P00533 | EGFR_HUMAN | Epidermal growth factor receptor (EGFR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00757 | Furin-like - Furin-like cysteine rich region | 185~338 | |
| PF01030 | Recep_L_domain - Receptor L domain | 57~167 | |
| PF01030 | Recep_L_domain - Receptor L domain | 361~480 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 714~966 | |
| PF14843 | GF_recep_IV - Growth factor receptor domain IV | 505~637 | |
| PF21314 | TM_ErbB1 - Epidermal growth factor receptor transmembrane-juxtamembrane segment | 646~681 |
3D structures mapped by conservation among orthologs
[ Domain: "Leucine-rich repeats" // Recep_L_domain ]
[ Domain: "Leucine-rich repeats" // GF_recep_IV,Recep_L_domain ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
- 1M14
- 1M17
- 1XKK
- 2EB2
- 2EB3
- 2GS2
- 2GS6
- 2GS7
- 2ITN
- 2ITO
- 2ITP
- 2ITQ
- 2ITT
- 2ITU
- 2ITV
- 2ITW
- 2ITX
- 2ITY
- 2ITZ
- 2J5E
- 2J5F
- 2J6M
- 2JIT
- 2JIU
- 2JIV
- 2RF9
- 2RFD
- 2RFE
- 2RGP
- 3BEL
- 3GOP
- 3GT8
- 3IKA
- 3LZB
- 3POZ
- 3UG1
- 3UG2
- 3VJN
- 3VJO
- 3W2O
- 3W2P
- 3W2Q
- 3W2R
- 3W2S
- 3W32
- 3W33
- 4G5J
- 4G5P
- 4HJO
- 4I1Z
- 4I20
- 4I21
- 4I22
- 4I23
- 4I24
- 4JQ7
- 4JQ8
- 4JR3
- 4JRV
- 4LI5
- 4LL0
- 4LQM
- 4LRM
- 4R3P
- 4R3R
- 4R5S
- 4RIW
- 4RIX
- 4RIY
- 4RJ4
- 4RJ5
- 4RJ6
- 4RJ7
- 4RJ8
- 4TKS
- 4WD5
- 4WKQ
- 4WRG
- 4ZAU
- 4ZJV
- 4ZSE
- 5C8K
- 5C8M
- 5C8N
- 5CAL
- 5CAN
- 5CAO
- 5CAP
- 5CAQ
- 5CAS
- 5CAU
- 5CAV
- 5CNN
- 5CNO
- 5CZH
- 5CZI
- 5D41
- 5EDP
- 5EDQ
- 5EDR
- 5EM5
- 5EM6
- 5EM7
- 5EM8
- 5FED
- 5FEE
- 5FEQ
- 5GMP
- 5GNK
- 5GTY
- 5GTZ
- 5HCX
- 5HCY
- 5HCZ
- 5HG5
- 5HG7
- 5HG8
- 5HG9
- 5HIB
- 5HIC
- 5J9Y
- 5J9Z
- 5JEB
- 5U8L
- 5UG8
- 5UG9
- 5UGA
- 5UGB
- 5UGC
- 5UWD
- 5X26
- 5X27
- 5X28
- 5X2A
- 5X2C
- 5X2F
- 5X2K
- 5XDK
- 5XDL
- 5XGM
- 5XGN
- 5Y25
- 5Y9T
- 5YU9
- 5ZTO
- 5ZWJ
- 6D8E
- 6DUK
- 6JZ0
- 6P1D
- 6P1L
- 6P8Q
- 6S89
- 6S8A
- 6S9B
- 6S9C
- 6S9D
[ Domain: "Growth factor receptor domain" // GF_recep_IV ]
[ Domain: "Growth factor receptor domain" // Furin-like_4 ]
[ Domain: "Growth factor receptor domain" // Furin-like ]
[ Domain: "Epidermal growth factor receptor transmembrane-juxtamembrane segment" // TM_ErbB1 ]
[ Domain: "Epidermal growth factor receptor transmembrane-juxtamembrane segment" // KOG1025 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL63786 |  |
IC50 | = | 0.003 | nM | 350.22 | Brc1cccc(Nc2ncnc3cc4ccccc4cc23)c1 | Homo sapiens | CHEMBL683040 | cell-based format |
| CHEMBL35820 |  |
IC50 | = | 0.006 | nM | 388.26 | CCOc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCC | Homo sapiens | CHEMBL677389 | cell-based format |
| CHEMBL53711 |  |
IC50 | = | 0.006 | nM | 344.22 | CN(C)c1cc2c(Nc3cccc(Br)c3)ncnc2cn1 | Homo sapiens | CHEMBL674648 | single protein format |
| CHEMBL66031 |  |
