P00403 | COX2_HUMAN | Cytochrome c oxidase subunit 2 (MT-CO2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00116 | COX2 - Cytochrome C oxidase subunit II, periplasmic domain | 95~213 | |
| PF02790 | COX2_TM - Cytochrome C oxidase subunit II, transmembrane domain | 4~83 |
3D structures mapped by conservation among orthologs
[ Domain: "Cupredoxin-related" // COX2 ]
[ Domain: "Cytochrome c oxidase subunit II-like, transmembrane region" // COX2_TM ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL122 |  |
IC50 | = | 20.0 | nM | 314.36 | CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 | Homo sapiens | CHEMBL4363182 | single protein format |
| CHEMBL254418 |  |
IC50 | = | 40.0 | nM | 348.38 | Cc1onc(-c2ccccc2)c1-c1ccc(S(=O)(=O)NO)cc1.O | Homo sapiens | CHEMBL967597 | single protein format |
| CHEMBL5199117 |  |
IC50 | = | 190.0 | nM | 382.85 | Cc1c(Cl)cccc1Nc1ccccc1C(=O)NCc1ccc(O)c(O)c1 | Homo sapiens | CHEMBL5141433 | single protein format |
| CHEMBL5207189 |  |
IC50 | = | 240.0 | nM | 400.84 | Cc1c(Cl)cccc1Nc1ccc(F)cc1C(=O)NCc1ccc(O)c(O)c1 | Homo sapiens | CHEMBL5141433 | single protein format |
| CHEMBL4448990 |  |
IC50 | = | 367.0 | nM | 263.72 | CC(=O)N(C1=CC(=O)CCC1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4363122 | single protein format |
| CHEMBL441414 |  |
IC50 | = | 390.0 | nM | 248.32 | C[C@H](C(=O)O)c1ccc(C[C@H]2CCC[C@@H]2O)cc1 | Homo sapiens | CHEMBL5162741 | single protein format |
| CHEMBL5193981 |  |
IC50 | = | 490.0 | nM | 366.85 | Cc1c(Cl)cccc1Nc1ccccc1C(=O)NCc1ccc(O)cc1 | Homo sapiens | CHEMBL5141433 | single protein format |
| CHEMBL4441570 |  |
IC50 | = | 513.0 | nM | 221.69 | O=C1C=C(Nc2ccc(Cl)cc2)CCC1 | Homo sapiens | CHEMBL4363122 | single protein format |
| CHEMBL118 |  |
IC50 | = | 540.0 | nM | 381.38 | Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 | Homo sapiens | CHEMBL4133558 | single protein format |
| CHEMBL5173923 |  |
IC50 | = | 550.0 | nM | 352.82 | O=C(NCc1ccc(O)cc1)c1ccccc1Nc1cccc(Cl)c1 | Homo sapiens | CHEMBL5141433 | single protein format |
| CHEMBL5191029 |  |
IC50 | = | 560.0 | nM | 384.84 | Cc1c(Cl)cccc1Nc1ccccc1C(=O)NCc1ccc(O)c(F)c1 | Homo sapiens | CHEMBL5141433 | single protein format |
| CHEMBL6 |  |
IC50 | = | 610.0 | nM | 357.79 | COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4133558 | single protein format |
| CHEMBL4474644 |  |
IC50 | = | 915.0 | nM | 321.8 | CC(C)(C)OC(=O)N(C1=CC(=O)CCC1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4363122 | single protein format |
| CHEMBL5170447 |  |
IC50 | = | 930.0 | nM | 402.83 | Cc1c(Cl)cccc1Nc1ccc(F)cc1C(=O)NCc1ccc(O)c(F)c1 | Homo sapiens | CHEMBL5141433 | single protein format |
| CHEMBL4754218 |  |
IC50 | = | 980.0 | nM | 386.43 | Cc1ccc(C(=O)CC2CC(=O)N(c3ccc(S(N)(=O)=O)cc3)C2=O)cc1 | Homo sapiens | CHEMBL4722423 | cell-based format |