P00519 | ABL1_HUMAN | Tyrosine-protein kinase ABL1 (ABL1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 127~202 | |
| PF00018 | SH3_1 - SH3 domain | 67~113 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 242~492 | |
| PF08919 | F_actin_bind - F-actin binding | 1026~1130 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // SH3_1 ]
[ Domain: "F-actin binding domain of Abl" // F_actin_bind ]
[ Domain: "SH2" // SH2 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2347725 |  |
IC50 | = | 0.015 | nM | 425.56 | COc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCN(C)CC3)sc2c1 | Homo sapiens | CHEMBL2353816 | assay format |
| CHEMBL2347722 |  |
IC50 | = | 0.021 | nM | 412.52 | COc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCOCC3)sc2c1 | Homo sapiens | CHEMBL2353816 | assay format |
| CHEMBL2347711 |  |
IC50 | = | 0.064 | nM | 341.44 | CCNC(=O)Nc1nc2ccc(-c3ccccc3OCC)cc2s1 | Homo sapiens | CHEMBL2353816 | assay format |
| CHEMBL2347723 |  |
IC50 | = | 0.064 | nM | 343.41 | COc1ccccc1-c1ccc2nc(NC(=O)NCCO)sc2c1 | Homo sapiens | CHEMBL2353816 | assay format |
| CHEMBL3929380 |  |
IC50 | < | 0.1 | nM | 501.88 | N#Cc1cncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2C[C@H](O)[C@@H](O)C2)c1 | Homo sapiens | CHEMBL3888132 | single protein format |
| CHEMBL3909373 |  |
IC50 | < | 0.1 | nM | 473.41 | N#Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2C[C@H](O)[C@@H](O)C2)[nH]1 | Homo sapiens | CHEMBL3888453 | single protein format |
| CHEMBL2347710 |  |
IC50 | = | 0.11 | nM | 327.41 | CCNC(=O)Nc1nc2ccc(-c3ccccc3OC)cc2s1 | Homo sapiens | CHEMBL2353816 | assay format |
| CHEMBL2347719 |  |
IC50 | = | 0.11 | nM | 342.42 | CCNC(=O)Nc1nc2ccc(-c3ccc(N)cc3OC)cc2s1 | Homo sapiens | CHEMBL2353816 | assay format |
| CHEMBL2347729 |  |
IC50 | = | 0.12 | nM | 425.56 | CCOc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCNCC3)sc2c1 | Homo sapiens | CHEMBL2353816 | assay format |
| CHEMBL2347728 |  |
IC50 | = | 0.13 | nM | 371.46 | CCOc1ccccc1-c1ccc2nc(NC(=O)NCCCO)sc2c1 | Homo sapiens | CHEMBL2353816 | assay format |
| CHEMBL2347724 |  |
IC50 | = | 0.16 | nM | 357.44 | COc1ccccc1-c1ccc2nc(NC(=O)NCCCO)sc2c1 | Homo sapiens | CHEMBL2353816 | assay format |
| CHEMBL2316583 |  |
IC50 | = | 0.17 | nM | 518.54 | CN1CCN(Cc2ccc(NC(=O)c3cccc(C#Cc4cnc5[nH]ncc5c4)c3)cc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL2320765 | cell-based format |
| CHEMBL2347727 |  |
IC50 | = | 0.18 | nM | 357.44 | CCOc1ccccc1-c1ccc2nc(NC(=O)NCCO)sc2c1 | Homo sapiens | CHEMBL2353816 | assay format |
| CHEMBL4112072 |  |
IC50 | = | 0.2 | nM | 474.9 | Cc1ccncc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cnc1N1CC[C@@H](O)C1 | Homo sapiens | CHEMBL3888133 | single protein format |
| CHEMBL3967070 |  |
IC50 | = | 0.2 | nM | 433.39 | CC1(O)CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ncc[nH]2)C1 | Homo sapiens | CHEMBL3888453 | single protein format |
| CHEMBL3939040 |  |
IC50 | = | 0.2 | nM | 459.43 | O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@H](CO)C2)c(-c2cncnc2)c1 | Homo sapiens | CHEMBL3888133 | single protein format |
| CHEMBL4109082 |  |
IC50 | = | 0.2 | nM | 512.41 | N[C@]1(C(F)(F)F)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 | Homo sapiens | CHEMBL3888132 | single protein format |
| CHEMBL4107478 |  |
IC50 | = | 0.2 | nM | 444.41 | O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccccn2)c1 | Homo sapiens | CHEMBL3888132 | single protein format |
| CHEMBL2347726 |  |
IC50 | = | 0.23 | nM | 426.54 | CCOc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCOCC3)sc2c1 | Homo sapiens | CHEMBL2353816 | assay format |
| CHEMBL4108934 |  |
IC50 | = | 0.3 | nM | 478.86 | O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cccnc2F)c1 | Homo sapiens | CHEMBL3888133 | single protein format |