IC50 | = | 0.008 | nM | 340.18 | Brc1cccc(Nc2ncnc3cc4[nH]cnc4cc23)c1 | Homo sapiens | CHEMBL679944 | single protein format |
| CHEMBL5270693 |  |
IC50 | = | 0.008 | nM | 562.67 | COc1cc(N2CCC(N(C)C)CC2)ccc1Nc1ncc(C(=O)Oc2ccccc2)c(-c2c[nH]c3ccccc23)n1 | Homo sapiens | CHEMBL5260455 | single protein format |
| CHEMBL53753 |  |
IC50 | = | 0.008 | nM | 330.19 | CNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1 | Homo sapiens | CHEMBL679944 | single protein format |
| CHEMBL176582 |  |
IC50 | = | 0.01 | nM | 354.21 | Cn1cnc2cc3ncnc(Nc4cccc(Br)c4)c3cc21 | Homo sapiens | CHEMBL683040 | cell-based format |
| CHEMBL174426 |  |
IC50 | = | 0.025 | nM | 354.21 | Cn1cnc2cc3c(Nc4cccc(Br)c4)ncnc3cc21 | Homo sapiens | CHEMBL683040 | cell-based format |
| CHEMBL29197 |  |
IC50 | = | 0.025 | nM | 360.21 | COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC | Homo sapiens | CHEMBL677389 | cell-based format |
| CHEMBL5288888 |  |
IC50 | = | 0.027 | nM | 512.97 | C=CC(=O)N1CCC(Oc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2O[C@H]2CCOC2)CC1 | Homo sapiens | CHEMBL5255138 | single protein format |
| CHEMBL1243316 |  |
IC50 | = | 0.03 | nM | 477.93 | C#CCNC/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)c(C#N)cnc2cc1OCC | Homo sapiens | CHEMBL1249168 | single protein format |
| CHEMBL3613702 |  |
IC50 | = | 0.037 | nM | 377.21 | C=CC(=O)Nc1ccc2ncnc(Nc3cc(F)c(Cl)c(Cl)c3)c2c1 | Homo sapiens | CHEMBL3616083 | single protein format |
| CHEMBL363815 |  |
IC50 | = | 0.037 | nM | 377.21 | C=CC(=O)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1 | Homo sapiens | CHEMBL832761 | cell-based format |
| CHEMBL5271803 |  |
IC50 | = | 0.05 | nM | 581.05 | CN(C)CCn1cccc1/C=N/NC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 | Homo sapiens | CHEMBL5230885 | single protein format |
| CHEMBL5284924 |  |
IC50 | = | 0.053 | nM | 548.65 | COc1cc(N2CCN(C)CC2)ccc1Nc1ncc(C(=O)Oc2ccccc2)c(-c2cn(C)c3ccccc23)n1 | Homo sapiens | CHEMBL5260455 | single protein format |
| CHEMBL5282641 |  |
IC50 | = | 0.053 | nM | 547.41 | C=CC(=O)N1CCC(Oc2cc3c(Nc4ccc(Cl)c(Cl)c4F)ncnc3cc2O[C@H]2CCOC2)CC1 | Homo sapiens | CHEMBL5255138 | single protein format |
| CHEMBL275762 |  |
IC50 | = | 0.07 | nM | 399.64 | O=C(CCl)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1 | Homo sapiens | CHEMBL832761 | cell-based format |
| CHEMBL327307 |  |
IC50 | = | 0.072 | nM | 439.11 | COc1cc2ncnc(Nc3ccc(Br)c(Br)c3)c2cc1OC | Homo sapiens | CHEMBL680017 | cell-based format |
| CHEMBL180022 |  |
IC50 | = | 0.08 | nM | 557.05 | CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C | Homo sapiens | CHEMBL892951 | single protein format |
| CHEMBL53428 |  |
IC50 | = | 0.09 | nM | 344.22 | CN(C)c1cc2ncnc(Nc3cccc(Br)c3)c2cn1 | Homo sapiens | CHEMBL677387 | single protein format |