1NCC | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3729776 |  |
IC50 | = | 41.0 | nM | 310.18 | CCNc1nc2cc(C#CCCO)c(Cl)cc2nc1Cl | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3731566 |  |
IC50 | = | 42.0 | nM | 332.84 | CCNc1nc2cc(Cl)c(C#CCCCO)cc2nc1NCC | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3732479 |  |
IC50 | = | 54.0 | nM | 327.82 | CCNc1nc2cc(Cl)c(C#CCCC#N)cc2nc1NCC | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3730455 |  |
IC50 | = | 66.0 | nM | 317.78 | CCNc1nc2cc(OC)c(Cl)cc2nc1-c1cnn(C)c1 | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3731179 |  |
IC50 | = | 66.0 | nM | 318.81 | CCNc1nc2cc(Cl)c(C#CCOC)cc2nc1NCC | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3732615 |  |
IC50 | = | 71.0 | nM | 373.89 | CCNc1nc2cc(Cl)c(C#N)cc2nc1NCCN1CCN(C)CC1 | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3732983 |  |
IC50 | = | 75.0 | nM | 303.75 | CCNc1nc2cc(OC)c(Cl)cc2nc1-c1cn[nH]c1 | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3731721 |  |
IC50 | = | 78.0 | nM | 369.88 | CCNc1nc2cc(OC)c(Cl)cc2nc1-c1cc2ccccc2s1 | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3732218 |  |
IC50 | = | 91.0 | nM | 393.88 | CCNc1nc2cc(OC)c(Cl)cc2nc1-c1cnn(Cc2ccccc2)c1 | Homo sapiens | CHEMBL3734162 | single protein format |
| CHEMBL3733318 |  |
IC50 | = | 98.0 | nM | 295.73 | CCNc1nc2cc(Cl)c([N+](=O)[O-])cc2nc1NCC | Homo sapiens | CHEMBL3734162 | single protein format |